PMID- 30845688
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 2076-328X (Print)
IS  - 2076-328X (Electronic)
IS  - 2076-328X (Linking)
VI  - 9
IP  - 3
DP  - 2019 Mar 6
TI  - Effects of Memantine in a Mouse Model of Postoperative Cognitive Dysfunction.
LID - 10.3390/bs9030024 [doi]
LID - 24
AB  - Persistent impairment in cognitive functioning postoperatively is reported by 
      clinical and animal studies, and is labeled as postoperative cognitive 
      dysfunction (POCD). Evidence points to an exaggerated neuroinflammatory response 
      resulting from peripheral systemic inflammation after surgery, with subsequent 
      cytokine-induced glutamatergic excitotoxicity and synaptic impairment. These 
      immunological changes, among many others, are also observed in Alzheimer's 
      disease. Memantine is an N-methyl-D-aspartate receptor (NMDAR) antagonist 
      commonly used to treat Alzheimer's disease. Surprisingly, little research exists 
      on the role of memantine in preventing POCD. The purpose of this study is to 
      investigate the effects of memantine on a spectrum of cognitive functions 
      postoperatively. Mice were divided into 3 groups and each received treatment for 
      4 weeks. Placebo groups received a placebo then underwent either a sham procedure 
      or a laparotomy procedure. The memantine group received memantine hydrochloride 
      then underwent a laparotomy procedure. Cognitive tests were performed on 
      postoperative days (POD) 1 and 7. Compared to sham-operated mice, placebo groups 
      that underwent a laparotomy procedure showed impaired memory in the Morris water 
      maze test, higher anxiety-like behavior in the open field and the elevated plus 
      maze tests, increased depression-like behavior in the tail suspension test, and 
      lack of preference for social novelty in the three-chamber test. On the other 
      hand, memantine-treated mice that underwent a laparotomy procedure showed 
      enhanced memory on POD7, improved depression-like behavior on POD1 and POD7, 
      enhanced preference for social novelty on POD1, and no improvement in 
      anxiety-like behavior. These findings suggest a potential protective effect of 
      memantine in mice postoperatively on memory, depression-like behavior, and 
      preference for social novelty.
FAU - Almahozi, Ahmad
AU  - Almahozi A
AUID- ORCID: 0000-0002-0391-6124
AD  - Physiology Department, College of Medicine and Medical Sciences, Arabian Gulf 
      University, P.O. Box 26671, Manama 1111, Bahrain. a.mahozi@gmail.com.
FAU - Radhi, Mohamed
AU  - Radhi M
AD  - Physiology Department, College of Medicine and Medical Sciences, Arabian Gulf 
      University, P.O. Box 26671, Manama 1111, Bahrain. mohamed@radhi.co.
FAU - Alzayer, Suja
AU  - Alzayer S
AD  - Physiology Department, College of Medicine and Medical Sciences, Arabian Gulf 
      University, P.O. Box 26671, Manama 1111, Bahrain. suja.alzayer@gmail.com.
FAU - Kamal, Amer
AU  - Kamal A
AUID- ORCID: 0000-0002-0545-0815
AD  - Physiology Department, College of Medicine and Medical Sciences, Arabian Gulf 
      University, P.O. Box 26671, Manama 1111, Bahrain. amerha@agu.edu.bh.
LA  - eng
PT  - Journal Article
DEP - 20190306
PL  - Switzerland
TA  - Behav Sci (Basel)
JT  - Behavioral sciences (Basel, Switzerland)
JID - 101576826
PMC - PMC6466583
OTO - NOTNLM
OT  - Alzehimer's
OT  - POCD
OT  - memantine
OT  - mice
OT  - neuroinflammation
OT  - postoperative cognitive dysfunction
COIS- The authors declare no conflict of interest.
EDAT- 2019/03/09 06:00
MHDA- 2019/03/09 06:01
PMCR- 2019/03/01
CRDT- 2019/03/09 06:00
PHST- 2018/12/15 00:00 [received]
PHST- 2019/02/18 00:00 [revised]
PHST- 2019/02/27 00:00 [accepted]
PHST- 2019/03/09 06:00 [entrez]
PHST- 2019/03/09 06:00 [pubmed]
PHST- 2019/03/09 06:01 [medline]
PHST- 2019/03/01 00:00 [pmc-release]
AID - bs9030024 [pii]
AID - behavsci-09-00024 [pii]
AID - 10.3390/bs9030024 [doi]
PST - epublish
SO  - Behav Sci (Basel). 2019 Mar 6;9(3):24. doi: 10.3390/bs9030024.