PMID- 30847698
OWN - NLM
STAT- MEDLINE
DCOM- 20191206
LR  - 20200501
IS  - 1573-7330 (Electronic)
IS  - 1058-0468 (Print)
IS  - 1058-0468 (Linking)
VI  - 36
IP  - 5
DP  - 2019 May
TI  - Understanding the role of killer cell immunoglobulin-like receptors in pregnancy 
      complications.
PG  - 827-835
LID - 10.1007/s10815-019-01426-9 [doi]
AB  - Pregnancy is a unique immunological situation in which a fetus-bearing paternal 
      histocompatibility antigens can survive in a maternal environment without 
      apparent rejection. To face this challenge, cells of the uterine immune system 
      show characteristic changes in absolute number and composition during pregnancy. 
      Particularly relevant to this process are uterine natural killer (uNK) cells and 
      their cell surface receptors, killer immunoglobulin-like receptors (KIRs). The 
      main purpose of this review is to outline the current body of knowledge on the 
      involvement of KIRs in the complications of pregnancy. Implantation depends on 
      the invasion of embryonic trophoblast cells into maternal uterine tissue and 
      remodeling of the uterine spiral arterioles, which is essential for placental 
      perfusion and successful pregnancy. The proper interaction between maternal KIRs 
      and their ligands human leukocyte antigen (HLA) class I molecules, expressed by 
      the extravillous trophoblast cells, is crucial in this process. KIRs are a 
      complex family that includes both activator and inhibitory receptors. The 
      activation profile is genetically determined in each individual and leads to 
      diverse levels of functionality for NK and T cells on engagement with specific 
      HLA class I molecules. An association between different KIR alleles and HLA 
      molecules has been reported in pregnancy complications, supporting the idea of a 
      relevant role of these receptors in successful pregnancy.
FAU - Diaz-Pena, R
AU  - Diaz-Pena R
AUID- ORCID: 0000-0002-0114-2292
AD  - Liquid Biopsy Analysis Unit, Health Research Institute of Santiago (IDIS), 
      Complexo Hospitalario Universitario de Santiago de Compostela (SERGAS), Santiago 
      de Compostela, Spain.
AD  - Facultad de Ciencias de la Salud, Universidad Autonoma de Chile, Talca, Chile.
FAU - de Los Santos, M J
AU  - de Los Santos MJ
AD  - IVI-RMA, Fundacion IVI; INCLIVA, IIS La Fe, Valencia University, Valencia, Spain.
FAU - Lucia, Alejandro
AU  - Lucia A
AD  - Faculty of Sport Sciences and Instituto de Investigacion Hospital 12 de Octubre, 
      Universidad Europea de Madrid, Madrid, Spain.
FAU - Castro-Santos, P
AU  - Castro-Santos P
AD  - Inmunologia, Centro de Investigaciones Biomedicas (CINBIO), Universidade de Vigo, 
      Vigo, Spain. patrcastro@uvigo.es.
LA  - eng
GR  - No number/Centro Singular de Investigacion de Galicia/
PT  - Journal Article
PT  - Review
DEP - 20190307
PL  - Netherlands
TA  - J Assist Reprod Genet
JT  - Journal of assisted reproduction and genetics
JID - 9206495
RN  - 0 (HLA Antigens)
RN  - 0 (Receptors, KIR)
SB  - IM
MH  - Embryo Implantation/*immunology
MH  - Female
MH  - HLA Antigens/*immunology/metabolism
MH  - Humans
MH  - Killer Cells, Natural/*immunology/metabolism
MH  - Placentation/*immunology
MH  - Pregnancy
MH  - Pregnancy Complications/*immunology/*pathology
MH  - Receptors, KIR/*immunology/metabolism
PMC - PMC6541663
OTO - NOTNLM
OT  - Extravillous trophoblast
OT  - HLA
OT  - KIR
OT  - Recurrent miscarriage
OT  - Uterine natural killer
EDAT- 2019/03/09 06:00
MHDA- 2019/12/18 06:00
PMCR- 2020/05/01
CRDT- 2019/03/09 06:00
PHST- 2018/11/06 00:00 [received]
PHST- 2019/02/20 00:00 [accepted]
PHST- 2019/03/09 06:00 [pubmed]
PHST- 2019/12/18 06:00 [medline]
PHST- 2019/03/09 06:00 [entrez]
PHST- 2020/05/01 00:00 [pmc-release]
AID - 10.1007/s10815-019-01426-9 [pii]
AID - 1426 [pii]
AID - 10.1007/s10815-019-01426-9 [doi]
PST - ppublish
SO  - J Assist Reprod Genet. 2019 May;36(5):827-835. doi: 10.1007/s10815-019-01426-9. 
      Epub 2019 Mar 7.