PMID- 30842390
OWN - NLM
STAT- MEDLINE
DCOM- 20190729
LR  - 20200225
IS  - 1941-5923 (Electronic)
IS  - 1941-5923 (Linking)
VI  - 20
DP  - 2019 Mar 7
TI  - Azathioprine During the First Trimester of Pregnancy in a Patient with 
      Vogt-Koyanagi-Harada Disease: A Multimodal Imaging Follow-Up Study.
PG  - 300-305
LID - 10.12659/AJCR.914281 [doi]
AB  - BACKGROUND The aim of this study was to describe the case of a 27-year-old woman 
      who developed Vogt-Koyanagi-Harada (VKH) disease in the 13th week of pregnancy, 
      who was treated with high-dose oral corticosteroids and azathioprine due to its 
      persistent course. CASE REPORT A 27-year-old East Indian woman in her 13th week 
      of pregnancy presented with bilateral decreased visual acuity and metamorphopsia 
      due to bilateral serous retinal detachments and was diagnosed with 
      Vogt-Koyanagi-Harada (VKH) disease. Multimodal imaging, including blue light 
      fundus autofluorescence (FAF), structural spectral domain optical coherence 
      tomography (SD-OCT), en-face OCT, and OCT angiography (OCT-A), was performed at 
      presentation and follow-up, being particularly helpful for identifying 
      recurrences. Her treatment consisted of high-dose corticosteroid therapy, and 
      azathioprine had to be added as an adjuvant due to the aggressive behavior of the 
      disease. She gave birth to a healthy baby at 31 weeks of gestation and remained 
      with 20/20 vision at 8 weeks postpartum. CONCLUSIONS To the best of our 
      knowledge, this is the first report on the use of azathioprine in VKH disease 
      during pregnancy with a successful outcome. Multimodal imaging avoiding the use 
      of fundus fluorescein angiography is key in the diagnosis and follow-up of VKH 
      disease in pregnant women.
FAU - Ingolotti, Mariana
AU  - Ingolotti M
AD  - Department of Ophthalmology, Hospital Civil Fray Antonio Alcalde, Guadalajara, 
      Jalisco, Mexico.
FAU - Schlaen, Bernardo A
AU  - Schlaen BA
AD  - Department of Ophthalmology, Hospital Universitario Austral, Buenos Aires, 
      Argentina.
FAU - Roig Melo-Granados, Enrique Alfonso
AU  - Roig Melo-Granados EA
AD  - Department of Ophthalmology, Hospital Civil Fray Antonio Alcalde, Guadalajara, 
      Jalisco, Mexico.
AD  - Clinica Oftalmologica (Ophthalmological Clinic) Santa Lucia, Guadalajara, 
      Jalisco, Mexico.
FAU - Ruiz Garcia, Humberto
AU  - Ruiz Garcia H
AD  - Clinica Oftalmologica (Ophthalmological Clinic) Santa Lucia, Guadalajara, 
      Jalisco, Mexico.
FAU - Aguilera Partida, Jorge Arturo
AU  - Aguilera Partida JA
AD  - Clinica Oftalmologica (Ophthalmological Clinic) Santa Lucia, Guadalajara, 
      Jalisco, Mexico.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20190307
PL  - United States
TA  - Am J Case Rep
JT  - The American journal of case reports
JID - 101489566
RN  - 0 (Immunosuppressive Agents)
RN  - MRK240IY2L (Azathioprine)
MH  - Adult
MH  - Angiography
MH  - Azathioprine/*therapeutic use
MH  - Female
MH  - Humans
MH  - Immunosuppressive Agents/*therapeutic use
MH  - Multimodal Imaging
MH  - Pregnancy
MH  - Pregnancy Complications/*diagnostic imaging/*drug therapy
MH  - Pregnancy Trimester, First
MH  - Tomography, Optical Coherence
MH  - Uveomeningoencephalitic Syndrome/*diagnostic imaging/*drug therapy
PMC - PMC6419529
COIS- Conflict of interest: None declared Conflict of interest None.
EDAT- 2019/03/08 06:00
MHDA- 2019/07/30 06:00
PMCR- 2018/03/07
CRDT- 2019/03/08 06:00
PHST- 2019/03/08 06:00 [entrez]
PHST- 2019/03/08 06:00 [pubmed]
PHST- 2019/07/30 06:00 [medline]
PHST- 2018/03/07 00:00 [pmc-release]
AID - 914281 [pii]
AID - 10.12659/AJCR.914281 [doi]
PST - epublish
SO  - Am J Case Rep. 2019 Mar 7;20:300-305. doi: 10.12659/AJCR.914281.