PMID- 30842806
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1948-0210 (Print)
IS  - 1948-0210 (Electronic)
IS  - 1948-0210 (Linking)
VI  - 11
IP  - 2
DP  - 2019 Feb 26
TI  - Human cord blood-derived viral pathogens as the potential threats to the 
      hematopoietic stem cell transplantation safety: A mini review.
PG  - 73-83
LID - 10.4252/wjsc.v11.i2.73 [doi]
AB  - Umbilical cord blood (UCB) is a valuable source of hematopoietic stem cells 
      (HSCs) and potential alternative for bone marrow transplantation for patients who 
      lack human leukocyte antigen (HLA)-matched donors. The main practical advantages 
      of UCB over other HSC sources are the immediate availability, lower incidence of 
      graft-versus-host disease, minimal risk to the donor, and lower requirement for 
      HLA compatibility. However, the use of UCB is limited by delayed engraftment and 
      poor immune reconstitution, leading to a high rate of infection-related 
      mortality. Therefore, severe infectious complications, especially due to viral 
      pathogens remain the leading cause of morbidity and mortality during the post-UCB 
      transplantation (UCBT) period. In this context, careful screening and excluding 
      the viral-contaminated UCB units might be an effective policy to reduce the rate 
      of UCBT-related infection and mortality. Taken together, complete prevention of 
      the transmission of donor-derived viral pathogens in stem cell transplantation is 
      not possible. However, having the knowledge of the transmission route and 
      prevalence of viruses will improve the safety of transplantation. To the best of 
      our knowledge, there are few studies that focused on the risk of virus 
      transmission through the UCB transplant compared to other HSC sources. This 
      review summarizes the general aspects concerning the prevalence, characteristics, 
      and risk factors of viral infections with a focus on the impact of viral 
      pathogens on cord blood transplantation safety.
FAU - Noroozi-Aghideh, Ali
AU  - Noroozi-Aghideh A
AD  - Department of Hematology, Faculty of Paramedicine, Aja University of Medical 
      Sciences, Tehran 14665-1157, Iran.
FAU - Kheirandish, Maryam
AU  - Kheirandish M
AD  - Immunology Department, Blood Transfusion Research Center, High Institute for 
      Research and Education in Transfusion Medicine (IBTO), Tehran 14665-1157, Iran. 
      m.kheirandish@ibto.ir.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - World J Stem Cells
JT  - World journal of stem cells
JID - 101535826
PMC - PMC6397803
OTO - NOTNLM
OT  - Cord blood
OT  - Transplantation safety
OT  - Viral pathogens
COIS- Conflict-of-interest statement: Authors of this manuscript have no conflicts of 
      interest to disclose.
EDAT- 2019/03/08 06:00
MHDA- 2019/03/08 06:01
PMCR- 2019/02/26
CRDT- 2019/03/08 06:00
PHST- 2018/12/12 00:00 [received]
PHST- 2019/01/14 00:00 [revised]
PHST- 2019/01/26 00:00 [accepted]
PHST- 2019/03/08 06:00 [entrez]
PHST- 2019/03/08 06:00 [pubmed]
PHST- 2019/03/08 06:01 [medline]
PHST- 2019/02/26 00:00 [pmc-release]
AID - 10.4252/wjsc.v11.i2.73 [doi]
PST - ppublish
SO  - World J Stem Cells. 2019 Feb 26;11(2):73-83. doi: 10.4252/wjsc.v11.i2.73.