PMID- 30863277
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1662-4548 (Print)
IS  - 1662-453X (Electronic)
IS  - 1662-453X (Linking)
VI  - 13
DP  - 2019
TI  - Enhanced Global-Brain Functional Connectivity in the Left Superior Frontal Gyrus 
      as a Possible Endophenotype for Schizophrenia.
PG  - 145
LID - 10.3389/fnins.2019.00145 [doi]
LID - 145
AB  - The notion of dysconnectivity in schizophrenia has been put forward for many 
      years and results in substantial attempts to explore altered functional 
      connectivity (FC) within different networks with inconsistent results. Clinical, 
      demographical, and methodological heterogeneity may contribute to the 
      inconsistency. Forty-four patients with first-episode, drug-naive schizophrenia, 
      42 unaffected siblings of schizophrenia patients and 44 healthy controls took 
      part in this study. Global-brain FC (GFC) was employed to analyze the imaging 
      data. Compared with healthy controls, patients with schizophrenia and unaffected 
      siblings shared enhanced GFC in the left superior frontal gyrus (SFG). In 
      addition, patients had increased GFC mainly in the thalamo-cortical network, 
      including the bilateral thalamus, bilateral posterior cingulate cortex 
      (PCC)/precuneus, left superior medial prefrontal cortex (MPFC), right angular 
      gyrus, and right SFG/middle frontal gyrus and decreased GFC in the left 
      ITG/cerebellum Crus I. No other altered GFC values were observed in the siblings 
      group relative to the control group. Further ROC analysis showed that increased 
      GFC in the left SFG could separate the patients or the siblings from the controls 
      with acceptable sensitivities. Our findings suggest that increased GFC in the 
      left SFG may serve as a potential endophenotype for schizophrenia.
FAU - Ding, Yudan
AU  - Ding Y
AD  - Department of Psychiatry, The Second Xiangya Hospital of Central South 
      University, Changsha, China.
FAU - Ou, Yangpan
AU  - Ou Y
AD  - Department of Psychiatry, The Second Xiangya Hospital of Central South 
      University, Changsha, China.
FAU - Su, Qinji
AU  - Su Q
AD  - Mental Health Center, The Second Affiliated Hospital of Guangxi Medical 
      University, Nanning, China.
FAU - Pan, Pan
AU  - Pan P
AD  - Department of Psychiatry, The Second Xiangya Hospital of Central South 
      University, Changsha, China.
FAU - Shan, Xiaoxiao
AU  - Shan X
AD  - Department of Psychiatry, The Second Xiangya Hospital of Central South 
      University, Changsha, China.
FAU - Chen, Jindong
AU  - Chen J
AD  - Department of Psychiatry, The Second Xiangya Hospital of Central South 
      University, Changsha, China.
FAU - Liu, Feng
AU  - Liu F
AD  - Department of Radiology, Tianjin Medical University General Hospital, Tianjin, 
      China.
FAU - Zhang, Zhikun
AU  - Zhang Z
AD  - Mental Health Center, The Second Affiliated Hospital of Guangxi Medical 
      University, Nanning, China.
FAU - Zhao, Jingping
AU  - Zhao J
AD  - Department of Psychiatry, The Second Xiangya Hospital of Central South 
      University, Changsha, China.
FAU - Guo, Wenbin
AU  - Guo W
AD  - Department of Psychiatry, The Second Xiangya Hospital of Central South 
      University, Changsha, China.
LA  - eng
PT  - Journal Article
DEP - 20190226
PL  - Switzerland
TA  - Front Neurosci
JT  - Frontiers in neuroscience
JID - 101478481
PMC - PMC6399149
OTO - NOTNLM
OT  - endophenotype
OT  - functional magnetic resonance imaging
OT  - global-brain functional connectivity
OT  - network
OT  - schizophrenia
EDAT- 2019/03/14 06:00
MHDA- 2019/03/14 06:01
PMCR- 2019/01/01
CRDT- 2019/03/14 06:00
PHST- 2018/10/27 00:00 [received]
PHST- 2019/02/08 00:00 [accepted]
PHST- 2019/03/14 06:00 [entrez]
PHST- 2019/03/14 06:00 [pubmed]
PHST- 2019/03/14 06:01 [medline]
PHST- 2019/01/01 00:00 [pmc-release]
AID - 10.3389/fnins.2019.00145 [doi]
PST - epublish
SO  - Front Neurosci. 2019 Feb 26;13:145. doi: 10.3389/fnins.2019.00145. eCollection 
      2019.