PMID- 30854641
OWN - NLM
STAT- MEDLINE
DCOM- 20200413
LR  - 20200413
IS  - 1528-1167 (Electronic)
IS  - 0013-9580 (Linking)
VI  - 60
IP  - 4
DP  - 2019 Apr
TI  - Anxiety and depression symptoms disrupt resting state connectivity in patients 
      with genetic generalized epilepsies.
PG  - 679-688
LID - 10.1111/epi.14687 [doi]
AB  - OBJECTIVE: To analyze the lifetime trajectories in genetic generalized epilepsies 
      (GGEs) and investigate the impact of symptoms of anxiety and depression on 
      resting state functional connectivity (FC). METHODS: Seventy-four GGE patients 
      were classified according to the pharmacological response as seizure-free (12 
      patients), pharmacoresistant (PhR; 14 patients), and fluctuating (FL; 48 
      patients). Fifty-four subjects completed both the Beck Depression Inventory (BDI) 
      and Beck Anxiety Inventory (BAI), and 38 also underwent 3-T resting state 
      functional magnetic resonance imaging. These 38 patients were subdivided into a 
      positive group (13 patients with concurrent symptoms of depression and anxiety) 
      and a negative group (21 asymptomatic patients and four with mild anxiety or 
      depression symptoms). For FC analysis of resting state networks, we matched 38 
      healthy asymptomatic volunteers and used the UF2C toolbox running on 
      MATLAB2017/SPM12. RESULTS: The PhR group presented shorter duration of epilepsy 
      (P = 0.016) and follow-up (P < 0.001) compared to the FL group. The PhR group 
      showed higher levels (median = 20) on the BAI and BDI. Myoclonic seizures were 
      the most difficult to control, as 50% of subjects persisted with them at last 
      appointment, compared to generalized tonic-clonic seizures and absence seizures 
      (<40%). Patients with concurrent anxiety and depression symptoms were 7.7 times 
      more likely to exhibit pharmacoresistant seizures, although an increase of 1 year 
      of epilepsy duration was associated with a decrease in the odds of presenting 
      pharmacoresistance by a factor of 0.9. Overall, FC was altered between default 
      mode network (DMN) and visuospatial/dorsal attention. However, only the positive 
      group displayed abnormal FC between DMN and left executive control network, and 
      between salience and visuospatial/dorsal attention. SIGNIFICANCE: Our findings 
      may help clinicians to have a better understanding of GGE clinical course and 
      increase attention to the potential relationship of psychopathologies and brain 
      connectivity.
CI  - Wiley Periodicals, Inc. (c) 2019 International League Against Epilepsy.
FAU - Garcia, Danielle Dos Santos
AU  - Garcia DDS
AUID- ORCID: 0000-0003-3965-6376
AD  - Laboratory of Neuroimaging, University of Campinas, Campinas, Brazil.
FAU - Polydoro, Marina Sconzo
AU  - Polydoro MS
AD  - Laboratory of Neuroimaging, University of Campinas, Campinas, Brazil.
FAU - Alvim, Marina Kutsodontis Machado
AU  - Alvim MKM
AD  - Laboratory of Neuroimaging, University of Campinas, Campinas, Brazil.
AD  - Department of Neurology, University of Campinas, Campinas, Brazil.
FAU - Ishikawa, Akari
AU  - Ishikawa A
AD  - Laboratory of Neuroimaging, University of Campinas, Campinas, Brazil.
FAU - Moreira, Jose Carlos Vasques
AU  - Moreira JCV
AD  - Laboratory of Neuroimaging, University of Campinas, Campinas, Brazil.
FAU - Nogueira, Mateus Henrique
AU  - Nogueira MH
AD  - Laboratory of Neuroimaging, University of Campinas, Campinas, Brazil.
FAU - Zanao, Tamires Araujo
AU  - Zanao TA
AUID- ORCID: 0000-0001-7868-4332
AD  - Laboratory of Neuroimaging, University of Campinas, Campinas, Brazil.
FAU - de Campos, Brunno Machado
AU  - de Campos BM
AUID- ORCID: 0000-0003-1261-8257
AD  - Laboratory of Neuroimaging, University of Campinas, Campinas, Brazil.
FAU - Betting, Luiz Eduardo Gomes Garcia
AU  - Betting LEGG
AD  - Department of Neurology and Psychiatry, School of Medicine, Sao Paulo State 
      University, Botucatu, Brazil.
FAU - Cendes, Fernando
AU  - Cendes F
AUID- ORCID: 0000-0001-9336-9568
AD  - Laboratory of Neuroimaging, University of Campinas, Campinas, Brazil.
AD  - Department of Neurology, University of Campinas, Campinas, Brazil.
FAU - Yasuda, Clarissa L
AU  - Yasuda CL
AUID- ORCID: 0000-0001-9084-7173
AD  - Laboratory of Neuroimaging, University of Campinas, Campinas, Brazil.
AD  - Department of Neurology, University of Campinas, Campinas, Brazil.
LA  - eng
GR  - 2016/03307-8/FAPESP/International
GR  - 2015/09273-5/FAPESP/International
GR  - 2013/07559-3/FAPESP/International
GR  - 308764/2015-3/CNPQ/International
GR  - 402133/2017-0/CNPQ/International
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190310
PL  - United States
TA  - Epilepsia
JT  - Epilepsia
JID - 2983306R
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Anxiety/complications/*physiopathology
MH  - Brain/*physiopathology
MH  - Child
MH  - Depression/complications/*physiopathology
MH  - Epilepsy, Generalized/*physiopathology/*psychology
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Middle Aged
MH  - Neural Pathways/physiopathology
MH  - Young Adult
OTO - NOTNLM
OT  - default mode network
OT  - executive control network
OT  - pharmacological response
OT  - psychopathologies
OT  - salience network
OT  - seizure control
EDAT- 2019/03/12 06:00
MHDA- 2020/04/14 06:00
CRDT- 2019/03/12 06:00
PHST- 2018/03/07 00:00 [received]
PHST- 2019/02/12 00:00 [revised]
PHST- 2019/02/12 00:00 [accepted]
PHST- 2019/03/12 06:00 [pubmed]
PHST- 2020/04/14 06:00 [medline]
PHST- 2019/03/12 06:00 [entrez]
AID - 10.1111/epi.14687 [doi]
PST - ppublish
SO  - Epilepsia. 2019 Apr;60(4):679-688. doi: 10.1111/epi.14687. Epub 2019 Mar 10.