PMID- 30849412
OWN - NLM
STAT- MEDLINE
DCOM- 20200617
LR  - 20200617
IS  - 1872-9452 (Electronic)
IS  - 0098-2997 (Linking)
VI  - 66
DP  - 2019 Apr
TI  - Altered foetoplacental vascular endothelial signalling to insulin in diabesity.
PG  - 40-48
LID - S0098-2997(18)30081-5 [pii]
LID - 10.1016/j.mam.2019.02.003 [doi]
AB  - Obesity and type 2 diabetes mellitus (T2DM) are diseases associated with 
      hypertension and metabolic alterations. A significant group of patients present 
      both obesity and T2DM, a condition defined as diabesity. One of the metabolic 
      features in these conditions is the clinical presentation of insulin resistance. 
      Several tissues, including the liver, skeletal muscle, and vasculature, and 
      patients with T2DM, gestational diabetes, and obesity show insulin resistance. 
      The vascular effect of insulin, including vasodilation, is mainly mediated by the 
      generation of nitric oxide. Several mechanisms are proposed to elucidate the 
      origin of insulin resistance; nevertheless, a common finding is the endothelial 
      dysfunction in these diseases. Endothelial cells from subjects with obesity show 
      reduced nitric oxide synthesis, an effect that is unaltered by insulin. 
      Individuals with T2DM show a misbalance between the synthesis, release, and 
      biological actions of vasodilators and vasoconstrictors such as nitric oxide and 
      endothelin-1. However, whether these mechanisms are involved in the vascular 
      alterations seen in patients with diabesity is unclear. In this review, we 
      discussed the modifications on insulin signalling, insulin resistance in obesity 
      and T2DM, and the reported changes in signalling pathways in diabesity.
CI  - Copyright (c) 2019. Published by Elsevier Ltd.
FAU - Pardo, Fabian
AU  - Pardo F
AD  - Cellular and Molecular Physiology Laboratory, Department of Obstetrics, Division 
      of Obstetrics and Gynaecology, School of Medicine, Faculty of Medicine, 
      Pontificia Universidad Catolica de Chile, Santiago, 8330024, Chile; Metabolic 
      Diseases Research Laboratory, Interdisciplinary Center of Territorial Health 
      Research (CIISTe), San Felipe Campus, School of Medicine, Faculty of Medicine, 
      Universidad de Valparaiso, San Felipe, 2172972, Chile. Electronic address: 
      fabian.pardo@uv.cl.
FAU - Subiabre, Mario
AU  - Subiabre M
AD  - Cellular and Molecular Physiology Laboratory, Department of Obstetrics, Division 
      of Obstetrics and Gynaecology, School of Medicine, Faculty of Medicine, 
      Pontificia Universidad Catolica de Chile, Santiago, 8330024, Chile.
FAU - Fuentes, Gonzalo
AU  - Fuentes G
AD  - Cellular and Molecular Physiology Laboratory, Department of Obstetrics, Division 
      of Obstetrics and Gynaecology, School of Medicine, Faculty of Medicine, 
      Pontificia Universidad Catolica de Chile, Santiago, 8330024, Chile; Cell 
      Physiology Laboratory, Biomedical Department, Faculty of Health Sciences, 
      Universidad de Antofagasta, Antofagasta, 1270300, Chile.
FAU - Toledo, Fernando
AU  - Toledo F
AD  - Cellular and Molecular Physiology Laboratory, Department of Obstetrics, Division 
      of Obstetrics and Gynaecology, School of Medicine, Faculty of Medicine, 
      Pontificia Universidad Catolica de Chile, Santiago, 8330024, Chile; Department of 
      Basic Sciences, Faculty of Sciences, Universidad del Bio-Bio, Chillan, 3780000, 
      Chile.
FAU - Silva, Luis
AU  - Silva L
AD  - Cellular and Molecular Physiology Laboratory, Department of Obstetrics, Division 
      of Obstetrics and Gynaecology, School of Medicine, Faculty of Medicine, 
      Pontificia Universidad Catolica de Chile, Santiago, 8330024, Chile; 
      Immunoendocrinology, Division of Medical Biology, Department of Pathology and 
      Medical Biology, University of Groningen, University Medical Centre Groningen 
      (UMCG), Groningen, 9700 RB, the Netherlands.
FAU - Villalobos-Labra, Roberto
AU  - Villalobos-Labra R
AD  - Cellular and Molecular Physiology Laboratory, Department of Obstetrics, Division 
      of Obstetrics and Gynaecology, School of Medicine, Faculty of Medicine, 
      Pontificia Universidad Catolica de Chile, Santiago, 8330024, Chile.
FAU - Sobrevia, Luis
AU  - Sobrevia L
AD  - Cellular and Molecular Physiology Laboratory, Department of Obstetrics, Division 
      of Obstetrics and Gynaecology, School of Medicine, Faculty of Medicine, 
      Pontificia Universidad Catolica de Chile, Santiago, 8330024, Chile; Department of 
      Physiology, Faculty of Pharmacy, Universidad de Sevilla, Seville, E-41012, Spain; 
      University of Queensland Centre for Clinical Research (UQCCR), Faculty of 
      Medicine and Biomedical Sciences, University of Queensland, Herston, QLD 4029, 
      Queensland, Australia. Electronic address: lsobrevia@uc.cl.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20190308
PL  - England
TA  - Mol Aspects Med
JT  - Molecular aspects of medicine
JID - 7603128
RN  - 0 (Insulin)
RN  - 31C4KY9ESH (Nitric Oxide)
SB  - IM
MH  - Diabetes Mellitus, Type 2/*metabolism
MH  - Diabetes, Gestational/*metabolism
MH  - Endothelium, Vascular/metabolism
MH  - Female
MH  - Humans
MH  - Insulin/*metabolism
MH  - Insulin Resistance
MH  - Nitric Oxide/metabolism
MH  - Obesity/*metabolism
MH  - Placenta/*blood supply/metabolism
MH  - Pregnancy
MH  - Signal Transduction
OTO - NOTNLM
OT  - Diabesity
OT  - Diabetes
OT  - Endothelium
OT  - Insulin resistance
OT  - Obesity
OT  - Vascular
EDAT- 2019/03/09 06:00
MHDA- 2020/06/18 06:00
CRDT- 2019/03/09 06:00
PHST- 2018/08/07 00:00 [received]
PHST- 2019/02/19 00:00 [revised]
PHST- 2019/02/28 00:00 [accepted]
PHST- 2019/03/09 06:00 [pubmed]
PHST- 2020/06/18 06:00 [medline]
PHST- 2019/03/09 06:00 [entrez]
AID - S0098-2997(18)30081-5 [pii]
AID - 10.1016/j.mam.2019.02.003 [doi]
PST - ppublish
SO  - Mol Aspects Med. 2019 Apr;66:40-48. doi: 10.1016/j.mam.2019.02.003. Epub 2019 Mar 
      8.