PMID- 30854358
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220408
IS  - 2292-5503 (Print)
IS  - 2292-5511 (Electronic)
IS  - 2292-5503 (Linking)
VI  - 27
IP  - 1
DP  - 2019 Feb
TI  - A Prospective Randomized Controlled Trial of Aspiration and Fibrin Sealant Use 
      Versus Aspiration Alone in the Treatment of Dorsal Wrist Ganglia.
PG  - 22-28
LID - 10.1177/2292550318800325 [doi]
AB  - PURPOSE: Multiple treatments for dorsal wrist ganglia (DWG) exist but have high 
      recurrence rates. We investigated whether aspiration followed by injection of 
      Tisseel is more effective at reducing the DWG recurrence rate than aspiration 
      alone. METHODS: Adults with untreated DWG were randomly assigned to aspiration 
      alone (A) or aspiration followed by Tisseel injection (AT). Patients were 
      measured at baseline, 1, 6, and 12 months. Primary outcome was the rate of 
      recurrence. Secondary outcomes included recurrent ganglion size and maximum pain 
      experienced from the ganglion. Continuous data were compared with Student t tests 
      and Mann-Whitney U tests. Categorical data were compared with chi(2) tests and 
      Fisher exact tests. Treatment effect was reported as relative risk or mean 
      differences (MD) with 95% confidence intervals. RESULTS: Seventy-nine patients 
      were randomized to the A (n = 39) or AT (n = 40) group. Twenty-five patients were 
      lost to follow-up. There were no differences in recurrence risk between groups at 
      1, 6, or 12 months (P > .05). Ganglia were significantly smaller for both groups 
      at 1 month versus baseline (P < .001). The A group demonstrated a significantly 
      larger decrease in size at 1 month versus the AT group (MD = 0.75 cm(2), 95% 
      confidence interval: 0.07-1.43, P = .03). Both groups experienced significantly 
      less pain at 1, 6, and 12 months (P < .03), but this was not significantly 
      different between groups. CONCLUSION: Aspiration and Tisseel injection does not 
      decrease DWG recurrence versus aspiration alone. Both interventions produced a 
      significant decrease in pain. Although aspiration alone carries a high recurrence 
      risk, it may provide sufficient symptomatic relief for patients with DWG.
FAU - Hatchell, Alexandra
AU  - Hatchell A
AD  - Division of Plastic Surgery, Department of Surgery, McMaster University, 
      Hamilton, Ontario, Canada.
FAU - Meathrel, Kimberly
AU  - Meathrel K
AD  - Division of Plastic Surgery, Department of Surgery, Queen's University, Kingston, 
      Ontario, Canada.
FAU - Farrokhyar, Forough
AU  - Farrokhyar F
AD  - Departments of Surgery & Heath, Evidence and Impact, McMaster University, 
      Hamilton, Ontario, Canada.
FAU - Hynes, Nicolas
AU  - Hynes N
AD  - Division of Plastic Surgery, Department of Surgery, McMaster University, 
      Hamilton, Ontario, Canada.
LA  - eng
PT  - Journal Article
DEP - 20181216
PL  - United States
TA  - Plast Surg (Oakv)
JT  - Plastic surgery (Oakville, Ont.)
JID - 101623618
PMC - PMC6399779
OTO - NOTNLM
OT  - aspiration
OT  - fibrin tissue adhesive
OT  - ganglion
OT  - pain
OT  - recurrence
OT  - treatment
OT  - wrist
COIS- Declaration of Conflicting Interests: The author(s) declared no potential 
      conflicts of interest with respect to the research, authorship, and/or 
      publication of this article.
EDAT- 2019/03/12 06:00
MHDA- 2019/03/12 06:01
PMCR- 2020/02/01
CRDT- 2019/03/12 06:00
PHST- 2019/03/12 06:00 [entrez]
PHST- 2019/03/12 06:00 [pubmed]
PHST- 2019/03/12 06:01 [medline]
PHST- 2020/02/01 00:00 [pmc-release]
AID - 10.1177_2292550318800325 [pii]
AID - 10.1177/2292550318800325 [doi]
PST - ppublish
SO  - Plast Surg (Oakv). 2019 Feb;27(1):22-28. doi: 10.1177/2292550318800325. Epub 2018 
      Dec 16.