PMID- 30845182
OWN - NLM
STAT- MEDLINE
DCOM- 20191203
LR  - 20200309
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 14
IP  - 3
DP  - 2019
TI  - Coriandrum sativum seeds extract mitigate progression of diabetic nephropathy in 
      experimental rats via AGEs inhibition.
PG  - e0213147
LID - 10.1371/journal.pone.0213147 [doi]
LID - e0213147
AB  - Inthe present study, we have demonstrated the phytochemical composition of 
      petroleum ether extract of C. sativum (CPE) seeds by using chromatographic, 
      spectroscopic as well spectrometric analysis. CPE was evaluated for its possible 
      role in mitigation of diabetic nephropathy (DN) in Streptozotocin 
      (STZ)-nicotinamide (NAD) induced type 2 diabetes model. Administration of CPE at 
      doses of 100, 200, and 400 mg/kg for 45 days has produced significant attenuation 
      of elevated biochemical parameters including serum glucose, lipid and creatinine 
      levels. CPE has also reserved albuminuria and elevated creatinine clearance in 
      treated diabetic rats. Advanced glycation end products (AGEs) formation in 
      kidneyswas also considerably reduced along with noteworthy increase in level of 
      superoxide dismutase (SOD), glutathione (GSH), and decrease in lipid peroxidation 
      in terms of thiobarbituric acid reactive species (TBARS). Molecular docking 
      studies were also employed to reveal out the possible mechanism. In conclusion, 
      using STZ-NAD model, we have successfully predicted that by assets of bioactive 
      constituents CPE might inhibit the progression of DN. C. sativum may act as 
      potential adjuvant for antidiabetic therapy and needs to be investigated further.
FAU - Kajal, Anu
AU  - Kajal A
AD  - M. M College of Pharmacy, M. M (Deemed to be University), Mullana, Ambala, 
      Haryana, India.
FAU - Singh, Randhir
AU  - Singh R
AUID- ORCID: 0000-0003-0183-0797
AD  - M. M College of Pharmacy, M. M (Deemed to be University), Mullana, Ambala, 
      Haryana, India.
LA  - eng
PT  - Journal Article
DEP - 20190307
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Blood Glucose)
RN  - 0 (Glycation End Products, Advanced)
RN  - 0 (Lipids)
RN  - 0 (Plant Extracts)
RN  - 0 (Terpenes)
RN  - AYI8EX34EU (Creatinine)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - GAN16C9B8O (Glutathione)
SB  - IM
MH  - Animals
MH  - Binding Sites
MH  - Blood Glucose/analysis
MH  - Coriandrum/*chemistry/metabolism
MH  - Creatinine/blood
MH  - Diabetes Mellitus, Experimental/chemically induced/complications
MH  - Diabetic Nephropathies/drug therapy/*pathology
MH  - Gas Chromatography-Mass Spectrometry
MH  - Glutathione/metabolism
MH  - Glycation End Products, Advanced/antagonists & inhibitors/*metabolism
MH  - Lipid Peroxidation/drug effects
MH  - Lipids/blood
MH  - Male
MH  - Molecular Docking Simulation
MH  - Plant Extracts/*chemistry/pharmacology/therapeutic use
MH  - Rats
MH  - Rats, Wistar
MH  - Seeds/chemistry/metabolism
MH  - Superoxide Dismutase/metabolism
MH  - Terpenes/analysis/pharmacology/therapeutic use
PMC - PMC6405108
COIS- The authors have declared that no competing interests exist.
EDAT- 2019/03/08 06:00
MHDA- 2019/12/04 06:00
PMCR- 2019/03/07
CRDT- 2019/03/08 06:00
PHST- 2018/10/29 00:00 [received]
PHST- 2019/02/17 00:00 [accepted]
PHST- 2019/03/08 06:00 [entrez]
PHST- 2019/03/08 06:00 [pubmed]
PHST- 2019/12/04 06:00 [medline]
PHST- 2019/03/07 00:00 [pmc-release]
AID - PONE-D-18-31150 [pii]
AID - 10.1371/journal.pone.0213147 [doi]
PST - epublish
SO  - PLoS One. 2019 Mar 7;14(3):e0213147. doi: 10.1371/journal.pone.0213147. 
      eCollection 2019.