PMID- 30856155
OWN - NLM
STAT- MEDLINE
DCOM- 20200724
LR  - 20200724
IS  - 1095-9114 (Electronic)
IS  - 0895-3996 (Linking)
VI  - 27
IP  - 3
DP  - 2019
TI  - A pilot study of low-dose CT perfusion imaging (LDCTPI) technology in patients 
      with triple-negative breast cancer.
PG  - 443-451
LID - 10.3233/XST-180465 [doi]
AB  - PURPOSE: To investigate associations between the clinicopathologic features and 
      CT perfusion parameters of triple-negative breast cancer (TNBC) and non-TNBC 
      using low-dose computed tomography perfusion imaging (LDCTPI), and to find 
      potential clinical applications in the prognosis assessment of TNBC. MATERIALS 
      AND METHODS: A total of 60 patients with breast cancer confirmed by pathological 
      examination were studied prospectively using LDCTPI on a 64-slice spiral CT 
      scanner. The acquired volume data were used for calculations, mapping, and 
      analysis by using a tumor perfusion protocol in the CT perfusion software package 
      to measure 2 parameters namely, blood flow (BF), and permeability surface (PS) 
      area product. Patients were grouped into TNBC (n = 27) and non-TNBC (n = 33) 
      subtypes. Associations between these two subtypes and clinicopathologic 
      characteristics were evaluated by both univariate and multivariate logistic 
      regression. CT perfusion parameters values were compared for clinicopathologic 
      characteristics using independent 2-sample t test. RESULTS: TNBC displayed higher 
      CT perfusion parameters values (BF: 57.56+/-10.94 vs 52.70+/-7.79 mL/100 g/min, 
      p = 0.006; PS: 38.98+/-9.46 vs 33.39+/-8.07 mL/100 g/min, p = 0.001) than non-TNBC. 
      In addition, breast cancer with poorly histologic grade or positive Ki-67 
      expression showed higher BF and PS values than those with well and moderately 
      histologic grade or negative Ki-67 expression (p < 0.05). TNBC had poorer 
      histologic grade (P = 0.032) and higher Ki-67 expression (P = 0.013) than 
      non-TNBC. CONCLUSION: LDCTPI is a functional imaging technology from the 
      perspective of hemodynamics with potential of clinical applications. The BF and 
      PS values were higher in TNBC patient group than non-TNBC group. TNBC patients 
      also have poorer clinicopathologic outcome.
FAU - Sun, Zong-Qiong
AU  - Sun ZQ
AD  - Department of Radiology, Affiliated Hospital of Jiangnan University, The Fourth 
      People's Hospital of Wuxi City, Wuxi, Jiangsu, China.
FAU - Hu, Shu-Dong
AU  - Hu SD
AD  - Department of Radiology, Affiliated Hospital of Jiangnan University, The Fourth 
      People's Hospital of Wuxi City, Wuxi, Jiangsu, China.
FAU - Shao, Lin
AU  - Shao L
AD  - Department of Radiology, Affiliated Hospital of Jiangnan University, The Fourth 
      People's Hospital of Wuxi City, Wuxi, Jiangsu, China.
FAU - Jin, Lin-Fang
AU  - Jin LF
AD  - Department of Pathology, Affiliated Hospital of Jiangnan University, The Fourth 
      People's Hospital of Wuxi City, Wuxi, Jiangsu, China.
FAU - Lv, Qing
AU  - Lv Q
AD  - Department of Breast Surgery, Affiliated Hospital of Jiangnan University, The 
      Fourth People's Hospital of Wuxi City, Wuxi, Jiangsu, China.
FAU - Li, Yao-Sen
AU  - Li YS
AD  - Department of Radiology, Wuxi Huishan Traditional Chinese Medicine Hospital, 
      Wuxi, Jiangsu, China.
FAU - Yan, Gen
AU  - Yan G
AD  - Department of Radiology, Affiliated Hospital of Jiangnan University, The Fourth 
      People's Hospital of Wuxi City, Wuxi, Jiangsu, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Xray Sci Technol
JT  - Journal of X-ray science and technology
JID - 9000080
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Perfusion Imaging/*methods
MH  - Pilot Projects
MH  - Prognosis
MH  - Radiographic Image Interpretation, Computer-Assisted
MH  - Software
MH  - Tomography, Spiral Computed/*methods
MH  - Triple Negative Breast Neoplasms/blood supply/*diagnostic imaging/pathology
OTO - NOTNLM
OT  - Triple-negative breast cancer
OT  - X-ray
OT  - clinicopathologic features
OT  - computed tomography
OT  - perfusion
OT  - prognosis
EDAT- 2019/03/12 06:00
MHDA- 2020/07/25 06:00
CRDT- 2019/03/12 06:00
PHST- 2019/03/12 06:00 [pubmed]
PHST- 2020/07/25 06:00 [medline]
PHST- 2019/03/12 06:00 [entrez]
AID - XST180465 [pii]
AID - 10.3233/XST-180465 [doi]
PST - ppublish
SO  - J Xray Sci Technol. 2019;27(3):443-451. doi: 10.3233/XST-180465.