PMID- 30842172
OWN - NLM
STAT- MEDLINE
DCOM- 20190311
LR  - 20190311
IS  - 1791-7530 (Electronic)
IS  - 0250-7005 (Linking)
VI  - 39
IP  - 3
DP  - 2019 Mar
TI  - Rectus Sheath Block (RSB) Analgesia Could Enhance Significantly the Patient 
      Satisfaction Following Midline Laparotomy in Benign Disease and in Cancer: A 
      Prospective Study With Special Reference to Nitrosative Stress Marker 
      Nitrotyrosine (NT) Plasma Concentrations.
PG  - 1383-1389
LID - 10.21873/anticanres.13252 [doi]
AB  - BACKGROUND/AIM: Our hypothesis was that rectus sheath block (RSB) analgesia could 
      enhance satisfaction following midline laparotomy in patients with benign disease 
      and cancer patients. PATIENTS AND METHODS: Initially, 56 patients were randomized 
      into four groups; control group (n=12), single-dose (n=16), repeated-dose (n=12) 
      and continuous infusion (n=16) RSB analgesia groups. The plasma concentrations of 
      the NT marker were measured just before, immediately after and 24 h after 
      operation. Patient satisfaction at 24 h postoperatively was filed on a 11-point 
      numeric rating scale (SFS(24); 0=fully unsatisfied; 10=fully satisfied). RESULTS: 
      The RSB analgesia significantly enhanced the SFS(24) scores in the study groups 
      (p=0.001). The median plasma NT concentrations (pg/ml) following surgery (POP1) 
      were significantly lower in patients with cancer versus patients with benign 
      disease (5.3 vs. 7.6, p=0.008). Jitter plots of the individual SFS(24) values 
      versus plasma NT concentrations were significantly correlated in benign and 
      cancer patients (r=-0.284, p=0.028). CONCLUSION: The RSB analgesia could 
      significantly enhance patient satisfaction following midline laparotomy. Plasma 
      NT concentrations versus patient satisfaction following surgery are significantly 
      correlated in benign disease and cancer.
CI  - Copyright(c) 2019, International Institute of Anticancer Research (Dr. George J. 
      Delinasios), All rights reserved.
FAU - Kuosmanen, Viivi
AU  - Kuosmanen V
AD  - Department of Surgery, Kuopio University Hospital and School of Medicine, 
      University of Eastern Finland, Kuopio, Finland.
FAU - Saimanen, Iina
AU  - Saimanen I
AD  - Department of Surgery, Kuopio University Hospital and School of Medicine, 
      University of Eastern Finland, Kuopio, Finland.
FAU - Rahkola, Dina
AU  - Rahkola D
AD  - Department of Surgery, Kuopio University Hospital and School of Medicine, 
      University of Eastern Finland, Kuopio, Finland.
FAU - Karkkainen, Jari
AU  - Karkkainen J
AD  - Department of Surgery, Kuopio University Hospital and School of Medicine, 
      University of Eastern Finland, Kuopio, Finland.
FAU - Selander, Tuomas
AU  - Selander T
AD  - Science Service Center, Kuopio University Hospital, Kuopio, Finland.
FAU - Purdy, Martin
AU  - Purdy M
AD  - Department of Surgery, Kuopio University Hospital and School of Medicine, 
      University of Eastern Finland, Kuopio, Finland.
FAU - Kokki, Hannu
AU  - Kokki H
AD  - Department of Anaesthesia and Operative Services, Kuopio University Hospital and 
      School of Medicine, University of Eastern Finland, Kuopio, Finland.
FAU - Kokki, Merja
AU  - Kokki M
AD  - Department of Anaesthesia and Operative Services, Kuopio University Hospital and 
      School of Medicine, University of Eastern Finland, Kuopio, Finland.
FAU - Eskelinen, Matti
AU  - Eskelinen M
AD  - Department of Surgery, Kuopio University Hospital and School of Medicine, 
      University of Eastern Finland, Kuopio, Finland matti.eskelinen@kuh.fi.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
RN  - 3604-79-3 (3-nitrotyrosine)
RN  - 42HK56048U (Tyrosine)
SB  - IM
MH  - Aged
MH  - Analgesia
MH  - Female
MH  - Humans
MH  - Laparotomy
MH  - Male
MH  - Middle Aged
MH  - Neoplasms/blood/*surgery
MH  - *Nerve Block
MH  - Nitrosative Stress
MH  - *Rectus Abdominis
MH  - Tyrosine/*analogs & derivatives/blood
OTO - NOTNLM
OT  - Benign disease
OT  - cancer
OT  - nitrosative stress
OT  - plasma nitrotyrosine
OT  - satisfaction following surgery
EDAT- 2019/03/08 06:00
MHDA- 2019/03/12 06:00
CRDT- 2019/03/08 06:00
PHST- 2019/02/04 00:00 [received]
PHST- 2019/02/18 00:00 [revised]
PHST- 2019/02/19 00:00 [accepted]
PHST- 2019/03/08 06:00 [entrez]
PHST- 2019/03/08 06:00 [pubmed]
PHST- 2019/03/12 06:00 [medline]
AID - 39/3/1383 [pii]
AID - 10.21873/anticanres.13252 [doi]
PST - ppublish
SO  - Anticancer Res. 2019 Mar;39(3):1383-1389. doi: 10.21873/anticanres.13252.