PMID- 30852582
OWN - NLM
STAT- MEDLINE
DCOM- 20190429
LR  - 20200225
IS  - 1643-3750 (Electronic)
IS  - 1234-1010 (Print)
IS  - 1234-1010 (Linking)
VI  - 25
DP  - 2019 Mar 10
TI  - Decreased Serum Monocyte Chemoattractant Protein-1 (MCP-1) Expression in Patients 
      with Upper Gastrointestinal Bleeding.
PG  - 1822-1827
LID - 10.12659/MSM.911897 [doi]
AB  - BACKGROUND The aim of this study was to investigate the expression of monocyte 
      chemoattractant protein-1 (MCP-1) and its correlation with the blood lipid level 
      in upper gastrointestinal bleeding (UGIB). MATERIAL AND METHODS A total of 118 
      patients with UGIB were enrolled in this study. The relevant indicators for blood 
      lipid levels were detected using a biochemical analyzer. MCP-1 levels in the 
      serum of patients was determined through enzyme-linked immunosorbent assay 
      (ELISA). Statistical Product and Service Solutions (SPSS) 17.0 software was used 
      for the statistical analysis. Two-sample t-test was used for the intergroup 
      comparison. The significant indicators were included in a multivariate logistic 
      regression model to analyze the prognostic factors of UGIB. Pearson analysis was 
      applied to the correlation analysis. P<0.05 suggested that the difference was 
      statistically significant. RESULTS MCP-1 expression levels in patients with UGIB 
      were significantly lower than that in the control group and were even further 
      reduced in patients with massive hemorrhage. The levels of total cholesterol 
      (TC), triglyceride (TG), and low-density lipoprotein (LDL) in the serum of 
      patients with UGIB were decreased compared with those in the control group and 
      these indicators of the blood lipid level were decreased much more in patients 
      with massive hemorrhage. The MCP-1 expression was positively correlated with the 
      levels of TC, TG, and LDL in serum. MCP-1 and TC were the prognostic influencing 
      factors of UGIB. CONCLUSIONS Serum MCP-1 expression was significantly decreased 
      in patients with UGIB and correlated with blood lipid level, suggesting it might 
      be a prognostic factor for UGB.
FAU - Xing, Guohui
AU  - Xing G
AD  - Department of Digestive Medicine, Rizhao Traditional Chinese Medicine Hospital, 
      Rizhao, Shandong, China (mainland).
FAU - Wang, Lili
AU  - Wang L
AD  - Department of Infectious Diseases, Qingdao Central Hospital, Qingdao, Shandong, 
      China (mainland).
FAU - Li, Wei
AU  - Li W
AD  - Department of General Surgery, Rizhao Traditional Chinese Medicine Hospital, 
      Rizhao, Shandong, China (mainland).
FAU - Xu, Yanling
AU  - Xu Y
AD  - Department of Digestive Medicine, Rizhao Traditional Chinese Medicine Hospital, 
      Rizhao, Shandong, China (mainland).
FAU - Shi, Xia
AU  - Shi X
AD  - Department of Digestive Medicine, Rizhao Traditional Chinese Medicine Hospital, 
      Rizhao, Shandong, China (mainland).
FAU - Xu, Guixing
AU  - Xu G
AD  - Department of General Surgery, Rizhao Traditional Chinese Medicine Hospital, 
      Rizhao, Shandong, China (mainland).
FAU - Zhang, Jiajun
AU  - Zhang J
AD  - Department of Digestive Medicine, Rizhao Traditional Chinese Medicine Hospital, 
      Rizhao, Shandong, China (mainland).
LA  - eng
PT  - Journal Article
DEP - 20190310
PL  - United States
TA  - Med Sci Monit
JT  - Medical science monitor : international medical journal of experimental and 
      clinical research
JID - 9609063
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Lipids)
RN  - 0 (Lipoproteins, LDL)
RN  - 0 (Triglycerides)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Chemokine CCL2/*blood
MH  - Cholesterol/blood
MH  - Female
MH  - Gastrointestinal Hemorrhage/*blood
MH  - Humans
MH  - Lipids/blood
MH  - Lipoproteins, LDL/blood
MH  - Male
MH  - Middle Aged
MH  - Transcriptome
MH  - Triglycerides/blood
MH  - Upper Gastrointestinal Tract
PMC - PMC6422425
COIS- Conflict of interest None.
EDAT- 2019/03/11 06:00
MHDA- 2019/04/30 06:00
PMCR- 2019/03/10
CRDT- 2019/03/11 06:00
PHST- 2019/03/11 06:00 [entrez]
PHST- 2019/03/11 06:00 [pubmed]
PHST- 2019/04/30 06:00 [medline]
PHST- 2019/03/10 00:00 [pmc-release]
AID - 911897 [pii]
AID - 10.12659/MSM.911897 [doi]
PST - epublish
SO  - Med Sci Monit. 2019 Mar 10;25:1822-1827. doi: 10.12659/MSM.911897.