PMID- 30843733
OWN - NLM
STAT- MEDLINE
DCOM- 20190722
LR  - 20231006
IS  - 1521-0464 (Electronic)
IS  - 1071-7544 (Print)
IS  - 1071-7544 (Linking)
VI  - 26
IP  - 1
DP  - 2019 Dec
TI  - Intra-articular injection of triamcinolone acetonide releasing biomaterial 
      microspheres inhibits pain and inflammation in an acute arthritis model.
PG  - 226-236
AB  - Inflammation of the synovium and joint capsule is a main driver of pain in an 
      osteoarthritic (OA) joint. Triamcinolone acetonide (TAA) is a classical 
      corticosteroid that reduces synovitis and alleviates pain, albeit transiently. 
      Biomaterial-based local TAA release may prolong the suppression of pain without 
      the need for multiple injections. Polylactic-co-glycolic acid (PLGA) formulations 
      of TAA prolong OA pain relief to a limited extent. A novel polyesteramide (PEA) 
      microsphere platform allows for extended release in the OA joint for over 
      3 months. To evaluate their effect on pain and inflammation, TAA-loaded 
      microspheres were intra-articularly delivered to the knee joint in a rat model of 
      acute arthritis induced by intra-articular injection of streptococcal cell wall 
      peptidoglycan-polysaccharide (PGPS) and subsequent flare-ups by intravenous PGPS 
      injections. PEA-loaded microspheres were benchmarked with TAA-loaded PLGA 
      microspheres and bolus TAA injection. TAA treatments were injected 
      intra-articularly before the first induced flare-up. TAA-loaded PEA and PLGA 
      microspheres reduced joint swelling and signs of pain-like behavior over the 
      entire study period, as assessed by weight bearing and referred mechanical 
      hypersensitivity, whereas bolus suspension was effective for a shorter time 
      period. TAA-loaded PEA microspheres reduced lameness to a greater extent than 
      TAA-loaded PLGA microspheres. In conclusion, a single intra-articular injection 
      of TAA-loaded PEA microspheres reduced joint swelling and induced longer pain 
      relief compared to bolus injection. Hence relief of inflammation and pain by 
      PEA-based delivery of TAA may prove to be effective and durable.
FAU - Rudnik-Jansen, Imke
AU  - Rudnik-Jansen I
AUID- ORCID: 0000-0002-2508-3610
AD  - a Department of Orthopedics , University Medical Center Utrecht , Utrecht , the 
      Netherlands.
FAU - Schrijver, Karin
AU  - Schrijver K
AD  - a Department of Orthopedics , University Medical Center Utrecht , Utrecht , the 
      Netherlands.
FAU - Woike, Nina
AU  - Woike N
AD  - b DSM Biomedical B.V , Geleen , The Netherlands.
FAU - Tellegen, Anna
AU  - Tellegen A
AUID- ORCID: 0000-0002-8836-097X
AD  - c Department of Clinical Sciences of Companion Animals , Utrecht University , 
      Utrecht , the Netherlands.
FAU - Versteeg, Sabine
AU  - Versteeg S
AD  - d Laboratory of Translational Immunology , University Medical Center Utrecht, 
      Utrecht University , Utrecht , the Netherlands.
FAU - Emans, Pieter
AU  - Emans P
AUID- ORCID: 0000-0001-9370-5525
AD  - e Department of Orthopedics , Maastricht University Medical Center Utrecht , 
      Utrecht , the Netherlands.
FAU - Mihov, George
AU  - Mihov G
AD  - b DSM Biomedical B.V , Geleen , The Netherlands.
FAU - Thies, Jens
AU  - Thies J
AD  - b DSM Biomedical B.V , Geleen , The Netherlands.
FAU - Eijkelkamp, Niels
AU  - Eijkelkamp N
AD  - d Laboratory of Translational Immunology , University Medical Center Utrecht, 
      Utrecht University , Utrecht , the Netherlands.
FAU - Tryfonidou, Marianna
AU  - Tryfonidou M
AUID- ORCID: 0000-0002-2333-7162
AD  - c Department of Clinical Sciences of Companion Animals , Utrecht University , 
      Utrecht , the Netherlands.
FAU - Creemers, Laura
AU  - Creemers L
AD  - a Department of Orthopedics , University Medical Center Utrecht , Utrecht , the 
      Netherlands.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Drug Deliv
JT  - Drug delivery
JID - 9417471
RN  - 0 (Acrylic Resins)
RN  - 0 (Biocompatible Materials)
RN  - 0 (poly(ethylacrylate))
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - F446C597KA (Triamcinolone Acetonide)
SB  - IM
MH  - Acrylic Resins/chemistry
MH  - Animals
MH  - Biocompatible Materials/chemistry/*pharmacology
MH  - Disease Models, Animal
MH  - Female
MH  - Inflammation/*drug therapy
MH  - Injections, Intra-Articular/methods
MH  - Knee Joint/drug effects
MH  - Microspheres
MH  - Osteoarthritis/*drug therapy
MH  - Pain/*drug therapy
MH  - Polylactic Acid-Polyglycolic Acid Copolymer/chemistry
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Synovial Membrane/drug effects
MH  - Triamcinolone Acetonide/chemistry/*pharmacology
PMC - PMC6407600
OTO - NOTNLM
OT  - Arthritis
OT  - microspheres
OT  - polyesteramide
OT  - polylactic-co-glycolic acid
OT  - synovitis
OT  - triamcinolone acetonide
EDAT- 2019/03/08 06:00
MHDA- 2019/07/23 06:00
PMCR- 2019/03/07
CRDT- 2019/03/08 06:00
PHST- 2019/03/08 06:00 [entrez]
PHST- 2019/03/08 06:00 [pubmed]
PHST- 2019/07/23 06:00 [medline]
PHST- 2019/03/07 00:00 [pmc-release]
AID - 10.1080/10717544.2019.1568625 [pii]
AID - 1568625 [pii]
AID - 10.1080/10717544.2019.1568625 [doi]
PST - ppublish
SO  - Drug Deliv. 2019 Dec;26(1):226-236. doi: 10.1080/10717544.2019.1568625.