PMID- 30848395
OWN - NLM
STAT- MEDLINE
DCOM- 20190503
LR  - 20200225
IS  - 1613-2246 (Electronic)
IS  - 0021-5155 (Linking)
VI  - 63
IP  - 3
DP  - 2019 May
TI  - Efficacy of N95 amplitude of pattern electroretinogram measured from baseline to 
      N95 trough in the traumatic optic neuropathy.
PG  - 284-288
LID - 10.1007/s10384-019-00664-9 [doi]
AB  - PURPOSE: To investigate the utility of selected pattern electroretinogram (PERG) 
      parameters-including N95 amplitude and N95/P50 ratio, and a BL-N95 amplitude-in 
      the analysis of visual function(s) and for predicting changes in retinal ganglion 
      cell structures in traumatic optic neuropathy. STUDY DESIGN: A retrospective, 
      observational case series performed at a single center. METHODS: Forty-four eyes 
      from 36 patients diagnosed with optic neuropathy were included. A BL-N95 
      amplitude was defined as the amplitude measured from baseline to the trough of 
      N95. PERG and pattern visual evoked potential (pVEP) measures were acquired 
      within 1 week after onset of optic neuropathies. To compare functional and 
      anatomical changes, mean temporal peripapillary retinal nerve fiber layer (pRNFL) 
      and average and minimum ganglion cell-inner plexiform layer (GC-IPL) thicknesses 
      were measured using optical coherence tomography. RESULTS: Thirty-six patients 
      (20 men, 16 women; mean age 37.5 +/- 17.6 years) were evaluated. The BL-N95 
      amplitude was significantly smaller than the N95 amplitude (1.01 +/- 0.56 muV and 
      2.45 +/- 1.02 muV, respectively; p  < 0.0001). Both the N95 (r  = - 0.38, p  
      = 0.010) and BL-N95 r  = - 0.32, p  = 0.029) amplitudes were significantly 
      correlated with visual acuity. Although P100 latency was not correlated with all 
      PERG parameters, the N95 (r  = 0.32, p  = 0.032) and BL-N95 (r  = 0.41, p  
      = 0.005) amplitudes demonstrated a positive correlation with P100 amplitude in 
      pVEP. PERG parameters, including the N95 and BL-N95 amplitudes, and N95/P50 
      ratio, were not correlated with pRNFL thickness in optical coherence tomography. 
      Only the BL-N95 amplitude demonstrated a significant correlation with GC-IPL. 
      CONCLUSION: The BL-N95 amplitude-measured from baseline to the trough of N95-was 
      valuable in the analysis of visual function(s) and for predicting changes in 
      retinal ganglion cell structures in traumatic optic neuropathy.
FAU - Kim, Kun Hae
AU  - Kim KH
AD  - Department of Ophthalmology, Kim's Eye Hospital, Youngshin-ro 136, 
      Youngdeungpo-gu, Seoul, 07301, Korea.
FAU - Kim, Ungsoo Samuel
AU  - Kim US
AD  - Department of Ophthalmology, Kim's Eye Hospital, Youngshin-ro 136, 
      Youngdeungpo-gu, Seoul, 07301, Korea. ungsookim@kimeye.com.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20190308
PL  - Japan
TA  - Jpn J Ophthalmol
JT  - Japanese journal of ophthalmology
JID - 0044652
SB  - IM
MH  - Adult
MH  - Electroretinography/*methods
MH  - Evoked Potentials, Visual/*physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Nerve Fibers/pathology
MH  - Optic Nerve Diseases/*diagnosis/etiology/physiopathology
MH  - Optic Nerve Injuries/*complications/diagnosis/physiopathology
MH  - Reproducibility of Results
MH  - Retinal Ganglion Cells/*pathology
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence
MH  - *Visual Acuity
MH  - Visual Field Tests
MH  - *Visual Fields
OTO - NOTNLM
OT  - Electrophysiology
OT  - Optic neuropathy
OT  - Pattern electroretinogram
OT  - Pattern visual evoked potential
EDAT- 2019/03/09 06:00
MHDA- 2019/05/06 06:00
CRDT- 2019/03/09 06:00
PHST- 2018/06/20 00:00 [received]
PHST- 2019/01/27 00:00 [accepted]
PHST- 2019/03/09 06:00 [pubmed]
PHST- 2019/05/06 06:00 [medline]
PHST- 2019/03/09 06:00 [entrez]
AID - 10.1007/s10384-019-00664-9 [pii]
AID - 10.1007/s10384-019-00664-9 [doi]
PST - ppublish
SO  - Jpn J Ophthalmol. 2019 May;63(3):284-288. doi: 10.1007/s10384-019-00664-9. Epub 
      2019 Mar 8.