PMID- 30840547
OWN - NLM
STAT- MEDLINE
DCOM- 20191209
LR  - 20191217
IS  - 0969-0700 (Print)
IS  - 0969-0700 (Linking)
VI  - 28
IP  - 3
DP  - 2019 Mar 3
TI  - Topical application of haemoglobin: a safety study.
PG  - 148-153
LID - 10.12968/jowc.2019.28.3.148 [doi]
AB  - OBJECTIVE: Ischaemia is one of the biggest problems in wound healing. It causes 
      chronic wounds and also prevents normal wound healing because the tissue is 
      oxygen deprived. Most oxygen-supplying therapies are only feasible in a clinical 
      setting, but topical haemoglobin applications, such as Granulox, can be used in a 
      non-clinical setting. For home application, the haemoglobin solution is sprayed 
      topically onto the wound using a pressurised ready-to-use device with a 
      bag-on-valve system. Although this system does not mix product and propellant, 
      the risk of product inhalation by the patient, user or bystanders has to be 
      minimised. This safety study aimed to determine particle size and product 
      concentration in the surroundings after application to determine if there is a 
      risk that product particles enter the respiratory tract. METHODS: Measurements 
      were performed using a laser scattered light photometer and a Scanning Mobility 
      Particle Sizer (SMPS)-Spectrometer at different distances from the measuring 
      devices to determine the inhalation risk for a possible user, patient and 
      bystander. At all measuring points the amount of particles, their size and the 
      formation of dust were measured. RESULTS: No nanoparticles or dust were created 
      during the application of the haemoglobin spray. The concentrations of the 
      measured particles are below the allowed limits defined by Austrian law. 
      CONCLUSION: There is no risk of inhaling nanoparticles or being exposed to 
      harmful concentrations of larger particles of the tested product. All the 
      product's ingredients can be degraded and excreted by the human body through 
      natural pathways.
FAU - Holzer, Judith Cj
AU  - Holzer JC
AD  - Division of Plastic, Aesthetic and Reconstructive Surgery, Department of Surgery, 
      Medical University of Graz, Graz, Austria.
AD  - COREMED - Cooperative Centre for Regenerative Medicine, Joanneum Research 
      Forschungsgesellschaft mbH, Graz, Austria.
FAU - Birngruber, Thomas
AU  - Birngruber T
AD  - HEALTH - Institute for Biomedicine and Health Sciences, Joanneum Research 
      Forschungsgesellschaft mbH, Graz, Austria.
FAU - Mautner, Selma
AU  - Mautner S
AD  - Division of Plastic, Aesthetic and Reconstructive Surgery, Department of Surgery, 
      Medical University of Graz, Graz, Austria.
AD  - HEALTH - Institute for Biomedicine and Health Sciences, Joanneum Research 
      Forschungsgesellschaft mbH, Graz, Austria.
FAU - Graff, Alexander
AU  - Graff A
AD  - Technical Department, Austrian Dust-Silicosis Control Center (OSBS), Leoben, 
      Austria.
FAU - Kamolz, Lars-Peter
AU  - Kamolz LP
AD  - Division of Plastic, Aesthetic and Reconstructive Surgery, Department of Surgery, 
      Medical University of Graz, Graz, Austria.
AD  - COREMED - Cooperative Centre for Regenerative Medicine, Joanneum Research 
      Forschungsgesellschaft mbH, Graz, Austria.
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Wound Care
JT  - Journal of wound care
JID - 9417080
RN  - 0 (Air Pollutants)
RN  - 0 (Dust)
RN  - 0 (Hemoglobins)
MH  - Administration, Cutaneous
MH  - Air Pollutants
MH  - Dust
MH  - Equipment Design
MH  - Hemoglobins/*administration & dosage/adverse effects
MH  - Humans
MH  - Nanoparticles
MH  - *Occlusive Dressings
MH  - Skin Ulcer/*therapy
OTO - NOTNLM
OT  - chronic wounds
OT  - ischaemia
OT  - nanoparticles
OT  - topical haemoglobin
OT  - topical oxygen therapy
OT  - user safety
EDAT- 2019/03/07 06:00
MHDA- 2019/12/18 06:00
CRDT- 2019/03/07 06:00
PHST- 2019/03/07 06:00 [entrez]
PHST- 2019/03/07 06:00 [pubmed]
PHST- 2019/12/18 06:00 [medline]
AID - 10.12968/jowc.2019.28.3.148 [doi]
PST - ppublish
SO  - J Wound Care. 2019 Mar 3;28(3):148-153. doi: 10.12968/jowc.2019.28.3.148.