PMID- 30852704
OWN - NLM
STAT- MEDLINE
DCOM- 20190610
LR  - 20200225
IS  - 1875-8312 (Electronic)
IS  - 1569-5794 (Linking)
VI  - 35
IP  - 6
DP  - 2019 Jun
TI  - Validation of contrast enhanced cine steady-state free precession and T2-weighted 
      CMR for assessment of ischemic myocardial area-at-risk in the presence of 
      reperfusion injury.
PG  - 1039-1045
LID - 10.1007/s10554-019-01569-x [doi]
AB  - The purpose of the study was to validate by histopathology, contrast enhanced 
      cine steady-state free precession and T2-weighted CMR for the assessment of 
      ischemic myocardial area-at-risk (AAR) in the presence of microvascular 
      obstruction (MVO). Eleven anesthetized pigs underwent CMR 7 to 10 days post 
      infarction. The area-at-risk was measured from T2-weighted fast spin echo 
      (T2-STIR) and contrast-enhanced steady-state free precession magnetic resonance 
      imaging (CE-SSFP) images using semi-automated algorithms based on a priori 
      knowledge of perfusion territory. Also, late gadolinium enhancement (LGE) was 
      performed to measure final infarct size (FIS). Histopathological comparison with 
      Evans blue dye to define AAR and triphenyltetrazolium chloride to define FIS 
      served as the reference. All infarcts demonstrated MVO on LGE images. 
      Bland-Altman analysis showed no significant bias in AAR or myocardial salvage 
      between T2-STIR and CE-SSFP or between CMR and histopathology. The mean 
      differences +/- 2SD from Bland-Altman analysis were: AAR: Evans Blue vs. T2-STIR 
      [0.7%; + 13.5%; - 12.1%]; AAR: Evans Blue vs. CE-SSFP [0.1%; + 13.8%; - 13.7%]; 
      AAR: T2-STIR vs. CE-SSFP [0.7%; + 6.2%; - 4.9%]; Salvage: Evans Blue - TTC vs. 
      T2-STIR-LGE [0.8%; + 11.1%; - 9.6%]; Salvage: Evans Blue - TTC vs. CE-SSFP-LGE 
      [0.1%; + 9.9%; - 9.6%]; Salvage: CE-SSFP-LGE vs. T2-STIR-LGE [0.7%; + 6.2%; 
      - 4.9%]. Both T2-STIR and CE-SSFP sequences allow for unbiased quantification of 
      AAR in the presence of ischemia/reperfusion injury when analysed by 
      semi-automated algorithms. These experimental data, which was validated by 
      histopathology, supports the use of CMR for the assessment of myocardial salvage 
      during the subacute phase.
FAU - Hansen, Esben Sovso Szocska
AU  - Hansen ESS
AD  - The MR Research Centre and Department of Clinical Medicine, Aarhus University 
      Hospital Skejby, Palle Juul-Jensens Boulevard 99, 8200, Aarhus N, Denmark.
AD  - Danish Diabetes Academy, Odense, Denmark.
FAU - Pedersen, Steen Fjord
AU  - Pedersen SF
AD  - Department of Cardiothoracic and Vascular Surgery T, Aarhus University Hospital 
      Skejby, Palle Juul-Jensens Boulevard 99, 8200, Aarhus N, Denmark.
FAU - Pedersen, Steen Bonlokke
AU  - Pedersen SB
AD  - Department of Endocrinology and Internal Medicine, Aarhus University Hospital 
      THG, Tage-Hansens Gade 2, 8000, Aarhus C, Denmark.
FAU - Botker, Hans Erik
AU  - Botker HE
AD  - Department of Cardiology, Aarhus University Hospital Skejby, Palle Juul-Jensens 
      Boulevard 99, 8200, Aarhus N, Denmark.
FAU - Kim, Won Yong
AU  - Kim WY
AUID- ORCID: 0000-0003-1302-1671
AD  - The MR Research Centre and Department of Clinical Medicine, Aarhus University 
      Hospital Skejby, Palle Juul-Jensens Boulevard 99, 8200, Aarhus N, Denmark. 
      yong.kim@clin.au.dk.
AD  - Department of Cardiology, Aarhus University Hospital Skejby, Palle Juul-Jensens 
      Boulevard 99, 8200, Aarhus N, Denmark. yong.kim@clin.au.dk.
LA  - eng
PT  - Journal Article
PT  - Validation Study
DEP - 20190309
PL  - United States
TA  - Int J Cardiovasc Imaging
JT  - The international journal of cardiovascular imaging
JID - 100969716
RN  - 0 (Contrast Media)
RN  - 0 (Organometallic Compounds)
RN  - 1BJ477IO2L (gadobutrol)
SB  - IM
MH  - Animals
MH  - Contrast Media/*administration & dosage
MH  - Disease Models, Animal
MH  - Female
MH  - Image Interpretation, Computer-Assisted
MH  - Magnetic Resonance Imaging, Cine/*methods
MH  - Myocardial Infarction/*diagnostic imaging/pathology
MH  - Myocardial Reperfusion Injury/*diagnostic imaging/pathology
MH  - Myocardium/*pathology
MH  - Observer Variation
MH  - Organometallic Compounds/*administration & dosage
MH  - Predictive Value of Tests
MH  - Reproducibility of Results
MH  - Sus scrofa
MH  - Tissue Survival
OTO - NOTNLM
OT  - Edema
OT  - Final infarct size
OT  - Magnetic resonance imaging
OT  - Myocardium at risk
OT  - Salvage
EDAT- 2019/03/11 06:00
MHDA- 2019/06/14 06:00
CRDT- 2019/03/11 06:00
PHST- 2018/11/23 00:00 [received]
PHST- 2019/02/21 00:00 [accepted]
PHST- 2019/03/11 06:00 [pubmed]
PHST- 2019/06/14 06:00 [medline]
PHST- 2019/03/11 06:00 [entrez]
AID - 10.1007/s10554-019-01569-x [pii]
AID - 10.1007/s10554-019-01569-x [doi]
PST - ppublish
SO  - Int J Cardiovasc Imaging. 2019 Jun;35(6):1039-1045. doi: 
      10.1007/s10554-019-01569-x. Epub 2019 Mar 9.