PMID- 3085111
OWN - NLM
STAT- MEDLINE
DCOM- 19860523
LR  - 20131121
IS  - 0176-3679 (Print)
IS  - 0176-3679 (Linking)
VI  - 19
IP  - 2
DP  - 1986 Mar
TI  - Erythrocyte lithium transport during lithium treatment in patients with affective 
      disorders.
PG  - 63-7
AB  - Erythrocyte lithium transport mechanisms--lithium-sodium countertransport (LSC), 
      lithium-potassium cotransport (LPC) and passive lithium efflux (PLE)--were 
      measured in 46 patients with bipolar affective disorder on prophylactic lithium 
      therapy and in 20 healthy control subjects. Maximal velocity of LSC measured at 
      saturating intracellular lithium concentration was lower in the patients than in 
      the controls; this may concur with previous reports on possible links between 
      impaired activity of LSC and bipolar affective illness. When measured at 
      therapeutic lithium concentration, LSC was 4 times lower and Km for LSC was 5 
      times higher in lithium-treated affective patients than in control subjects. The 
      in vivo erythrocyte:plasma lithium ratio was inversely correlated with LSC in 
      lithium-treated patients; higher ratios were found in females than in males. No 
      differences were found between affective patients and control subjects in other 
      erythrocyte lithium transport measurements. The values for lithium transport were 
      not related to age, duration of lithium therapy, concomitant neuroleptic 
      treatment, hypertension or obesity. Lower activity of LSC was found in patients 
      with lithium-induced thyroid enlargement than in the other patients. The results 
      obtained are discussed in the light of contemporary findings concerning 
      erythrocyte lithium transport mechanisms in affective disorders and other 
      conditions.
FAU - Zaremba, D
AU  - Zaremba D
FAU - Rybakowski, J
AU  - Rybakowski J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Pharmacopsychiatry
JT  - Pharmacopsychiatry
JID - 8402938
RN  - 2BMD2GNA4V (Lithium Carbonate)
RN  - 9FN79X2M3F (Lithium)
RN  - 9NEZ333N27 (Sodium)
RN  - RWP5GA015D (Potassium)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biological Transport
MH  - Bipolar Disorder/*blood/drug therapy
MH  - Erythrocytes/*metabolism
MH  - Female
MH  - Humans
MH  - Lithium/*blood/therapeutic use
MH  - Lithium Carbonate
MH  - Male
MH  - Middle Aged
MH  - Potassium/blood
MH  - Sex Factors
MH  - Sodium/blood
EDAT- 1986/03/01 00:00
MHDA- 1986/03/01 00:01
CRDT- 1986/03/01 00:00
PHST- 1986/03/01 00:00 [pubmed]
PHST- 1986/03/01 00:01 [medline]
PHST- 1986/03/01 00:00 [entrez]
AID - 10.1055/s-2007-1017156 [doi]
PST - ppublish
SO  - Pharmacopsychiatry. 1986 Mar;19(2):63-7. doi: 10.1055/s-2007-1017156.