PMID- 30842426
OWN - NLM
STAT- MEDLINE
DCOM- 20190409
LR  - 20200309
IS  - 2041-1723 (Electronic)
IS  - 2041-1723 (Linking)
VI  - 10
IP  - 1
DP  - 2019 Mar 6
TI  - Multispectral optoacoustic imaging of dynamic redox correlation and 
      pathophysiological progression utilizing upconversion nanoprobes.
PG  - 1087
LID - 10.1038/s41467-019-09001-7 [doi]
LID - 1087
AB  - Precise and differential profiling of the dynamic correlations and 
      pathophysiological implications of multiplex biological mediators with deep 
      penetration and highly programmed precision remain critical challenges in 
      clinics. Here we present an innovative strategy by tailoring a powerful 
      multispectral optoacoustic tomography (MSOT) technique with a photon-upconverting 
      nanoprobe (UCN) for simultaneous visualization of diversely endogenous redox 
      biomarkers with excellent spatiotemporal resolution in living conditions. Upon 
      incorporating two specific radicals-sensitive NIR cyanine fluorophores onto UCNs 
      surface, such nanoprobes can orthogonally respond to disparate oxidative and 
      nitrosative stimulation, and generate spectrally opposite optoacoustic signal 
      variations, which thus achieves compelling superiorities for reversed ratiometric 
      tracking of multiple radicals under dual independent wavelength channels, and 
      significantly, for precise validating of their complex dynamics and correlations 
      with redox-mediated pathophysiological procession in vivo.
FAU - Ai, Xiangzhao
AU  - Ai X
AUID- ORCID: 0000-0002-7205-3748
AD  - Sino-Singapore International Joint Research Institute (SSIJRI), Guangzhou, 
      510000, China.
AD  - Division of Chemistry and Biological Chemistry, School of Physical and 
      Mathematical Sciences, Nanyang Technological University, Singapore, 637371, 
      Singapore.
FAU - Wang, Zhimin
AU  - Wang Z
AD  - Division of Chemistry and Biological Chemistry, School of Physical and 
      Mathematical Sciences, Nanyang Technological University, Singapore, 637371, 
      Singapore.
FAU - Cheong, Haolun
AU  - Cheong H
AD  - Division of Chemistry and Biological Chemistry, School of Physical and 
      Mathematical Sciences, Nanyang Technological University, Singapore, 637371, 
      Singapore.
FAU - Wang, Yong
AU  - Wang Y
AUID- ORCID: 0000-0003-4061-7956
AD  - State Key Laboratory of Radiation Medicine and Protection, School for 
      Radiological and Interdisciplinary Sciences (RAD-X), Soochow University, Suzhou, 
      215123, China.
FAU - Zhang, Ruochong
AU  - Zhang R
AD  - School of Electrical and Electronic Engineering, Nanyang Technological 
      University, 50 Nanyang Avenue, Singapore, 639798, Singapore.
FAU - Lin, Jun
AU  - Lin J
AD  - State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of 
      Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.
FAU - Zheng, Yuanjin
AU  - Zheng Y
AD  - School of Electrical and Electronic Engineering, Nanyang Technological 
      University, 50 Nanyang Avenue, Singapore, 639798, Singapore.
FAU - Gao, Mingyuan
AU  - Gao M
AD  - State Key Laboratory of Radiation Medicine and Protection, School for 
      Radiological and Interdisciplinary Sciences (RAD-X), Soochow University, Suzhou, 
      215123, China. gaomy@iccas.ac.cn.
FAU - Xing, Bengang
AU  - Xing B
AD  - Sino-Singapore International Joint Research Institute (SSIJRI), Guangzhou, 
      510000, China. bengang@ntu.edu.sg.
AD  - Division of Chemistry and Biological Chemistry, School of Physical and 
      Mathematical Sciences, Nanyang Technological University, Singapore, 637371, 
      Singapore. bengang@ntu.edu.sg.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190306
PL  - England
TA  - Nat Commun
JT  - Nature communications
JID - 101528555
RN  - 0 (Biomarkers)
RN  - 0 (Fluorescent Dyes)
RN  - 0 (Molecular Probes)
SB  - IM
MH  - Animals
MH  - Biomarkers/analysis
MH  - Disease Models, Animal
MH  - Female
MH  - Fluorescent Dyes/administration & dosage/chemistry
MH  - Heart/diagnostic imaging
MH  - Humans
MH  - Inflammation/*diagnostic imaging/immunology/pathology
MH  - Kidney/diagnostic imaging/pathology
MH  - Liver/diagnostic imaging/pathology
MH  - Lung/diagnostic imaging/pathology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Nude
MH  - Molecular Probes/administration & dosage/*chemistry
MH  - Nanoparticles/administration & dosage/*chemistry
MH  - Oxidation-Reduction
MH  - Photoacoustic Techniques/*methods
MH  - *Photons
MH  - RAW 264.7 Cells
MH  - Spectroscopy, Near-Infrared/methods
MH  - Spleen/diagnostic imaging/pathology
MH  - Theranostic Nanomedicine/methods
MH  - Tomography, X-Ray Computed/methods
PMC - PMC6403272
COIS- The authors declare no competing interests.
EDAT- 2019/03/08 06:00
MHDA- 2019/04/10 06:00
PMCR- 2019/03/06
CRDT- 2019/03/08 06:00
PHST- 2018/06/21 00:00 [received]
PHST- 2019/02/06 00:00 [accepted]
PHST- 2019/03/08 06:00 [entrez]
PHST- 2019/03/08 06:00 [pubmed]
PHST- 2019/04/10 06:00 [medline]
PHST- 2019/03/06 00:00 [pmc-release]
AID - 10.1038/s41467-019-09001-7 [pii]
AID - 9001 [pii]
AID - 10.1038/s41467-019-09001-7 [doi]
PST - epublish
SO  - Nat Commun. 2019 Mar 6;10(1):1087. doi: 10.1038/s41467-019-09001-7.