PMID- 30841917 OWN - NLM STAT- MEDLINE DCOM- 20200505 LR - 20231006 IS - 2046-4053 (Electronic) IS - 2046-4053 (Linking) VI - 8 IP - 1 DP - 2019 Mar 6 TI - Traditional knowledge-based lifestyle interventions in the prevention of obesity and type 2 diabetes in Indigenous children in Canada: a systematic review protocol. PG - 69 LID - 10.1186/s13643-019-0961-4 [doi] LID - 69 AB - BACKGROUND: Approximately 50% of all youth-onset type 2 diabetes mellitus (T2DM) in Canada occurs in Indigenous children. In adults, cardiovascular disease is one of the leading causes of mortality in First Nations communities, and diabetes is a significant contributor to the risk of developing this disorder. The early onset of diabetes may predispose these children to premature cardiovascular disease and influence their longevity and quality of life. As a result, the implementation of culturally tailored obesity and T2DM primary prevention programs is vital. This systematic review aims to assess the effectiveness of existing traditional knowledge-based lifestyle intervention programs on preventing obesity and T2DM in Indigenous children in Canada. METHODS: We will conduct database searches in MEDLINE, Embase, PsycINFO, SPORTDiscus, CINAHL, Web of Science, Cochrane Database of Systematic Reviews, and the Cochrane Controlled Register of Trials. We will also conduct grey literature searches of central repository of trials ( ClinicalTrials.gov ), ProQuest Dissertations, Theses A&I, and Indigenous studies portal research tools. Reviewers will independently review titles, abstracts, and full-text articles retrieved from databases to assess potentially eligible studies, and relevant articles will be assessed for risk of bias and quality. The primary outcomes include the change in body mass index z-scores or a diagnosis of diabetes. The secondary outcomes include the change in measures of adiposity as well as lifestyle and metabolic profiles. A meta-analysis will be performed if two or more studies have used similar study designs, comparable intervention techniques , similar populations and measured similar outcomes. DISCUSSION: This review will provide a summary of current interventions to prevent obesity and T2DM in Indigenous children in Canada and help determine the gaps in the literature so that interventions can be developed to control the surge in pediatric T2DM in Indigenous communities. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42017072781. FAU - Crawford, Rebecca AU - Crawford R AD - Department of Pediatrics, McMaster University, 1280 Main Street West, HSC-3A57, Hamilton, Ontario, L8S 4K1, Canada. AD - Division of Pediatric Endocrinology, McMaster Children's Hospital, Hamilton, Ontario, Canada. AD - Indigenous Undergraduate Summer Research Scholars Program, Hamilton, Ontario, Canada. FAU - Sims, E Danielle AU - Sims ED AD - Department of Pediatrics, McMaster University, 1280 Main Street West, HSC-3A57, Hamilton, Ontario, L8S 4K1, Canada. AD - Division of Pediatric Endocrinology, McMaster Children's Hospital, Hamilton, Ontario, Canada. AD - Medical Sciences Graduate Program, McMaster University, Hamilton, Ontario, Canada. FAU - Wang, Kuan-Wen AU - Wang KW AD - Department of Pediatrics, McMaster University, 1280 Main Street West, HSC-3A57, Hamilton, Ontario, L8S 4K1, Canada. AD - Division of Pediatric Endocrinology, McMaster Children's Hospital, Hamilton, Ontario, Canada. AD - Medical Sciences Graduate Program, McMaster University, Hamilton, Ontario, Canada. FAU - Youssef, Michael AU - Youssef M AD - Department of Pediatrics, McMaster University, 1280 Main Street West, HSC-3A57, Hamilton, Ontario, L8S 4K1, Canada. AD - Division of Pediatric Endocrinology, McMaster Children's Hospital, Hamilton, Ontario, Canada. FAU - Nadarajah, Ajantha AU - Nadarajah A AD - Department of Pediatrics, McMaster University, 1280 Main Street West, HSC-3A57, Hamilton, Ontario, L8S 4K1, Canada. AD - Division of Pediatric Endocrinology, McMaster Children's Hospital, Hamilton, Ontario, Canada. FAU - Rivas, Angelica AU - Rivas A AD - Department of Pediatrics, McMaster University, 1280 Main Street West, HSC-3A57, Hamilton, Ontario, L8S 4K1, Canada. AD - Division of Pediatric Endocrinology, McMaster Children's Hospital, Hamilton, Ontario, Canada. FAU - Banfield, Laura AU - Banfield L AD - Health Sciences Library, McMaster University, Hamilton, Ontario, Canada. FAU - Thabane, Lehana AU - Thabane L AD - Department of Pediatrics, McMaster University, 1280 Main Street West, HSC-3A57, Hamilton, Ontario, L8S 4K1, Canada. AD - Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada. AD - Department of Anesthesia, McMaster University, Hamilton, Ontario, Canada. AD - Centre for Evaluation of Medicines, St. Joseph's Health Care, Hamilton, Ontario, Canada. AD - Biostatistics Unit, St. Joseph's Healthcare, Hamilton, Ontario, Canada. FAU - Samaan, M Constantine AU - Samaan MC AUID- ORCID: 0000-0002-6403-4715 AD - Department of Pediatrics, McMaster University, 1280 Main Street West, HSC-3A57, Hamilton, Ontario, L8S 4K1, Canada. samaanc@mcmaster.ca. AD - Division of Pediatric Endocrinology, McMaster Children's Hospital, Hamilton, Ontario, Canada. samaanc@mcmaster.ca. AD - Medical Sciences Graduate Program, McMaster University, Hamilton, Ontario, Canada. samaanc@mcmaster.ca. AD - Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada. samaanc@mcmaster.ca. LA - eng GR - CIHR/Canada PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20190306 PL - England TA - Syst Rev JT - Systematic reviews JID - 101580575 SB - IM MH - Canada MH - Child MH - Diabetes Mellitus, Type 2/*prevention & control MH - Health Promotion/*methods MH - Humans MH - *Indigenous Peoples MH - *Life Style MH - Pediatric Obesity/*prevention & control MH - Program Evaluation MH - Research Design MH - Systematic Reviews as Topic PMC - PMC6402164 OTO - NOTNLM OT - Indigenous OT - Intervention OT - Pediatric OT - Primary prevention OT - Systematic review OT - Type 2 diabetes mellitus COIS- ETHICS APPROVAL AND CONSENT TO PARTICIPATE: Not applicable CONSENT FOR PUBLICATION: Not applicable COMPETING INTERESTS: The authors declare that they have no competing interests. PUBLISHER'S NOTE: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. EDAT- 2019/03/08 06:00 MHDA- 2020/05/06 06:00 PMCR- 2019/03/06 CRDT- 2019/03/08 06:00 PHST- 2017/09/13 00:00 [received] PHST- 2019/01/23 00:00 [accepted] PHST- 2019/03/08 06:00 [entrez] PHST- 2019/03/08 06:00 [pubmed] PHST- 2020/05/06 06:00 [medline] PHST- 2019/03/06 00:00 [pmc-release] AID - 10.1186/s13643-019-0961-4 [pii] AID - 961 [pii] AID - 10.1186/s13643-019-0961-4 [doi] PST - epublish SO - Syst Rev. 2019 Mar 6;8(1):69. doi: 10.1186/s13643-019-0961-4.