PMID- 30848753
OWN - NLM
STAT- MEDLINE
DCOM- 20190313
LR  - 20190313
IS  - 0717-6163 (Electronic)
IS  - 0034-9887 (Linking)
VI  - 146
IP  - 12
DP  - 2018 Dec
TI  - [Cerebral cryptococcosis and immune reconstitution inflammatory syndrome. Case 
      report].
PG  - 1481-1485
LID - S0034-98872018001201481 [pii]
LID - 10.4067/s0034-98872018001201481 [doi]
AB  - We report a 45-year-old male with AIDS who had a Cryptococcus neoformans central 
      nervous system infection. He was treated with amphotericin B deoxycholate 
      subsequently changed to voriconazole due to systemic toxicity of the former. 
      Plasma levels of voriconazole were insufficient with a standard dose (0.7 mug/mL), 
      therefore, the dose was increased thereafter to reach appropriate levels (4.5 
      mug/mL). Anti-retroviral therapy was started five weeks after voriconazole 
      initiation with non-interacting drugs and he was discharged after a favorable 
      evolution. He was re-admitted three months later due to seizures; a brain 
      magnetic resonance showed new sub-cortical nodules. After excluding alternative 
      causes and demonstrating fungal eradication, an immune reconstitution 
      inflammatory syndrome (IRIS) event was suspected and treated with a short course 
      of steroids. His evolution was satisfactory.
FAU - Tellez R, Maria
AU  - Tellez R M
AD  - Universidad Austral de Chile, Valdivia, Chile.
FAU - Salgueiro C, Catalina
AU  - Salgueiro C C
AD  - Universidad Austral de Chile, Valdivia, Chile.
FAU - Leiva Hernandez, Marcelo
AU  - Leiva Hernandez M
AD  - Subdepartamento de Neurologia, Hospital Base de Valdivia, Valdivia, Chile.
FAU - Fica, Alberto
AU  - Fica A
AD  - Subdepartamento de Medicina, Hospital Base de Valdivia, Valdivia, Chile.
LA  - spa
PT  - Case Reports
PT  - Journal Article
TT  - Criptococosis cerebral, voriconazol, niveles plasmaticos y sindrome de 
      reconstitucion inmune. Reporte de un caso.
PL  - Chile
TA  - Rev Med Chil
JT  - Revista medica de Chile
JID - 0404312
RN  - 0 (Antifungal Agents)
RN  - 0 (Drug Combinations)
RN  - 005990WHZZ (Deoxycholic Acid)
RN  - 7XU7A7DROE (Amphotericin B)
RN  - 87687-70-5 (amphotericin B, deoxycholate drug combination)
RN  - JFU09I87TR (Voriconazole)
SB  - IM
MH  - AIDS-Related Opportunistic Infections/diagnostic imaging/*drug therapy
MH  - Amphotericin B/administration & dosage/*adverse effects
MH  - Antifungal Agents/administration & dosage/*adverse effects
MH  - Deoxycholic Acid/administration & dosage/*adverse effects
MH  - Drug Combinations
MH  - Humans
MH  - Immune Reconstitution Inflammatory Syndrome/*chemically induced
MH  - Male
MH  - Meningitis, Cryptococcal/diagnostic imaging/*drug therapy
MH  - Middle Aged
MH  - Voriconazole/*administration & dosage
EDAT- 2019/03/09 06:00
MHDA- 2019/03/14 06:00
CRDT- 2019/03/09 06:00
PHST- 2018/07/31 00:00 [received]
PHST- 2018/11/07 00:00 [accepted]
PHST- 2019/03/09 06:00 [entrez]
PHST- 2019/03/09 06:00 [pubmed]
PHST- 2019/03/14 06:00 [medline]
AID - S0034-98872018001201481 [pii]
AID - 10.4067/s0034-98872018001201481 [doi]
PST - ppublish
SO  - Rev Med Chil. 2018 Dec;146(12):1481-1485. doi: 10.4067/s0034-98872018001201481.