PMID- 30849456
OWN - NLM
STAT- MEDLINE
DCOM- 20190624
LR  - 20190624
IS  - 1879-3150 (Electronic)
IS  - 0041-0101 (Linking)
VI  - 162
DP  - 2019 Apr 15
TI  - Assessment of the efficacy of a grape seed waste in counteracting the changes 
      induced by aflatoxin B1 contaminated diet on performance, plasma, liver and 
      intestinal tissues of pigs after weaning.
PG  - 24-31
LID - S0041-0101(19)30061-3 [pii]
LID - 10.1016/j.toxicon.2019.02.020 [doi]
AB  - The aim of this study was to investigate the potential of a grape seed byproduct 
      to mitigate the harmful damage produced by aflatoxin B1 (AFB1) at systemic level 
      in plasma and liver as well as at local level in the gastrointestinal tract in 
      weaned piglets. Twenty four crossbred pigs (TOPIG) were randomly assigned to one 
      of four experimental diets: 1)- control diet (normal compound feed for starter 
      piglets without mycotoxin), 2)- AFB1 diet (compound feed contaminated with 
      320 ppb pure AFB1), 3)- GS diet (compound feed including 8% of grape seed meal), 
      4)- AFB1+GS diet (compound feed containing 8% of grape seed meal contaminated 
      with 320 ppb AFB1) for 30 days. The results showed that pigs fed AFB1 diet had 
      altered performance (-25.1%), increased the thiobarbituric substances (TBARS) 
      concentration wile reduced total antioxidant capacity and activity of antioxidant 
      enzymes (CAT, SOD and GPx) in plasma and organs. AFB1 produced a dual effect on 
      inflammatory response by increasing the level of pro-inflammatory cytokines in 
      liver and colon and decreasing these cytokines in duodenum. The inclusion of 
      grape seed in the diet of AFB1 intoxicated pigs enhanced the antioxidant enzymes 
      activity, decreased the pro-inflammatory cytokines and TBARS level and 
      ameliorated the growth performance of AFB1-treated animals. These findings 
      suggest that grape waste is a promising feed source in counteracting the harmful 
      effect of aflatoxin B1.
CI  - Copyright (c) 2019. Published by Elsevier Ltd.
FAU - Taranu, Ionelia
AU  - Taranu I
AD  - Laboratory of Animal Biology, National Institute for Research and Development for 
      Biology and Animal Nutrition, Calea Bucuresti No. 1, Balotesti, Ilfov, 077015, 
      Romania. Electronic address: ionelia.taranu@ibna.ro.
FAU - Marin, Daniela Eliza
AU  - Marin DE
AD  - Laboratory of Animal Biology, National Institute for Research and Development for 
      Biology and Animal Nutrition, Calea Bucuresti No. 1, Balotesti, Ilfov, 077015, 
      Romania.
FAU - Palade, Mihai
AU  - Palade M
AD  - Laboratory of Animal Biology, National Institute for Research and Development for 
      Biology and Animal Nutrition, Calea Bucuresti No. 1, Balotesti, Ilfov, 077015, 
      Romania.
FAU - Pistol, Gina Cecilia
AU  - Pistol GC
AD  - Laboratory of Animal Biology, National Institute for Research and Development for 
      Biology and Animal Nutrition, Calea Bucuresti No. 1, Balotesti, Ilfov, 077015, 
      Romania.
FAU - Chedea, Veronica Sanda
AU  - Chedea VS
AD  - Laboratory of Animal Biology, National Institute for Research and Development for 
      Biology and Animal Nutrition, Calea Bucuresti No. 1, Balotesti, Ilfov, 077015, 
      Romania.
FAU - Gras, Mihail Alexandru
AU  - Gras MA
AD  - Laboratory of Animal Biology, National Institute for Research and Development for 
      Biology and Animal Nutrition, Calea Bucuresti No. 1, Balotesti, Ilfov, 077015, 
      Romania.
FAU - Rotar, Catalin
AU  - Rotar C
AD  - Laboratory of Animal Biology, National Institute for Research and Development for 
      Biology and Animal Nutrition, Calea Bucuresti No. 1, Balotesti, Ilfov, 077015, 
      Romania.
LA  - eng
PT  - Journal Article
DEP - 20190305
PL  - England
TA  - Toxicon
JT  - Toxicon : official journal of the International Society on Toxinology
JID - 1307333
RN  - 0 (Antioxidants)
RN  - 0 (Cytokines)
RN  - 0 (Thiobarbituric Acid Reactive Substances)
RN  - 9N2N2Y55MH (Aflatoxin B1)
SB  - IM
MH  - Aflatoxin B1/*toxicity
MH  - Animal Feed/analysis
MH  - Animal Nutritional Physiological Phenomena
MH  - Animals
MH  - Antioxidants/metabolism
MH  - Cytokines/metabolism
MH  - Diet/*veterinary
MH  - Food Contamination/prevention & control
MH  - Seeds
MH  - Sus scrofa/blood/*growth & development
MH  - Thiobarbituric Acid Reactive Substances/metabolism
MH  - *Vitis
OTO - NOTNLM
OT  - AFB1
OT  - Antioxidative response
OT  - Grape seed waste
OT  - Inflammation
OT  - Pig
EDAT- 2019/03/09 06:00
MHDA- 2019/06/25 06:00
CRDT- 2019/03/09 06:00
PHST- 2018/11/17 00:00 [received]
PHST- 2019/02/26 00:00 [revised]
PHST- 2019/02/28 00:00 [accepted]
PHST- 2019/03/09 06:00 [pubmed]
PHST- 2019/06/25 06:00 [medline]
PHST- 2019/03/09 06:00 [entrez]
AID - S0041-0101(19)30061-3 [pii]
AID - 10.1016/j.toxicon.2019.02.020 [doi]
PST - ppublish
SO  - Toxicon. 2019 Apr 15;162:24-31. doi: 10.1016/j.toxicon.2019.02.020. Epub 2019 Mar 
      5.