PMID- 30839206
OWN - NLM
STAT- MEDLINE
DCOM- 20190708
LR  - 20191210
IS  - 1520-5118 (Electronic)
IS  - 0021-8561 (Linking)
VI  - 67
IP  - 17
DP  - 2019 May 1
TI  - Simultaneous Determination of Acrylamide and 5-Hydroxymethylfurfural in 
      Heat-Processed Foods Employing Enhanced Matrix Removal-Lipid as a New Dispersive 
      Solid-Phase Extraction Sorbent Followed by Liquid Chromatography-Tandem Mass 
      Spectrometry.
PG  - 5017-5025
LID - 10.1021/acs.jafc.8b05703 [doi]
AB  - The goal of this study was to develop a method for simultaneous determination of 
      acrylamide (AA) and 5-hydroxymethylfurfural (5-HMF) in heat-processed foods by 
      liquid chromatography-tandem mass spectrometry analysis. Several cleanup methods 
      for the quick, easy, cheap, effective, rugged, and safe (QuEChERS) protocol were 
      investigated and compared: (a) dispersive solid-phase extraction (d-SPE) with 
      Enhanced Matrix Removal-Lipid (EMR-Lipid), (b) d-SPE with primary secondary 
      amine, (c) without the cleanup step, and (d) cleanup with n-hexane. It is the 
      first time that EMR-Lipid sorbent has been used as a d-SPE material to detect AA 
      and 5-HMF in heat-processed foods, and among the four cleanup methods, the 
      EMR-Lipid method provided the best cleanup of co-extracted matrix interferences 
      and the highest extraction efficiency. Validation experiments were carried out 
      for the method using EMR-Lipid as the d-SPE sorbent. Excellent linearity ( R(2) > 
      0.999) was achieved, and the limits of detection (LODs) of AA and 5-HMF were 2.5 
      and 12.5 mug/kg, respectively. The recoveries of AA and 5-HMF levels obtained were 
      in the ranges of 87.3-103.3 and 83.2-104.3%, with precision [relative standard 
      deviations (RSDs)] of 1.2-6.8 and 1.4-7.4% ( n = 3), respectively. The method is 
      accurate and reliable and was successfully applied to analyze the AA and 5-HMF in 
      eight categories of Chinese heat-processed foods.
FAU - Huang, Yousheng
AU  - Huang Y
AD  - State Key Laboratory of Food Science and Technology, China-Canada Joint 
      Laboratory of Food Science and Technology (Nanchang) , Nanchang University , 235 
      Nanjing East Road , Nanchang , Jiangxi 330047 , People's Republic of China.
AD  - Jiangxi Institute of Analysis and Testing , Nanchang , Jiangxi 330029 , People's 
      Republic of China.
FAU - Li, Chang
AU  - Li C
AD  - State Key Laboratory of Food Science and Technology, China-Canada Joint 
      Laboratory of Food Science and Technology (Nanchang) , Nanchang University , 235 
      Nanjing East Road , Nanchang , Jiangxi 330047 , People's Republic of China.
FAU - Hu, Huiyu
AU  - Hu H
AD  - State Key Laboratory of Food Science and Technology, China-Canada Joint 
      Laboratory of Food Science and Technology (Nanchang) , Nanchang University , 235 
      Nanjing East Road , Nanchang , Jiangxi 330047 , People's Republic of China.
FAU - Wang, Yuting
AU  - Wang Y
AD  - State Key Laboratory of Food Science and Technology, China-Canada Joint 
      Laboratory of Food Science and Technology (Nanchang) , Nanchang University , 235 
      Nanjing East Road , Nanchang , Jiangxi 330047 , People's Republic of China.
FAU - Shen, Mingyue
AU  - Shen M
AD  - State Key Laboratory of Food Science and Technology, China-Canada Joint 
      Laboratory of Food Science and Technology (Nanchang) , Nanchang University , 235 
      Nanjing East Road , Nanchang , Jiangxi 330047 , People's Republic of China.
FAU - Nie, Shaoping
AU  - Nie S
AUID- ORCID: 0000-0002-2412-4679
AD  - State Key Laboratory of Food Science and Technology, China-Canada Joint 
      Laboratory of Food Science and Technology (Nanchang) , Nanchang University , 235 
      Nanjing East Road , Nanchang , Jiangxi 330047 , People's Republic of China.
FAU - Chen, Jie
AU  - Chen J
AD  - State Key Laboratory of Food Science and Technology , Jiangnan University , Wuxi 
      , Jiangsu 214122 , People's Republic of China.
FAU - Zeng, Maomao
AU  - Zeng M
AUID- ORCID: 0000-0001-9259-1992
AD  - State Key Laboratory of Food Science and Technology , Jiangnan University , Wuxi 
      , Jiangsu 214122 , People's Republic of China.
FAU - Xie, Mingyong
AU  - Xie M
AUID- ORCID: 0000-0003-3004-7638
AD  - State Key Laboratory of Food Science and Technology, China-Canada Joint 
      Laboratory of Food Science and Technology (Nanchang) , Nanchang University , 235 
      Nanjing East Road , Nanchang , Jiangxi 330047 , People's Republic of China.
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20190318
PL  - United States
TA  - J Agric Food Chem
JT  - Journal of agricultural and food chemistry
JID - 0374755
RN  - 0 (Lipids)
RN  - 20R035KLCI (Acrylamide)
RN  - 70ETD81LF0 (5-hydroxymethylfurfural)
RN  - DJ1HGI319P (Furaldehyde)
SB  - IM
MH  - Acrylamide/*analysis/*isolation & purification
MH  - Chromatography, Liquid/methods
MH  - Cooking
MH  - Food Contamination/analysis
MH  - Furaldehyde/*analogs & derivatives/analysis/isolation & purification
MH  - Hot Temperature
MH  - Limit of Detection
MH  - Lipids/chemistry
MH  - Solid Phase Extraction/instrumentation/*methods
MH  - Tandem Mass Spectrometry/methods
OTO - NOTNLM
OT  - 5-hydroxymethylfurfural
OT  - EMR-Lipid
OT  - LC-MS/MS
OT  - QuEChERS
OT  - acrylamide
OT  - heat-processed foods
EDAT- 2019/03/07 06:00
MHDA- 2019/07/10 06:00
CRDT- 2019/03/07 06:00
PHST- 2019/03/07 06:00 [pubmed]
PHST- 2019/07/10 06:00 [medline]
PHST- 2019/03/07 06:00 [entrez]
AID - 10.1021/acs.jafc.8b05703 [doi]
PST - ppublish
SO  - J Agric Food Chem. 2019 May 1;67(17):5017-5025. doi: 10.1021/acs.jafc.8b05703. 
      Epub 2019 Mar 18.