PMID- 3085407
OWN - NLM
STAT- MEDLINE
DCOM- 19860530
LR  - 20200716
IS  - 0372-9311 (Print)
IS  - 0372-9311 (Linking)
IP  - 1
DP  - 1986 Jan
TI  - [Immunogenicity of a chemical typhus vaccine and of a corpuscular radioantigen 
      obtained from Rickettsia prowazekii].
PG  - 73-6
AB  - The protective activity of chemical typhus vaccine and R. prowazekii corpuscular 
      radioantigen (CRA) was studied. Guinea pigs were immunized with doses of 32 and 
      48 antigenic units. Antibody production was assayed in the complement fixation 
      test. On days 7, 15, 21, 30 and 60 after immunization the animals were challenged 
      with R. prowazekii introduced in an amount of 10(5) minimum embryonal infective 
      doses (MEID). On day 30 some of the animals were challenged with 10(3) MEID of R. 
      typhi. The results demonstrated that both preparations were highly immunogenic 
      and capable of protecting most of the animals from 10(5) MEID of R. prowazekii. 
      Immunity developed earlier after immunization with CRA. The guinea pigs immunized 
      with CRA, purified in percoll density gradient, and challenged with 10(3) MEID of 
      R. typhi on day 30 showed a high level of cross immunity. In all control animals 
      high fever and periorchitis were observed.
FAU - Pushkareva, V I
AU  - Pushkareva VI
FAU - Kekcheeva, N G
AU  - Kekcheeva NG
FAU - Kokorin, I N
AU  - Kokorin IN
LA  - rus
PT  - Comparative Study
PT  - English Abstract
PT  - Journal Article
TT  - Immunogennost' khimicheskoi sypnotifoznoi vaktsiny i korpuskuliarnogo 
      radioantigena, poluchennogo iz Rickettsia prowazekii.
PL  - Russia (Federation)
TA  - Zh Mikrobiol Epidemiol Immunobiol
JT  - Zhurnal mikrobiologii, epidemiologii i immunobiologii
JID - 0415217
RN  - 0 (Antigens, Bacterial)
RN  - 0 (Antigens, Surface)
RN  - 0 (Bacterial Vaccines)
SB  - IM
MH  - Animals
MH  - Antigens, Bacterial/*immunology/radiation effects
MH  - Antigens, Surface/immunology
MH  - Bacterial Vaccines/*immunology
MH  - Cross Reactions
MH  - Dose-Response Relationship, Immunologic
MH  - Gamma Rays
MH  - Guinea Pigs
MH  - Immunity
MH  - Immunization
MH  - Male
MH  - Rickettsia prowazekii/*immunology
MH  - Time Factors
MH  - Typhus, Endemic Flea-Borne/immunology/prevention & control
MH  - Typhus, Epidemic Louse-Borne/immunology/prevention & control
EDAT- 1986/01/01 00:00
MHDA- 1986/01/01 00:01
CRDT- 1986/01/01 00:00
PHST- 1986/01/01 00:00 [pubmed]
PHST- 1986/01/01 00:01 [medline]
PHST- 1986/01/01 00:00 [entrez]
PST - ppublish
SO  - Zh Mikrobiol Epidemiol Immunobiol. 1986 Jan;(1):73-6.