PMID- 30845291
OWN - NLM
STAT- MEDLINE
DCOM- 20190408
LR  - 20190408
IS  - 2066-8279 (Electronic)
IS  - 1220-0522 (Linking)
VI  - 59
IP  - 4
DP  - 2018
TI  - Evaluation of antioxidant capacity and clinical assessment of patients with 
      chronic periodontitis treated with non-surgical periodontal therapy and 
      adjunctive systemic antibiotherapy.
PG  - 1107-1113
AB  - This study aims to evaluate the oxidative stress changes in patients with chronic 
      periodontitis (CP) undergoing non-surgical periodontal therapy alone, compared 
      with non-surgical periodontal therapy with adjunctive systemic antibiotic 
      therapy. Sixteen patients with CP, randomly assigned into two equal groups, were 
      treated either with scaling and root planing (SRP) + Amoxicillin + Metronidazole, 
      each 500 mg, three times daily, for seven days (test group), or with SRP + 
      placebo for seven days (control group). Venous blood and unstimulated saliva 
      samples were collected. Non-surgical periodontal therapy was performed 
      simultaneously with antibiotics administration. Oxidative stress balance was 
      evaluated by measuring derivatives of reactive oxygen metabolites (d-ROMs) and 
      the biological antioxidant potential (BAP) in plasma. After the microscopic 
      evaluation of the pathological aspect of the epithelial cells (ECs), their 
      number, viability and the presence of C-reactive protein (CRP) were reevaluated 
      from saliva at seven days, while reduced glutathione (GSH) level, d-ROMs and BAP 
      at three months. Wilcoxon and Kruskal-Wallis rank-tests were used for statistics. 
      At three months, statistical significant reductions of mean periodontal pocket 
      depth (PPD) and clinical attachment level (CAL) gains (both p=0.01) were found in 
      test group. Full-mouth plaque score (FMPS) decreased statistically significant in 
      control group (p=0.02), d-ROMs decreased statistically significant in test group 
      (mean difference 116.24+/-107.6 U CARR, p=0.01). Mean GSH, BAP level, number of 
      ECs, their viability and CRP were statistically non-significant. In test group 
      patients, oxidative stress status changed from a very high level to a medium one, 
      suggesting that adjunctive use of antibiotics could have contributed to the 
      reduction of reactive oxygen metabolites, along with significant clinical 
      improvements.
FAU - Boia, Simina
AU  - Boia S
AD  - Department of Endodontics, Faculty of Dental Medicine, "Victor Babes" University 
      of Medicine and Pharmacy, Timisoara, Romania; boarium@yahoo.com.
FAU - Stratul, Stefan Ioan
AU  - Stratul SI
FAU - Boariu, Marius
AU  - Boariu M
FAU - Ursoniu, Sorin
AU  - Ursoniu S
FAU - Gotia, Smaranda Laura
AU  - Gotia SL
FAU - Boia, Eugen Radu
AU  - Boia ER
FAU - Borza, Claudia
AU  - Borza C
LA  - eng
PT  - Journal Article
PL  - Romania
TA  - Rom J Morphol Embryol
JT  - Romanian journal of morphology and embryology = Revue roumaine de morphologie et 
      embryologie
JID - 9112454
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Antioxidants)
RN  - 0 (Reactive Oxygen Species)
SB  - IM
MH  - Adult
MH  - Anti-Bacterial Agents/*therapeutic use
MH  - Antioxidants/*therapeutic use
MH  - Chronic Periodontitis/complications/*drug therapy/*pathology
MH  - Dental Plaque/complications/drug therapy
MH  - Dental Scaling
MH  - Humans
MH  - Middle Aged
MH  - Periodontal Pocket/congenital/drug therapy
MH  - Reactive Oxygen Species/metabolism
MH  - Root Planing
MH  - Saliva/metabolism
EDAT- 2018/01/01 00:00
MHDA- 2019/04/09 06:00
CRDT- 2019/03/08 06:00
PHST- 2019/03/08 06:00 [entrez]
PHST- 2018/01/01 00:00 [pubmed]
PHST- 2019/04/09 06:00 [medline]
AID - 59041811071113 [pii]
PST - ppublish
SO  - Rom J Morphol Embryol. 2018;59(4):1107-1113.