PMID- 30853182
OWN - NLM
STAT- MEDLINE
DCOM- 20200210
LR  - 20200210
IS  - 1090-2104 (Electronic)
IS  - 0006-291X (Linking)
VI  - 512
IP  - 1
DP  - 2019 Apr 23
TI  - The long noncoding RNA ST7-AS1 promotes laryngeal squamous cell carcinoma by 
      stabilizing CARM1.
PG  - 34-40
LID - S0006-291X(19)30244-X [pii]
LID - 10.1016/j.bbrc.2019.02.057 [doi]
AB  - The laryngeal squamous cell carcinoma (LSCC) represents a malignant cancer and 
      contributes largely to head and neck tumorigenesis. The molecular mechanisms for 
      LSCC progression are poorly understood. In current work, we identified long 
      non-coding RNA (lncRNA) termed suppressor of tumorigenicity 7 antisense RNA 1 
      (ST7-AS1) as an oncogenic factor in LSCC. ST7-AS1 is frequently overexpressed in 
      LSCC tissues and cell lines. ST7-AS1 is required for the malignancy of LSCC cells 
      through migration, tumor sphere formation assay and in vivo implantation. 
      Mechanistically, ST7-AS1 could interact with CARM1, a well characterized protein 
      arginine methyltransferase and protect CARM1 from ubiquitin-dependent 
      degradation. CARM1 can methylate Sox-2, a pluripotent transcription factor. Thus, 
      ST7-AS1 might mediate its oncogenic effect by signaling through CARM1-Sox-2 axis 
      to enhance Sox-2 self-association and transactivation activity. Collectively, we 
      have unraveled a ST7-AS1/CARM1/Sox-2 signaling axis in LSCC and may have created 
      novel interconnections between noncoding RNAs and cancer development.
CI  - Copyright (c) 2019 Elsevier Inc. All rights reserved.
FAU - Qin, Haiping
AU  - Qin H
AD  - Department of Otolaryngology, Head and Neck Surgery, Liaocheng People's Hospital, 
      Liaocheng, 252000, Shandong, China. Electronic address: hpqin_lph@yeah.net.
FAU - Xu, Jinxia
AU  - Xu J
AD  - Department of Otolaryngology, Head and Neck Surgery, Liaocheng People's Hospital, 
      Liaocheng, 252000, Shandong, China.
FAU - Gong, Lili
AU  - Gong L
AD  - Department of Otolaryngology, Head and Neck Surgery, Liaocheng People's Hospital, 
      Liaocheng, 252000, Shandong, China.
FAU - Jiang, Baolu
AU  - Jiang B
AD  - Department of Otolaryngology, Head and Neck Surgery, Liaocheng People's Hospital, 
      Liaocheng, 252000, Shandong, China.
FAU - Zhao, Wei
AU  - Zhao W
AD  - Department of Otolaryngology, Head and Neck Surgery, Liaocheng People's Hospital, 
      Liaocheng, 252000, Shandong, China.
LA  - eng
PT  - Journal Article
DEP - 20190307
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Carcinogens)
RN  - 0 (RNA, Antisense)
RN  - 0 (RNA, Long Noncoding)
RN  - 0 (SOX2 protein, human)
RN  - 0 (SOXB1 Transcription Factors)
RN  - 0 (ST7 protein, human)
RN  - 0 (Tumor Suppressor Proteins)
RN  - EC 2.1.1.319 (Protein-Arginine N-Methyltransferases)
RN  - EC 2.1.1.319 (coactivator-associated arginine methyltransferase 1)
RN  - EC 3.4.25.1 (Proteasome Endopeptidase Complex)
SB  - IM
CIN - Biochem Biophys Res Commun. 2019 Dec 17;520(4):671. PMID: 31761068
MH  - Carcinogenesis/genetics
MH  - Carcinogens/metabolism
MH  - Carcinoma, Squamous Cell/*genetics/*metabolism
MH  - Cell Line, Tumor
MH  - Disease Progression
MH  - Enzyme Stability/genetics
MH  - Gene Expression Regulation, Neoplastic
MH  - Gene Knockdown Techniques
MH  - Humans
MH  - Laryngeal Neoplasms/*genetics/*metabolism
MH  - Proteasome Endopeptidase Complex/metabolism
MH  - Protein-Arginine N-Methyltransferases/*metabolism
MH  - Proteolysis
MH  - RNA, Antisense/genetics/metabolism
MH  - RNA, Long Noncoding/*genetics/*metabolism
MH  - SOXB1 Transcription Factors/metabolism
MH  - Tumor Suppressor Proteins/genetics
OTO - NOTNLM
OT  - CARM1
OT  - Laryngeal squamous cell carcinoma
OT  - ST7-AS1
OT  - Sox-2
OT  - lncRNA
EDAT- 2019/03/12 06:00
MHDA- 2020/02/11 06:00
CRDT- 2019/03/12 06:00
PHST- 2019/01/31 00:00 [received]
PHST- 2019/02/11 00:00 [accepted]
PHST- 2019/03/12 06:00 [pubmed]
PHST- 2020/02/11 06:00 [medline]
PHST- 2019/03/12 06:00 [entrez]
AID - S0006-291X(19)30244-X [pii]
AID - 10.1016/j.bbrc.2019.02.057 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2019 Apr 23;512(1):34-40. doi: 
      10.1016/j.bbrc.2019.02.057. Epub 2019 Mar 7.