PMID- 30837427
OWN - NLM
STAT- MEDLINE
DCOM- 20190422
LR  - 20221207
IS  - 1119-3077 (Print)
VI  - 22
IP  - 3
DP  - 2019 Mar
TI  - The relationship between plasma homocysteine levels and MTHFR gene variation, 
      age, and sex in Northeast China.
PG  - 380-385
LID - 10.4103/njcp.njcp_291_18 [doi]
AB  - BACKGROUND: Hyperhomocysteinemia (HHcy) is the risk factor for cardiovascular 
      disease and stroke. However, the impacts on the genetic variation of methylene 
      tetrahydrofolate reductase (MTHFR) on plasma homocysteine levels in the Northeast 
      Chinese population have not been studied. Therefore, this study was carried out 
      to determine the relationship between HHcy and MTHFR gene variation, and whether 
      it was influenced by age and sex of the population in Northeast China. MATERIALS 
      AND METHODS: A total of 466 subjects were randomly enrolled in this study. 
      According to the homocysteine levels (Hcy >/= 15 mumol/L) of the subjects, they were 
      divided into hyperhomocysteine (HHcy = 206) and normal homocysteine (Hcy = 260). 
      Polymerase chain reaction/high-resolution dissolution curve and homocysteine 
      determination kit methods were used for genotype testing and homocysteine 
      detection, respectively. RESULTS: High plasma homocysteine levels are associated 
      with MTHFR 677T and 1298A [P < 0.00, odds ratio (confidence interval) = 1.842 
      (1.418-2.394) >1], which is related to increasing age (P(range) = 0.0005-0.0161), 
      with the homocysteine levels of males higher than females (P < 0.0001). 
      CONCLUSION: High plasma homocysteine levels were linked to the MTHFR gene 
      mutation. In addition, plasma homocysteine levels increased significantly with 
      age with male's homocysteine levels higher than that of females.
FAU - Wang, F
AU  - Wang F
AD  - Department of Geriatric Medicine, The First Affiliated Hospital of Jiamusi 
      University, Heilongjiang, People's Republic of China.
FAU - Sui, X
AU  - Sui X
AD  - Department of Geriatric Medicine, The First Affiliated Hospital of Jiamusi 
      University, Heilongjiang, People's Republic of China.
FAU - Xu, N
AU  - Xu N
AD  - Department of Geriatric Medicine, The First Affiliated Hospital of Jiamusi 
      University, Heilongjiang; Chinese Ministry of Health Key Laboratory of 
      Geriatrics, Beijing Hospital, National Center of Gerontology, Beijing, People's 
      Republic of China.
FAU - Yang, J
AU  - Yang J
AD  - Department of Geriatric Medicine, The First Affiliated Hospital of Jiamusi 
      University, Heilongjiang, People's Republic of China.
FAU - Zhao, H
AU  - Zhao H
AD  - Department of Geriatric Medicine, The First Affiliated Hospital of Jiamusi 
      University, Heilongjiang, People's Republic of China.
FAU - Fei, X
AU  - Fei X
AD  - Department of Geriatric Medicine, The First Affiliated Hospital of Jiamusi 
      University, Heilongjiang, People's Republic of China.
FAU - Zhang, Z
AU  - Zhang Z
AD  - Department of Geriatric Medicine, The First Affiliated Hospital of Jiamusi 
      University, Heilongjiang, People's Republic of China.
FAU - Luo, Z
AU  - Luo Z
AD  - Department of Geriatric Medicine, The First Affiliated Hospital of Jiamusi 
      University, Heilongjiang, People's Republic of China.
FAU - Xin, Y
AU  - Xin Y
AD  - Department of Geriatric Medicine, The First Affiliated Hospital of Jiamusi 
      University, Heilongjiang, People's Republic of China.
FAU - Qin, B
AU  - Qin B
AD  - Chinese Ministry of Health Key Laboratory of Geriatrics, Beijing Hospital, 
      National Center of Gerontology, Beijing, People's Republic of China.
FAU - Zhao, X
AU  - Zhao X
AD  - Chinese Ministry of Health Key Laboratory of Geriatrics, Beijing Hospital, 
      National Center of Gerontology, Beijing, People's Republic of China.
FAU - Cao, S
AU  - Cao S
AD  - Chinese Ministry of Health Key Laboratory of Geriatrics, Beijing Hospital, 
      National Center of Gerontology, Beijing, People's Republic of China.
FAU - Zhang, Y
AU  - Zhang Y
AD  - Chinese Ministry of Health Key Laboratory of Geriatrics, Beijing Hospital, 
      National Center of Gerontology, Beijing, People's Republic of China.
FAU - Yang, Z
AU  - Yang Z
AD  - Chinese Ministry of Health Key Laboratory of Geriatrics, Beijing Hospital, 
      National Center of Gerontology, Beijing, People's Republic of China.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Niger J Clin Pract
JT  - Nigerian journal of clinical practice
JID - 101150032
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - EC 1.5.1.20 (MTHFR protein, human)
RN  - EC 1.5.1.20 (Methylenetetrahydrofolate Reductase (NADPH2))
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Asian People/*genetics
MH  - Cardiovascular Diseases/etiology
MH  - China
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Homocysteine/*blood
MH  - Humans
MH  - Hyperhomocysteinemia/complications/*genetics
MH  - Male
MH  - Methylenetetrahydrofolate Reductase (NADPH2)/*genetics
MH  - Middle Aged
MH  - Odds Ratio
MH  - Polymerase Chain Reaction
MH  - *Polymorphism, Genetic
MH  - Risk Factors
MH  - Sex Factors
MH  - Stroke/etiology
OTO - NOTNLM
OT  - Age
OT  - MTHFR gene
OT  - Northeast China
OT  - gender
OT  - homocysteine
COIS- None
EDAT- 2019/03/07 06:00
MHDA- 2019/04/23 06:00
CRDT- 2019/03/07 06:00
PHST- 2019/03/07 06:00 [entrez]
PHST- 2019/03/07 06:00 [pubmed]
PHST- 2019/04/23 06:00 [medline]
AID - NigerJClinPract_2019_22_3_380_253447 [pii]
AID - 10.4103/njcp.njcp_291_18 [doi]
PST - ppublish
SO  - Niger J Clin Pract. 2019 Mar;22(3):380-385. doi: 10.4103/njcp.njcp_291_18.