PMID- 30864899
OWN - NLM
STAT- MEDLINE
DCOM- 20200313
LR  - 20211204
IS  - 1473-4877 (Electronic)
IS  - 0300-7995 (Linking)
VI  - 35
IP  - sup1
DP  - 2019 Mar
TI  - Management of a patient with heart failure by sacubitril/valsartan: improvement 
      of functional capacity.
PG  - 7-8
LID - 10.1080/03007995.2019.1576482 [doi]
AB  - The main objectives of the treatment of heart failure (HF) are to improve patient 
      clinical status, functional capacity and quality of life, as well as reducing 
      re-hospitalization rate and mortality. A new compound, consisting of an 
      angiotensin-receptor blocker (ARB) (valsartan) and a neprilysin (NEP) inhibitor 
      (sacubitril), belonging to the newly established class of angiotensin 
      receptor-neprilysin inhibitors (ARNIs) showed marked efficacy, without any 
      relevant safety issue, in the treatment of patients with HF. We report a case of 
      a 48 year old male with HF with reduced ejection fraction (HFrEF) due to 
      hypertensive cardiomyopathy (New York Heart Association [NYHA] class III). 
      Therapy with sacubitril/valsartan was initiated after some years of other 
      treatments, which did not lead to any positive outcome in HF, quality of life and 
      clinical functions. After only 1 month of sacubitril/valsartan therapy, the 
      patient reported a significant improvement in quality of life, and in 6 months 
      his NYHA class switched from III to I.
FAU - Paolini, Carla
AU  - Paolini C
AD  - a Division of Cardiology , West Vicenza General Hospitals , Vicenza , Italy.
FAU - Perrone, Cosimo
AU  - Perrone C
AD  - a Division of Cardiology , West Vicenza General Hospitals , Vicenza , Italy.
FAU - Pellizzari, Cristina Ada
AU  - Pellizzari CA
AD  - a Division of Cardiology , West Vicenza General Hospitals , Vicenza , Italy.
FAU - Randon, Maria Luisa
AU  - Randon ML
AD  - a Division of Cardiology , West Vicenza General Hospitals , Vicenza , Italy.
FAU - Bilato, Claudio
AU  - Bilato C
AD  - a Division of Cardiology , West Vicenza General Hospitals , Vicenza , Italy.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Curr Med Res Opin
JT  - Current medical research and opinion
JID - 0351014
RN  - 0 (Aminobutyrates)
RN  - 0 (Angiotensin Receptor Antagonists)
RN  - 0 (Biphenyl Compounds)
RN  - 0 (Drug Combinations)
RN  - 0 (Tetrazoles)
RN  - 80M03YXJ7I (Valsartan)
RN  - WB8FT61183 (sacubitril and valsartan sodium hydrate drug combination)
SB  - IM
MH  - Aminobutyrates/*therapeutic use
MH  - Angiotensin Receptor Antagonists/*therapeutic use
MH  - Biphenyl Compounds
MH  - Drug Combinations
MH  - Heart Failure/*drug therapy/physiopathology/psychology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Quality of Life
MH  - Stroke Volume
MH  - Tetrazoles/*therapeutic use
MH  - Valsartan
OTO - NOTNLM
OT  - Heart failure
OT  - angiotensin receptor-neprilysin inhibitors
OT  - functional capacity
EDAT- 2019/03/14 06:00
MHDA- 2020/03/14 06:00
CRDT- 2019/03/14 06:00
PHST- 2019/03/14 06:00 [entrez]
PHST- 2019/03/14 06:00 [pubmed]
PHST- 2020/03/14 06:00 [medline]
AID - 10.1080/03007995.2019.1576482 [doi]
PST - ppublish
SO  - Curr Med Res Opin. 2019 Mar;35(sup1):7-8. doi: 10.1080/03007995.2019.1576482.