PMID- 30837491
OWN - NLM
STAT- MEDLINE
DCOM- 20200921
LR  - 20200921
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 9
IP  - 1
DP  - 2019 Mar 5
TI  - Neural correlates of early adversity among Bangladeshi infants.
PG  - 3507
LID - 10.1038/s41598-019-39242-x [doi]
LID - 3507
AB  - In this paper we explore the relationship between the Visual Evoked Potential 
      (VEP), a component of the electroencephalogram elicited by visual stimuli, and 
      cognitive functions in children growing up in an urban slum in Bangladesh. VEPs 
      in response to pattern-reversing checkerboards were collected in 6 
      month-old-infants (n = 91) and 36-month-old children (n = 112). We examine 
      variation in the amplitude and latency of the first positive component, the P1, 
      of the VEP in relation to cognitive scores on the Mullen Scales of Early Learning 
      and the Wechsler Preschool and Primary Scale of Intelligence. We also examine 
      whether children's caregiving experiences prior to the neuro-cognitive assessment 
      explain variation in the P1 of the VEP. We find that the P1 amplitude of the VEP 
      is related to concurrent cognitive performance in each respective cohort. We also 
      find that the P1 amplitude at 6 months is prospectively associated with cognitive 
      outcomes at 27 months, and the P1 amplitude at 36 months is prospectively 
      associated with children's IQ at 60 months. We find no associations between 
      caregiving experiences and variation in the P1 of the VEP at 6 months, yet 
      caregiving experience do explain variation in the P1 amplitude at 36 months. 
      Caregiving experiences also explain variation in children's concurrent and 
      prospective cognitive functioning. The VEP may be used as a biomarker to index 
      the neurobiological embedding of early adversity, which in turn may impact 
      children's cognitive functions.
FAU - Jensen, Sarah K G
AU  - Jensen SKG
AD  - Boston Children's Hospital, Boston, Massachusetts, USA. sarahkgeorg@gmail.com.
AD  - Harvard Medical School, Boston, Massachusetts, USA. sarahkgeorg@gmail.com.
FAU - Kumar, Swapna
AU  - Kumar S
AD  - Boston Children's Hospital, Boston, Massachusetts, USA.
FAU - Xie, Wanze
AU  - Xie W
AD  - Boston Children's Hospital, Boston, Massachusetts, USA.
AD  - Harvard Medical School, Boston, Massachusetts, USA.
FAU - Tofail, Fahmida
AU  - Tofail F
AD  - ICDDR, B, Dhaka, Bangladesh.
FAU - Haque, Rashidul
AU  - Haque R
AD  - ICDDR, B, Dhaka, Bangladesh.
FAU - Petri, William A
AU  - Petri WA
AD  - University of Virginia, Infectious Diseases & International Health, 
      Charlottesville, Virginia, USA.
FAU - Nelson, Charles A
AU  - Nelson CA
AD  - Boston Children's Hospital, Boston, Massachusetts, USA.
AD  - Harvard Medical School, Boston, Massachusetts, USA.
AD  - Harvard Graduate School of Education, Cambridge, Massachusetts, USA.
LA  - eng
GR  - R01 AI043596/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20190305
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
SB  - IM
MH  - Bangladesh
MH  - Child, Preschool
MH  - Cognition/*physiology
MH  - Cohort Studies
MH  - Electroencephalography
MH  - Evoked Potentials, Visual
MH  - Female
MH  - Humans
MH  - Infant
MH  - Infant Care
MH  - Intelligence Tests
MH  - Male
MH  - Neurons/*physiology
MH  - Social Class
PMC - PMC6401115
COIS- The authors declare no competing interests.
EDAT- 2019/03/07 06:00
MHDA- 2020/09/22 06:00
PMCR- 2019/03/05
CRDT- 2019/03/07 06:00
PHST- 2018/04/13 00:00 [received]
PHST- 2019/01/16 00:00 [accepted]
PHST- 2019/03/07 06:00 [entrez]
PHST- 2019/03/07 06:00 [pubmed]
PHST- 2020/09/22 06:00 [medline]
PHST- 2019/03/05 00:00 [pmc-release]
AID - 10.1038/s41598-019-39242-x [pii]
AID - 39242 [pii]
AID - 10.1038/s41598-019-39242-x [doi]
PST - epublish
SO  - Sci Rep. 2019 Mar 5;9(1):3507. doi: 10.1038/s41598-019-39242-x.