PMID- 30852433
OWN - NLM
STAT- MEDLINE
DCOM- 20190613
LR  - 20190613
IS  - 1872-7123 (Electronic)
IS  - 0165-1781 (Linking)
VI  - 274
DP  - 2019 Apr
TI  - Brain-derived neurotrophic factor (BDNF) and bipolar disorder.
PG  - 395-399
LID - S0165-1781(19)30239-2 [pii]
LID - 10.1016/j.psychres.2019.02.051 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) is deemed to be associated with the 
      psychopathology of bipolar I disorder (BD). However, studies focusing on accuracy 
      of BDNF levels to differentiate these patients from healthy controls (HCs) are 
      scarce. Over a discrete twelve-year period, we investigated serum BDNF levels in 
      patients with BD and compared them to age-, sex- and body mass index 
      (BMI)-matched HCs. There were lower serum BDNF levels in 83 samples with BD than 
      in 222 HCs samples (5.7 +/- 4.2 ng/ml vs. 12.2 +/- 7.5 ng/ml, F = 46.784). Pearson's 
      correlation test showed significant positive correlations between Young Mania 
      Rating Scale scores and the BDNF levels among 61 manic patients (gamma = 0.339). The 
      receiver operating characteristic curve analysis showed BDNF levels demonstrated 
      a moderate accuracy of being able to differentiate BD patients from HCs 
      (AUC = 0.801). The most adequate cut-off points of the BDNF level were 6.74 ng/ml 
      (sensitivity = 82.0%, specificity = 63.9%). Our results support that BDNF 
      demonstrated moderate accuracy to distinguish BD patients from HCs. In the 
      future, greater samples would be required to prove these results.
CI  - Copyright (c) 2019. Published by Elsevier B.V.
FAU - Chiou, Yu-Jie
AU  - Chiou YJ
AD  - Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung 
      University College of Medicine, Kaohsiung, Taiwan.
FAU - Huang, Tiao-Lai
AU  - Huang TL
AD  - Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung 
      University College of Medicine, Kaohsiung, Taiwan. Electronic address: 
      a540520@adm.cgmh.org.tw.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190220
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Area Under Curve
MH  - Bipolar Disorder/*blood
MH  - Body Mass Index
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - ROC Curve
MH  - Statistics, Nonparametric
OTO - NOTNLM
OT  - Biomarker
OT  - Bipolar disorder
OT  - Brain-derived neurotrophic factor
EDAT- 2019/03/11 06:00
MHDA- 2019/06/14 06:00
CRDT- 2019/03/11 06:00
PHST- 2019/01/22 00:00 [received]
PHST- 2019/02/19 00:00 [revised]
PHST- 2019/02/20 00:00 [accepted]
PHST- 2019/03/11 06:00 [pubmed]
PHST- 2019/06/14 06:00 [medline]
PHST- 2019/03/11 06:00 [entrez]
AID - S0165-1781(19)30239-2 [pii]
AID - 10.1016/j.psychres.2019.02.051 [doi]
PST - ppublish
SO  - Psychiatry Res. 2019 Apr;274:395-399. doi: 10.1016/j.psychres.2019.02.051. Epub 
      2019 Feb 20.