PMID- 30843393
OWN - NLM
STAT- MEDLINE
DCOM- 20190712
LR  - 20190712
IS  - 1944-8252 (Electronic)
IS  - 1944-8244 (Linking)
VI  - 11
IP  - 12
DP  - 2019 Mar 27
TI  - Aggregation-Induced Emission Luminogens with the Capability of Wide Color Tuning, 
      Mitochondrial and Bacterial Imaging, and Photodynamic Anticancer and 
      Antibacterial Therapy.
PG  - 11227-11237
LID - 10.1021/acsami.9b01655 [doi]
AB  - Recently, luminogens with the aggregation-induced emission characteristic 
      (AIEgens) have received much attention in the field of bioimaging and therapeutic 
      applications. However, the development of AIEgens that are derived from the 
      simple core skeleton with emission color tuning for imaging and therapy is still 
      a formidable challenge. To address this constraint, we present a series of 
      cationic AIEgens based on cyanopyridinium salts (CP1-CP5). The AIEgens can be 
      facilely prepared by varying the aromatic electron donor while fixing the 
      cyanopyridinium group as the electron acceptor within a single benzene ring. The 
      obtained AIEgens possess wide color tunability, large Stokes shifts, and bright 
      emission in the condensed state. Due to their good biocompatibility and cationic 
      nature, these AIEgens can be utilized for multiple-color imaging of intracellular 
      mitochondria as well as Gram-negative and Gram-positive bacteria. Importantly, 
      these AIEgens exhibit remarkable structure-dependent singlet-oxygen generation 
      ability under white light illumination (25 mW cm(-2)), and CP4 was optimized to 
      serve as an excellent photosensitizer for photodynamic anticancer and 
      antibacterial therapy.
FAU - Zhao, Na
AU  - Zhao N
AUID- ORCID: 0000-0001-7347-5865
AD  - Key Laboratory of Macromolecular Science of Shaanxi Province, Key Laboratory of 
      Applied Surface and Colloid Chemistry of Ministry of Education, Key Laboratory of 
      the Ministry of Education for Medicinal Resources and Natural Pharmaceutical 
      Chemistry, and School of Chemistry & Chemical Engineering , Shaanxi Normal 
      University , Xi'an 710119 , China.
FAU - Li, Pengfei
AU  - Li P
AD  - Key Laboratory of Macromolecular Science of Shaanxi Province, Key Laboratory of 
      Applied Surface and Colloid Chemistry of Ministry of Education, Key Laboratory of 
      the Ministry of Education for Medicinal Resources and Natural Pharmaceutical 
      Chemistry, and School of Chemistry & Chemical Engineering , Shaanxi Normal 
      University , Xi'an 710119 , China.
FAU - Zhuang, Jiabao
AU  - Zhuang J
AD  - Key Laboratory of Macromolecular Science of Shaanxi Province, Key Laboratory of 
      Applied Surface and Colloid Chemistry of Ministry of Education, Key Laboratory of 
      the Ministry of Education for Medicinal Resources and Natural Pharmaceutical 
      Chemistry, and School of Chemistry & Chemical Engineering , Shaanxi Normal 
      University , Xi'an 710119 , China.
FAU - Liu, Yanyan
AU  - Liu Y
AD  - Key Laboratory of Macromolecular Science of Shaanxi Province, Key Laboratory of 
      Applied Surface and Colloid Chemistry of Ministry of Education, Key Laboratory of 
      the Ministry of Education for Medicinal Resources and Natural Pharmaceutical 
      Chemistry, and School of Chemistry & Chemical Engineering , Shaanxi Normal 
      University , Xi'an 710119 , China.
FAU - Xiao, Yuxin
AU  - Xiao Y
AD  - Key Laboratory of Macromolecular Science of Shaanxi Province, Key Laboratory of 
      Applied Surface and Colloid Chemistry of Ministry of Education, Key Laboratory of 
      the Ministry of Education for Medicinal Resources and Natural Pharmaceutical 
      Chemistry, and School of Chemistry & Chemical Engineering , Shaanxi Normal 
      University , Xi'an 710119 , China.
FAU - Qin, Ruilin
AU  - Qin R
AD  - Key Laboratory of Macromolecular Science of Shaanxi Province, Key Laboratory of 
      Applied Surface and Colloid Chemistry of Ministry of Education, Key Laboratory of 
      the Ministry of Education for Medicinal Resources and Natural Pharmaceutical 
      Chemistry, and School of Chemistry & Chemical Engineering , Shaanxi Normal 
      University , Xi'an 710119 , China.
FAU - Li, Nan
AU  - Li N
AUID- ORCID: 0000-0003-1091-0086
AD  - Key Laboratory of Macromolecular Science of Shaanxi Province, Key Laboratory of 
      Applied Surface and Colloid Chemistry of Ministry of Education, Key Laboratory of 
      the Ministry of Education for Medicinal Resources and Natural Pharmaceutical 
      Chemistry, and School of Chemistry & Chemical Engineering , Shaanxi Normal 
      University , Xi'an 710119 , China.
LA  - eng
PT  - Journal Article
DEP - 20190319
PL  - United States
TA  - ACS Appl Mater Interfaces
JT  - ACS applied materials & interfaces
JID - 101504991
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Fluorescent Dyes)
RN  - 0 (Photosensitizing Agents)
RN  - 0 (Pyridinium Compounds)
RN  - 17778-80-2 (Singlet Oxygen)
SB  - IM
MH  - Anti-Bacterial Agents/*chemistry/pharmacology
MH  - Cell Survival/drug effects/radiation effects
MH  - Drug Design
MH  - Fluorescent Dyes/*chemistry/pharmacology
MH  - Gram-Negative Bacteria/drug effects
MH  - Gram-Positive Bacteria/drug effects
MH  - HeLa Cells
MH  - Humans
MH  - Light
MH  - Microscopy, Confocal
MH  - Mitochondria/drug effects/pathology
MH  - Photosensitizing Agents/*chemistry/pharmacology
MH  - Pyridinium Compounds/chemistry
MH  - Quantum Theory
MH  - Singlet Oxygen/metabolism
OTO - NOTNLM
OT  - aggregation-induced emission
OT  - bacterial imaging
OT  - mitochondrial imaging
OT  - photosensitizer
OT  - wide color tuning
EDAT- 2019/03/08 06:00
MHDA- 2019/07/13 06:00
CRDT- 2019/03/08 06:00
PHST- 2019/03/08 06:00 [pubmed]
PHST- 2019/07/13 06:00 [medline]
PHST- 2019/03/08 06:00 [entrez]
AID - 10.1021/acsami.9b01655 [doi]
PST - ppublish
SO  - ACS Appl Mater Interfaces. 2019 Mar 27;11(12):11227-11237. doi: 
      10.1021/acsami.9b01655. Epub 2019 Mar 19.