PMID- 30857096
OWN - NLM
STAT- MEDLINE
DCOM- 20190321
LR  - 20221207
IS  - 1879-1026 (Electronic)
IS  - 0048-9697 (Linking)
VI  - 627
DP  - 2018 Jun 15
TI  - Oxidative DNA damage mediates the association between urinary metals and 
      prevalence of type 2 diabetes mellitus in Chinese adults.
PG  - 1327-1333
LID - S0048-9697(18)30359-0 [pii]
LID - 10.1016/j.scitotenv.2018.01.317 [doi]
AB  - Previous publications have indicated that some metals are associated with an 
      increased prevalence of type 2 diabetes mellitus (T2DM); however, the mechanisms 
      remain largely unknown. This study aimed to quantify the associations of 
      oxidative DNA damage with urinary metals and prevalence of T2DM among the general 
      population, and further to assess the role of oxidative DNA damage in mediating 
      the association of urinary metals with prevalence of T2DM. Diagnoses of T2DM were 
      performed clinically or by measuring fasting levels of plasma glucose >/=7.0mmol/L. 
      Concentrations of urinary metals and 8-hydroxy-2'-deoxyguanosine (8-OHdG) in 2127 
      participants were measured using inductively coupled plasma-mass spectrometry and 
      high-performance liquid chromatography. Relationships among urinary metals, 
      8-OHdG (a biomarker for oxidative DNA damage), and prevalence of T2DM were 
      analyzed using mediation analysis. After adjusting for covariates, we found that 
      the log-transformed levels of urinary copper, arsenic, selenium, molybdenum, and 
      antimony were positively associated with prevalence of T2DM. Urinary 8-OHdG was 
      not only positively correlated with copper, arsenic, selenium, and antimony in an 
      upwardly trending, dose-responsive manner but was also positively associated with 
      prevalence of T2DM (odds ratio (OR): 1.95; 95% CI: 1.17-3.24). Mediation analysis 
      estimated that urinary 8-OHdG mediated 13.22% and 8.84% of associations between 
      prevalence of T2DM and concentrations of urinary arsenic and antimony, 
      respectively (all P value<0.05). Our findings suggested that urinary arsenic and 
      antimony concentrations were associated with an increased prevalence of T2DM by a 
      mechanism partly involving oxidative DNA damage.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Xiao, Lili
AU  - Xiao L
AD  - Department of Occupational & Environmental Health, School of Public Health, 
      Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 
      Hubei 430030, China; Key Laboratory of Environment and Health, Ministry of 
      Education & Ministry of Environmental Protection, State Key Laboratory of 
      Environmental Health (Incubating), School of Public Health, Tongji Medical 
      College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, 
      China.
FAU - Zhou, Yun
AU  - Zhou Y
AD  - Department of Occupational & Environmental Health, School of Public Health, 
      Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 
      Hubei 430030, China; Key Laboratory of Environment and Health, Ministry of 
      Education & Ministry of Environmental Protection, State Key Laboratory of 
      Environmental Health (Incubating), School of Public Health, Tongji Medical 
      College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, 
      China.
FAU - Ma, Jixuan
AU  - Ma J
AD  - Department of Occupational & Environmental Health, School of Public Health, 
      Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 
      Hubei 430030, China; Key Laboratory of Environment and Health, Ministry of 
      Education & Ministry of Environmental Protection, State Key Laboratory of 
      Environmental Health (Incubating), School of Public Health, Tongji Medical 
      College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, 
      China.
FAU - Sun, Weiwei
AU  - Sun W
AD  - Department of Occupational & Environmental Health, School of Public Health, 
      Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 
      Hubei 430030, China; Key Laboratory of Environment and Health, Ministry of 
      Education & Ministry of Environmental Protection, State Key Laboratory of 
      Environmental Health (Incubating), School of Public Health, Tongji Medical 
      College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, 
      China.
FAU - Cao, Limin
AU  - Cao L
AD  - Department of Occupational & Environmental Health, School of Public Health, 
      Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 
      Hubei 430030, China; Key Laboratory of Environment and Health, Ministry of 
      Education & Ministry of Environmental Protection, State Key Laboratory of 
      Environmental Health (Incubating), School of Public Health, Tongji Medical 
      College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, 
      China.
