PMID- 30856574
OWN - NLM
STAT- MEDLINE
DCOM- 20190418
LR  - 20190418
IS  - 1879-1026 (Electronic)
IS  - 0048-9697 (Linking)
VI  - 668
DP  - 2019 Jun 10
TI  - Polycyclic aromatic hydrocarbons in breast milk of obese vs normal women: Infant 
      exposure and risk assessment.
PG  - 658-667
LID - S0048-9697(19)30890-3 [pii]
LID - 10.1016/j.scitotenv.2019.02.381 [doi]
AB  - Biomonitoring of human breast milk is one of the best ways to identify body 
      burdens of contaminants and associated risk estimation. The objectives of the 
      current study were to evaluate milk concentrations of persistent organic 
      pollutants (POPs), mainly polycyclic aromatic hydrocarbons (PAHs), associated 
      exposure estimation, and the role of body mass index (BMI) in their 
      bioaccumulation. A total of 45 breast milk samples were collected from 24 women 
      with BMI > 30 (obese) and 21 women with BMI < 25 (18.5-24.9, normal) from 14 
      different counties surrounding Lubbock in west Texas/New Mexico (age range: 
      18-34 years). Samples were analyzed using high resolution gas chromatography 
      coupled with mass spectrometry. A total of 31/45 (69%) of samples tested positive 
      for PAHs. Phenanthrene was the most frequently detected PAH followed by pyrene 
      and fluoranthene. The mean of individual PAH concentration for all samples ranged 
      from 0 to 25.1 ng/g milk fat; the sum of all means of individual PAHs was 
      146.9 ng/g milk fat. The mean concentration of total PAHs in the BMI > 30 group 
      was 224.8 ng/g milk fat, which was approximately 4 times the mean concentration 
      of total PAHs in the BMI 18.5-24.9 group (57.9 ng/g milk fat). None of the 
      samples from the BMI 18.5-24.9 group contained higher molecular weight (5-6 
      rings) PAHs, while in the BMI >30 group, a total of 11 PAHs including listed EPA 
      priority pollutants were observed. In this study, benzo(b)fluoranthene was found 
      to contribute the highest percentage of carcinogenic PAHs (32.08%), yet it was 
      not detected in any samples from the BMI 18.5-24.9 group. The estimated total 
      PAHs intakes by infants via obese and normal mothers' milk were 1.26 and 0.32 
      (mug/kg/day), which are 0.049 and 0.003 (mug/kg/day) B[a]P equivalent, 
      respectively. These findings suggest that breastfed babies from obese mothers are 
      potentially at higher risk of exposure to carcinogenic PAHs.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Acharya, Narayan
AU  - Acharya N
AD  - The Institute of Environmental and Human Health, Department of Environmental 
      Toxicology, Texas Tech University, Lubbock, TX, USA.
FAU - Gautam, Bibha
AU  - Gautam B
AD  - School of Nursing, Texas Tech University Health Sciences Center, Lubbock, TX, 
      USA.
FAU - Subbiah, Seenivasan
AU  - Subbiah S
AD  - The Institute of Environmental and Human Health, Department of Environmental 
      Toxicology, Texas Tech University, Lubbock, TX, USA.
FAU - Rogge, Mary Madeline
AU  - Rogge MM
AD  - School of Nursing, Texas Tech University Health Sciences Center, Lubbock, TX, 
      USA.
FAU - Anderson, Todd A
AU  - Anderson TA
AD  - The Institute of Environmental and Human Health, Department of Environmental 
      Toxicology, Texas Tech University, Lubbock, TX, USA.
FAU - Gao, Weimin
AU  - Gao W
AD  - Department of Occupational and Environmental Health Sciences, School of Public 
      Health, West Virginia University, Morgantown, WV, USA. Electronic address: 
      weimin.gao@hsc.wvu.edu.
LA  - eng
PT  - Journal Article
DEP - 20190227
PL  - Netherlands
TA  - Sci Total Environ
JT  - The Science of the total environment
JID - 0330500
RN  - 0 (Environmental Pollutants)
RN  - 0 (Polycyclic Aromatic Hydrocarbons)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Body Mass Index
MH  - Breast Feeding
MH  - Environmental Pollutants/*metabolism
MH  - Female
MH  - Humans
MH  - Maternal Exposure/*statistics & numerical data
MH  - Milk, Human/*metabolism
MH  - New Mexico
MH  - Obesity
MH  - Polycyclic Aromatic Hydrocarbons/*metabolism
MH  - Risk Assessment
MH  - Texas
MH  - Young Adult
OTO - NOTNLM
OT  - Breast milk
OT  - Environmental contaminants
OT  - PAHs
OT  - Persistent organic pollutants
EDAT- 2019/03/12 06:00
MHDA- 2019/04/19 06:00
CRDT- 2019/03/12 06:00
PHST- 2019/01/04 00:00 [received]
PHST- 2019/02/21 00:00 [revised]
PHST- 2019/02/24 00:00 [accepted]
PHST- 2019/03/12 06:00 [pubmed]
PHST- 2019/04/19 06:00 [medline]
PHST- 2019/03/12 06:00 [entrez]
AID - S0048-9697(19)30890-3 [pii]
AID - 10.1016/j.scitotenv.2019.02.381 [doi]
PST - ppublish
SO  - Sci Total Environ. 2019 Jun 10;668:658-667. doi: 10.1016/j.scitotenv.2019.02.381. 
      Epub 2019 Feb 27.