PMID- 30837053
OWN - NLM
STAT- MEDLINE
DCOM- 20190514
LR  - 20190514
IS  - 1000-503X (Print)
IS  - 1000-503X (Linking)
VI  - 41
IP  - 1
DP  - 2019 Feb 28
TI  - [Research Advances in Mitogen-activated Protein Kinases in Central and Peripheral 
      Sensitization of Diabetic Neuropathic Pain].
PG  - 118-123
LID - 10.3881/j.issn.1000-503X.10396 [doi]
AB  - Mitogen-activated protein kinases(MAPKs)are Ser/Thr kinases consisting of 
      extracellular regulated protein kinases(ERK)1/2,c-Jun N-terminal kinase 1/2/3,p38 
      isoforms(alpha,beta,gamma,and delta),and ERK5,which mediate a range of cellular activities 
      including proliferation,differentiation,apoptosis,immunity,and inflammation. Pain 
      sensitization is a remodeling mechanism of central and peripheral nociceptor. A 
      growing number of evidences have indicated that MAPKs are extensively activated 
      in the spinal dorsal cord and dorsal root ganglions in the animal models of 
      diabetic neuropathic pain(DNP)and play an important role in the central and 
      peripheral sensitization of DNP. In addition,some drugs can alleviate DNP by 
      suppressing MAPKs activation of central and peripheral nervous system. This 
      article summarizes the research progress of MAPKs in central and peripheral 
      sensitization of DNP.
FAU - Zhang, Xin
AU  - Zhang X
AD  - Department of Anesthesiology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
FAU - Shen, Le
AU  - Shen L
AD  - Department of Anesthesiology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
FAU - Huang, Yu Guang
AU  - Huang YG
AD  - Department of Anesthesiology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhongguo Yi Xue Ke Xue Yuan Xue Bao
JT  - Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae
JID - 8006230
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
RN  - EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases)
SB  - IM
MH  - Animals
MH  - *Diabetic Neuropathies
MH  - Ganglia, Spinal
MH  - Mitogen-Activated Protein Kinases
MH  - *Neuralgia
MH  - p38 Mitogen-Activated Protein Kinases
EDAT- 2019/03/07 06:00
MHDA- 2019/05/15 06:00
CRDT- 2019/03/07 06:00
PHST- 2019/03/07 06:00 [entrez]
PHST- 2019/03/07 06:00 [pubmed]
PHST- 2019/05/15 06:00 [medline]
AID - 10.3881/j.issn.1000-503X.10396 [doi]
PST - ppublish
SO  - Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2019 Feb 28;41(1):118-123. doi: 
      10.3881/j.issn.1000-503X.10396.