PMID- 30854307
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220408
IS  - 2225-319X (Print)
IS  - 2304-1021 (Electronic)
IS  - 2225-319X (Linking)
VI  - 8
IP  - 1
DP  - 2019 Jan
TI  - Outcomes of venoarterial extracorporeal membrane oxygenation for refractory 
      cardiogenic shock: systematic review and meta-analysis.
PG  - 1-8
LID - 10.21037/acs.2018.11.09 [doi]
AB  - BACKGROUND: Despite advances in management techniques and medical therapy, 
      refractory cardiogenic shock remains a life-threatening condition with high 
      mortality rates. The present systematic review and meta-analysis aims to explore 
      the outcomes associated with venoarterial extracorporeal membrane oxygenation 
      (VA-ECMO) use in the setting of refractory cardiogenic shock, stratified per 
      survivorship. METHODS: A literature search was performed using three electronic 
      databases from the date of their inception up to June 2018. The literature search 
      and subsequent data extraction were performed by two independent reviewers. 
      Digitized survival data were extracted from Kaplan-Meier curves in order to 
      re-create the original patient data using an iterative algorithm and were 
      subsequently aggregated for analysis. RESULTS: Fifty-two studies were included, 
      with 44 undergoing quantitative analysis. A total of 17,515 patients were 
      identified, with a mean age of 58.4+/-9.4 years and a mean duration of ECMO support 
      of 5.1+/-2.6 days; 68.7% of the patients were male. Aggregated survival rates at 1, 
      2, 3 and 5 years were 36.7%, 34.8%, 33.8% and 29.9%, respectively. CONCLUSIONS: 
      The present systematic review illustrates the expected survival results for 
      VA-ECMO in the intermediate- to long-term. Extended follow-up and standardized 
      reporting measures are urgently needed in order to carry out more definitive 
      subgroup analyses.
FAU - Wilson-Smith, Ashley R
AU  - Wilson-Smith AR
AD  - The Collaborative Research Group (CORE), Macquarie University, Sydney, Australia.
AD  - The University of New South Wales, Faculty of Medicine, Sydney, Australia.
FAU - Bogdanova, Yulia
AU  - Bogdanova Y
AD  - The University of New South Wales, Faculty of Medicine, Sydney, Australia.
FAU - Roydhouse, Stephanie
AU  - Roydhouse S
AD  - The University of New South Wales, Faculty of Medicine, Sydney, Australia.
FAU - Phan, Kevin
AU  - Phan K
AD  - The Collaborative Research Group (CORE), Macquarie University, Sydney, Australia.
FAU - Tian, David H
AU  - Tian DH
AD  - The Collaborative Research Group (CORE), Macquarie University, Sydney, Australia.
AD  - Royal North Shore Hospital, Sydney, Australia.
FAU - Yan, Tristan D
AU  - Yan TD
AD  - The Collaborative Research Group (CORE), Macquarie University, Sydney, Australia.
AD  - Department of Cardiothoracic Surgery, Royal Prince Alfred Hospital (RPA), 
      Camperdown, Australia.
FAU - Loforte, Antonio
AU  - Loforte A
AD  - Department of Cardiovascular Surgery and Transplantation, St. Orsola-Malpighi 
      Hospital, University of Bologna, Bologna, Italy.
LA  - eng
PT  - Journal Article
PL  - China
TA  - Ann Cardiothorac Surg
JT  - Annals of cardiothoracic surgery
JID - 101605877
PMC - PMC6379189
OTO - NOTNLM
OT  - ECLS
OT  - Extracorporeal membrane oxygenation (ECMO)
OT  - refractory cardiogenic shock
COIS- Conflicts of Interest: The authors have no conflicts of interest to declare.
EDAT- 2019/03/12 06:00
MHDA- 2019/03/12 06:01
PMCR- 2019/01/01
CRDT- 2019/03/12 06:00
PHST- 2019/03/12 06:00 [entrez]
PHST- 2019/03/12 06:00 [pubmed]
PHST- 2019/03/12 06:01 [medline]
PHST- 2019/01/01 00:00 [pmc-release]
AID - acs-08-01-1 [pii]
AID - 10.21037/acs.2018.11.09 [doi]
PST - ppublish
SO  - Ann Cardiothorac Surg. 2019 Jan;8(1):1-8. doi: 10.21037/acs.2018.11.09.