FAU - Wang, Bin
AU  - Wang B
AD  - Department of Occupational & Environmental Health, School of Public Health, 
      Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 
      Hubei 430030, China; Key Laboratory of Environment and Health, Ministry of 
      Education & Ministry of Environmental Protection, State Key Laboratory of 
      Environmental Health (Incubating), School of Public Health, Tongji Medical 
      College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, 
      China.
FAU - Zhu, Chunmei
AU  - Zhu C
AD  - Department of Occupational & Environmental Health, School of Public Health, 
      Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 
      Hubei 430030, China; Key Laboratory of Environment and Health, Ministry of 
      Education & Ministry of Environmental Protection, State Key Laboratory of 
      Environmental Health (Incubating), School of Public Health, Tongji Medical 
      College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, 
      China.
FAU - Yang, Shijie
AU  - Yang S
AD  - Department of Occupational & Environmental Health, School of Public Health, 
      Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 
      Hubei 430030, China; Key Laboratory of Environment and Health, Ministry of 
      Education & Ministry of Environmental Protection, State Key Laboratory of 
      Environmental Health (Incubating), School of Public Health, Tongji Medical 
      College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, 
      China.
FAU - Wang, Dongming
AU  - Wang D
AD  - Department of Occupational & Environmental Health, School of Public Health, 
      Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 
      Hubei 430030, China; Key Laboratory of Environment and Health, Ministry of 
      Education & Ministry of Environmental Protection, State Key Laboratory of 
      Environmental Health (Incubating), School of Public Health, Tongji Medical 
      College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, 
      China.
FAU - Yuan, Jing
AU  - Yuan J
AD  - Department of Occupational & Environmental Health, School of Public Health, 
      Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 
      Hubei 430030, China; Key Laboratory of Environment and Health, Ministry of 
      Education & Ministry of Environmental Protection, State Key Laboratory of 
      Environmental Health (Incubating), School of Public Health, Tongji Medical 
      College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, 
      China.
FAU - Chen, Weihong
AU  - Chen W
AD  - Department of Occupational & Environmental Health, School of Public Health, 
      Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 
      Hubei 430030, China; Key Laboratory of Environment and Health, Ministry of 
      Education & Ministry of Environmental Protection, State Key Laboratory of 
      Environmental Health (Incubating), School of Public Health, Tongji Medical 
      College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, 
      China. Electronic address: wchen@mails.tjmu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20180207
PL  - Netherlands
TA  - Sci Total Environ
JT  - The Science of the total environment
JID - 0330500
RN  - 0 (Biomarkers)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Metals)
SB  - IM
MH  - Adult
MH  - Asian People
MH  - Biomarkers/metabolism
MH  - DNA Damage
MH  - Diabetes Mellitus, Type 2/*epidemiology/metabolism
MH  - Environmental Exposure/*statistics & numerical data
MH  - Environmental Pollutants/*urine
MH  - Female
MH  - Humans
MH  - Metals/*urine
MH  - Prevalence
OTO - NOTNLM
OT  - 8-OHdG
OT  - Mediation analysis
OT  - T2DM
OT  - Urinary metals
EDAT- 2019/03/13 06:00
MHDA- 2019/03/22 06:00
CRDT- 2019/03/13 06:00
PHST- 2017/10/20 00:00 [received]
PHST- 2018/01/30 00:00 [revised]
PHST- 2018/01/30 00:00 [accepted]
PHST- 2019/03/13 06:00 [entrez]
PHST- 2019/03/13 06:00 [pubmed]
PHST- 2019/03/22 06:00 [medline]
AID - S0048-9697(18)30359-0 [pii]
AID - 10.1016/j.scitotenv.2018.01.317 [doi]
PST - ppublish
SO  - Sci Total Environ. 2018 Jun 15;627:1327-1333. doi: 
      10.1016/j.scitotenv.2018.01.317. Epub 2018 Feb 7.