PMID- 30837641
OWN - NLM
STAT- MEDLINE
DCOM- 20200922
LR  - 20200922
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 9
IP  - 1
DP  - 2019 Mar 5
TI  - Carbon nanoparticles with oligonucleotide probes for a label-free sensitive 
      antibiotic residues detection based on competitive analysis.
PG  - 3489
LID - 10.1038/s41598-019-40209-1 [doi]
LID - 3489
AB  - Carbon nanoparticles (CNPs) have been combined with aptamer, providing a broad 
      application in small molecule. CNPs can be quenched by small molecules and are 
      usually applied as luminescent probes because of their photophysical 
      characteristics. In this work, we developed a competitive analysis for antibiotic 
      residues detection based on carbon nanoparticles (CNPs) and oligonucleotide 
      probes. Oligonucleotide probes including oxytetracycline (OTC) aptamer was 
      exploited for recognition OTC and was used to restore the luminescence. 
      Tetracycline (TC), as a competitor of OTC, was utilized to quench the 
      luminescence of CNPs and reduce the sample matrix effect. Under optimal 
      conditions, the linear rang of OTC was 0.010~1.0 ng/mL with the relative standard 
      deviations (RSDs) from 2.91% to 11.3%, and the limit of detection (LOD) was low 
      to 0.002 ng/mL. Moreover, the proposal was successfully applied to analyze OTC 
      from drink water, indicating that this approach has great potential for other 
      small molecule analysis.
FAU - Lin, Xuexia
AU  - Lin X
AUID- ORCID: 0000-0002-4761-6844
AD  - Depaertment of Chemical Engineering & Pharmaceutical Engineering, College of 
      Chemical Engineering, Huaqiao University, Xiamen, 361021, China. 
      linxuexia@hqu.edu.cn.
FAU - Su, Jianlong
AU  - Su J
AD  - Depaertment of Chemical Engineering & Pharmaceutical Engineering, College of 
      Chemical Engineering, Huaqiao University, Xiamen, 361021, China.
FAU - Lin, Honggui
AU  - Lin H
AD  - School of Marine Engineering, Jimei University, Xiamen, 361021, China.
FAU - Zhou, Shu-Feng
AU  - Zhou SF
AD  - Depaertment of Chemical Engineering & Pharmaceutical Engineering, College of 
      Chemical Engineering, Huaqiao University, Xiamen, 361021, China.
FAU - Sun, Xiangying
AU  - Sun X
AD  - College of Materials Science and Engineering, Huaqiao University, Xiamen, 361021, 
      China.
FAU - Liu, Bin
AU  - Liu B
AD  - College of Materials Science and Engineering, Huaqiao University, Xiamen, 361021, 
      China.
FAU - Zeng, Mingrong
AU  - Zeng M
AD  - Depaertment of Chemical Engineering & Pharmaceutical Engineering, College of 
      Chemical Engineering, Huaqiao University, Xiamen, 361021, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190305
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Aptamers, Nucleotide)
RN  - 0 (DNA, Single-Stranded)
RN  - 0 (Oligonucleotide Probes)
RN  - 7440-44-0 (Carbon)
RN  - F8VB5M810T (Tetracycline)
RN  - X20I9EN955 (Oxytetracycline)
SB  - IM
MH  - Anti-Bacterial Agents/*analysis
MH  - Aptamers, Nucleotide/chemistry
MH  - Carbon/*chemistry
MH  - DNA, Single-Stranded/chemistry
MH  - Fresh Water/analysis
MH  - Hydrogen-Ion Concentration
MH  - Limit of Detection
MH  - Nanoparticles/*chemistry
MH  - Oligonucleotide Probes/*chemistry
MH  - Oxytetracycline/analysis
MH  - Tetracycline/analysis
PMC - PMC6401375
COIS- The authors declare no competing interests.
EDAT- 2019/03/07 06:00
MHDA- 2020/09/23 06:00
PMCR- 2019/03/05
CRDT- 2019/03/07 06:00
PHST- 2018/08/08 00:00 [received]
PHST- 2019/02/12 00:00 [accepted]
PHST- 2019/03/07 06:00 [entrez]
PHST- 2019/03/07 06:00 [pubmed]
PHST- 2020/09/23 06:00 [medline]
PHST- 2019/03/05 00:00 [pmc-release]
AID - 10.1038/s41598-019-40209-1 [pii]
AID - 40209 [pii]
AID - 10.1038/s41598-019-40209-1 [doi]
PST - epublish
SO  - Sci Rep. 2019 Mar 5;9(1):3489. doi: 10.1038/s41598-019-40209-1.