PMID- 30844469 OWN - NLM STAT- MEDLINE DCOM- 20190708 LR - 20221207 IS - 1872-8227 (Electronic) IS - 0168-8227 (Linking) VI - 150 DP - 2019 Apr TI - Evaluation of myocardial fibrosis in diabetes with cardiac magnetic resonance T1-mapping: Correlation with the high-level hemoglobin A1c. PG - 72-80 LID - S0168-8227(18)31302-0 [pii] LID - 10.1016/j.diabres.2019.03.004 [doi] AB - AIM: The aim of the study was to assess the extracellular volume fraction (ECV) in type 2 diabetes mellitus (T2DM) patients with different level of hemoglobin A1c (HbA1c) by cardiac magnetic resonance (CMR), and the ability of HbA1c to predict myocardial fibrosis. METHODS: In total, 80 T2DM patients and 20 age- and sex-matched controls were prospective enrolled and underwent CMR to obtain ECV value and LV function parameters. We divided all patients into a group of HbA1c < 7.0% and a group of HbA1c >/= 7.0%. RESULTS: In the higher HbA1c group the ECV value (all p < 0.001) was higher than both lower HbA1c group (36.23% vs. 32.19%, p < 0.001) and controls (36.23% vs. 29.73%, p < 0.001). HbA1c was positively associated (beta = 0.36, p = 0.004) with ECV, and it was also an independent predictor of myocardial fibrosis (OR = 2.00, P = 0.014). The ROC analysis showed that 7.1% was the optimal cutoff value of HbA1c that predicted the risk of myocardial fibrosis with high diagnostic accuracy (area under the curve = 0.78). CONCLUSION: T1 mapping provided myocardial fibrosis information in T2DM patients. HbA1c is positively correlated with myocardial fibrosis and can be an independently predictor of myocardial fibrosis, which may be helpful for the clinical decision-making of blood glucose control. CI - Copyright (c) 2019 Elsevier B.V. All rights reserved. FAU - Gao, Yue AU - Gao Y AD - Department of Radiology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, West China Second University Hospital, Sichuan University, China; Department of Radiology, West China Hospital, Sichuan University, 37# Guo Xue Xiang, Chengdu, Sichuan 610041, China. FAU - Yang, Zhi-Gang AU - Yang ZG AD - Department of Radiology, West China Hospital, Sichuan University, 37# Guo Xue Xiang, Chengdu, Sichuan 610041, China. FAU - Ren, Yan AU - Ren Y AD - Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, 37# Guo Xue Xiang, Chengdu, Sichuan 610041, China. FAU - Liu, Xi AU - Liu X AD - Department of Radiology, West China Hospital, Sichuan University, 37# Guo Xue Xiang, Chengdu, Sichuan 610041, China. FAU - Jiang, Li AU - Jiang L AD - Department of Radiology, West China Hospital, Sichuan University, 37# Guo Xue Xiang, Chengdu, Sichuan 610041, China. FAU - Xie, Lin-Jun AU - Xie LJ AD - Department of Radiology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, West China Second University Hospital, Sichuan University, China. FAU - Hu, Bi-Yue AU - Hu BY AD - Department of Radiology, West China Hospital, Sichuan University, 37# Guo Xue Xiang, Chengdu, Sichuan 610041, China. FAU - Shen, Meng-Ting AU - Shen MT AD - Department of Radiology, West China Hospital, Sichuan University, 37# Guo Xue Xiang, Chengdu, Sichuan 610041, China. FAU - Xu, Hua-Yan AU - Xu HY AD - Department of Radiology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, West China Second University Hospital, Sichuan University, China. FAU - Li, Zhen-Lin AU - Li ZL AD - Department of Radiology, West China Hospital, Sichuan University, 37# Guo Xue Xiang, Chengdu, Sichuan 610041, China. FAU - Xia, Chun-Chao AU - Xia CC AD - Department of Radiology, West China Hospital, Sichuan University, 37# Guo Xue Xiang, Chengdu, Sichuan 610041, China. FAU - Li, Yu-Ming AU - Li YM AD - Department of Radiology, West China Hospital, Sichuan University, 37# Guo Xue Xiang, Chengdu, Sichuan 610041, China. FAU - Deng, Li-Ling AU - Deng LL AD - Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, 37# Guo Xue Xiang, Chengdu, Sichuan 610041, China. FAU - Deng, Ming-Yan AU - Deng MY AD - Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, 37# Guo Xue Xiang, Chengdu, Sichuan 610041, China. FAU - Zhou, Xiao-Yue AU - Zhou XY AD - MR Collaboration, Siemens Healthcare Ltd., Shanghai, China. FAU - Guo, Ying-Kun AU - Guo YK AD - Department of Radiology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, West China Second University Hospital, Sichuan University, China. Electronic address: gykpanda@163.com. LA - eng PT - Journal Article DEP - 20190304 PL - Ireland TA - Diabetes Res Clin Pract JT - Diabetes research and clinical practice JID - 8508335 RN - 0 (Glycated Hemoglobin A) SB - IM MH - Cardiomyopathies/blood/*diagnosis/diagnostic imaging/etiology MH - Case-Control Studies MH - Diabetes Mellitus, Type 2/*complications/diagnostic imaging MH - Female MH - Fibrosis/blood/*diagnosis/diagnostic imaging/etiology MH - Glycated Hemoglobin/*analysis MH - Humans MH - Magnetic Resonance Imaging, Cine/*methods MH - Male MH - Middle Aged MH - Predictive Value of Tests MH - Prognosis MH - Prospective Studies MH - ROC Curve OTO - NOTNLM OT - Cardiac magnetic resonance OT - Diabetic cardiomyopathy OT - Hyperglycemia OT - Myocardial fibrosis OT - T1 mapping EDAT- 2019/03/08 06:00 MHDA- 2019/07/10 06:00 CRDT- 2019/03/08 06:00 PHST- 2018/08/25 00:00 [received] PHST- 2019/02/10 00:00 [revised] PHST- 2019/03/01 00:00 [accepted] PHST- 2019/03/08 06:00 [pubmed] PHST- 2019/07/10 06:00 [medline] PHST- 2019/03/08 06:00 [entrez] AID - S0168-8227(18)31302-0 [pii] AID - 10.1016/j.diabres.2019.03.004 [doi] PST - ppublish SO - Diabetes Res Clin Pract. 2019 Apr;150:72-80. doi: 10.1016/j.diabres.2019.03.004. Epub 2019 Mar 4.