PMID- 30852190
OWN - NLM
STAT- MEDLINE
DCOM- 20190418
LR  - 20190418
IS  - 1879-1026 (Electronic)
IS  - 0048-9697 (Linking)
VI  - 668
DP  - 2019 Jun 10
TI  - Effect of temperature on triclosan toxicity in Pangasianodon hypophthalmus 
      (Sauvage, 1878): Hematology, biochemistry and genotoxicity evaluation.
PG  - 104-114
LID - S0048-9697(19)30955-6 [pii]
LID - 10.1016/j.scitotenv.2019.02.443 [doi]
AB  - The rising level of triclosan (TCS) in aquatic environment is raising concerns 
      and in this context, evaluation of toxicity towards aquatic organisms under 
      varying environmental conditions, especially temperature, is a pre-requisite for 
      a better understanding of the toxic effects on specific metabolic processes. In 
      this report, the mechanistic physiological responses of fish towards varying 
      concentration of TCS at graded temperature were evaluated. The static renewal 
      acute test was performed, and 96 h median lethal concentration (LC(50)) of TCS 
      for Pangasianodon hypophthalmus was estimated and the values were 848.33, 1181.94 
      and 1356.96 mug L(-1) at 25, 30 and 35  degrees C respectively. The chronic study was 
      performed for 30 days at 1/5th and 1/10th concentration of the estimated LC(50) 
      of TCS at 25, 30 and 35  degrees C respectively. The chronic effects resulted in 
      significant decrease in total erythrocyte count (TEC), hemoglobin (Hb), packed 
      cell volume (PCV), mean corpuscular hemoglobin (MCH) and mean cell volume (MCV), 
      while a significant increase in total leukocyte count (TLC), mean corpuscular 
      hemoglobin concentration (MCHC) and red cell distribution width (RDW) was 
      observed in TCS exposed groups at 25-35  degrees C. Further, a significant increase in 
      activity of transaminase enzymes, lactate dehydrogenase (LDH) and antioxidant 
      enzymes (superoxide dismutase) (SOD) and catalase (CAT) except 
      glutathione-S-transferase (GST) in liver and acetylcholinesterase (AChE) in brain 
      of the TCS exposed fish was recorded in all the above temperature range. Severe 
      damage of DNA in nucleus of blood and liver cells, and high micronuclei frequency 
      (MNi) was noticed in TCS exposed groups at 25  degrees C. The report provides convincing 
      evidence for the effect of temperature on TCS toxicity. The findings will help in 
      gaining a better insight into the change in toxicity of TCS in a natural 
      environment where diurnal variations in temperature may be crucial in determining 
      the overall extent of toxicity.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Paul, Tapas
AU  - Paul T
AD  - Aquatic Environment and Health Management Division, ICAR-CIFE, Mumbai 400061, 
      India.
FAU - Shukla, S P
AU  - Shukla SP
AD  - Aquatic Environment and Health Management Division, ICAR-CIFE, Mumbai 400061, 
      India.
FAU - Kumar, Kundan
AU  - Kumar K
AD  - Aquatic Environment and Health Management Division, ICAR-CIFE, Mumbai 400061, 
      India.
FAU - Poojary, Nalini
AU  - Poojary N
AD  - Aquatic Environment and Health Management Division, ICAR-CIFE, Mumbai 400061, 
      India.
FAU - Kumar, Saurav
AU  - Kumar S
AD  - Aquatic Environment and Health Management Division, ICAR-CIFE, Mumbai 400061, 
      India. Electronic address: saurav@cife.edu.in.
LA  - eng
PT  - Journal Article
DEP - 20190301
PL  - Netherlands
TA  - Sci Total Environ
JT  - The Science of the total environment
JID - 0330500
RN  - 0 (Antioxidants)
RN  - 0 (Water Pollutants, Chemical)
RN  - 4NM5039Y5X (Triclosan)
RN  - EC 1.11.1.6 (Catalase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - EC 2.5.1.18 (Glutathione Transferase)
RN  - EC 3.1.1.7 (Acetylcholinesterase)
SB  - IM
MH  - Acetylcholinesterase/metabolism
MH  - Animals
MH  - Antioxidants/metabolism
MH  - Catalase/metabolism
MH  - Catfishes/*physiology
MH  - DNA Damage
MH  - Glutathione Transferase/metabolism
MH  - *Mutagenicity Tests
MH  - Superoxide Dismutase/metabolism
MH  - Triclosan/*toxicity
MH  - Water Pollutants, Chemical/*toxicity
OTO - NOTNLM
OT  - Genotoxicity
OT  - Hematology
OT  - Oxidative stress
OT  - P. hypophthalmus
OT  - Temperature
OT  - Triclosan
EDAT- 2019/03/11 06:00
MHDA- 2019/04/19 06:00
CRDT- 2019/03/11 06:00
PHST- 2018/11/26 00:00 [received]
PHST- 2019/02/24 00:00 [revised]
PHST- 2019/02/27 00:00 [accepted]
PHST- 2019/03/11 06:00 [pubmed]
PHST- 2019/04/19 06:00 [medline]
PHST- 2019/03/11 06:00 [entrez]
AID - S0048-9697(19)30955-6 [pii]
AID - 10.1016/j.scitotenv.2019.02.443 [doi]
PST - ppublish
SO  - Sci Total Environ. 2019 Jun 10;668:104-114. doi: 10.1016/j.scitotenv.2019.02.443. 
      Epub 2019 Mar 1.