PMID- 30856693
OWN - NLM
STAT- MEDLINE
DCOM- 20190703
LR  - 20190703
IS  - 1002-0098 (Print)
IS  - 1002-0098 (Linking)
VI  - 54
IP  - 3
DP  - 2019 Mar 9
TI  - [Expression of matrix metalloproteinase-3 in patients with reheumatoid arthritis 
      and its correlation with chronic periodontitis and rheumatoid arthritis].
PG  - 164-169
LID - 10.3760/cma.j.issn.1002-0098.2019.03.004 [doi]
AB  - Objective: To detect the expression of matrix metalloproteinase-3 (MMP-3) in 
      serum and gingival crevicular fluid in patients with rheumatoid arthritis (RA) 
      and its correlation with chronic periodontitis (CP). Methods: From March 2017 to 
      July 2018, 26 patients with RA and CP [CP+RA group, (54.9+/-6.5) years old, 4 males 
      and 22 females], 22 patients with RA only [RA group, (49.6+/-11.7) years old,5 
      males and 17 females] in the Department of Rheumatology and Immunology, Shengjing 
      Hospital Affiliated to China Medical University, 22 patients with simple CP in 
      the Department of Stomatology, Shengjing Hospital Affiliated to China Medical 
      University [CP group, (51.4+/-12.5) years old, 8 males and 14 females] and 18 
      generally healthy controls in Physical Examination Center of Shengjing Hospital 
      Affiliated to China Medical University [group H, (49.4+/-9.1) years old, 8 males 
      and 10 females] were recruited. There were no significant differences in age and 
      sex ratio amongst 4 groups. Patient's general status, probing depth (PD) , 
      clinical attachment loss (CAL), sulcus bleeding index (SBI), simplified calculus 
      index (CI-S) and simplified debris index (DI-S) were recorded in 4 groups. 
      Samples of serum and gingival crevicular fluid were collected from patients of 
      each group, and the expression levels of MMP-3 in serum and gingival crevicular 
      fluid samples were detected by using enzyme-linked immunosorbent assay. 
      Erythrocyte sedimentation rate, rheumatoid factor, anti-cyclic citrulline peptide 
      antibody and C-reactive protein were detected in the serum of subjects in RA 
      group and CP+RA group. Correlation analysis was conducted between MMP-3 
      expression level and periodontal indices amongst 4 groups. The results were 
      statistically analyzed using the SPSS 20.0 software package. Results: The indices 
      of CAL [(4.12+/-1.13) mm], SBI (2.58+/-0.64) and DI-S (2.65+/-0.69) in CP+RA group were 
      significantly higher than indices of CAL [(3.00+/-0.00) mm], SBI (2.59+/-1.05) and 
      DI-S, (2.36+/-0.49) in CP group (P<0.05); The expression levels of MMP-3 in serum 
      samples of CP+RA group [(1 1645.6+/-6 903.4) mug/L] and CP group [(9 337.0+/-6 719.0) 
      mug/L] were significantly higher than that of RA group [(2 389.9+/-1 320.3) mug/L] 
      and H group [(1 493.5+/-292.1) mug/L] (P<0.05). The expression level of MMP-3 in 
      gingival crevicular fluid samples of CP+RA group [(164.4+/-45.3) mug/L] was 
      significantly higher than that of CP group [(84.6+/-92.5) mug/L], RA group 
      [(49.0+/-18.1) mug/L] and H group [(20.4+/-6.3) mug/L] (P<0.05), respectively. The 
      erythrocyte sedimentation rate, rheumatoid factor and anti-cyclic cirullinated 
      peptide antibodies levels in the CP+RA group were significantly higher than those 
      in the RA group (P<0.05). The expression level of MMP-3 in serum is positively 
      correlated with PD (r=0.45, P=0.04) and the expression level of MMP-3 in gingival 
      crevicular fluid is positively correlated with CAL (r=0.58, P<0.01). Conclusions: 
      The levels of MMP-3 in serum and gingival crevicular fluid of patients with RA 
      and CP were significantly increased. MMP-3 may be associated with the development 
      of CP and RA.
FAU - Zhao, Y
AU  - Zhao Y
AD  - Department of Stomatology, Shengjing Hospital, China Medical University, Shenyang 
      110004, China.
FAU - Jin, Y
AU  - Jin Y
AD  - Department of Stomatology, Shengjing Hospital, China Medical University, Shenyang 
      110004, China.
FAU - Ren, Y S
AU  - Ren YS
AD  - Department of Stomatology, Shengjing Hospital, China Medical University, Shenyang 
      110004, China.
FAU - Song, L M
AU  - Song LM
AD  - Department of Stomatology, Shengjing Hospital, China Medical University, Shenyang 
      110004, China.
FAU - Li, J
AU  - Li J
AD  - Department of Cadres Clinic, School of Stomatology, China Medical University & 
      Liaoning Institute of Dental Research, Shenyang 110002, China.
FAU - Lin, X P
AU  - Lin XP
AD  - Department of Stomatology, Shengjing Hospital, China Medical University, Shenyang 
      110004, China.
LA  - chi
GR  - CSA-Z2015-07/Special Fund of Chinese Stomatological Association/
PT  - Journal Article
PL  - China
TA  - Zhonghua Kou Qiang Yi Xue Za Zhi
JT  - Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese 
      journal of stomatology
JID - 8711066
RN  - EC 3.4.24.17 (MMP3 protein, human)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
RN  - EC 3.4.24.34 (Matrix Metalloproteinase 8)
SB  - IM
MH  - Adult
MH  - *Arthritis, Rheumatoid/complications/metabolism
MH  - China
MH  - *Chronic Periodontitis/complications/metabolism
MH  - Dental Plaque Index
MH  - Female
MH  - Gingival Crevicular Fluid
MH  - Humans
MH  - Male
MH  - *Matrix Metalloproteinase 3/metabolism
MH  - Matrix Metalloproteinase 8
MH  - Middle Aged
MH  - Periodontal Attachment Loss
MH  - Periodontal Index
OTO - NOTNLM
OT  - Arthritis, rheumatoid
OT  - Chronic periodontitis
OT  - Matrix metalloproteinase 3
OT  - Rheumatic immune factors
EDAT- 2019/03/13 06:00
MHDA- 2019/07/04 06:00
CRDT- 2019/03/12 06:00
PHST- 2019/03/12 06:00 [entrez]
PHST- 2019/03/13 06:00 [pubmed]
PHST- 2019/07/04 06:00 [medline]
AID - 10.3760/cma.j.issn.1002-0098.2019.03.004 [doi]
PST - ppublish
SO  - Zhonghua Kou Qiang Yi Xue Za Zhi. 2019 Mar 9;54(3):164-169. doi: 
      10.3760/cma.j.issn.1002-0098.2019.03.004.