PMID- 30864900
OWN - NLM
STAT- MEDLINE
DCOM- 20200313
LR  - 20211204
IS  - 1473-4877 (Electronic)
IS  - 0300-7995 (Linking)
VI  - 35
IP  - sup1
DP  - 2019 Mar
TI  - Sacubitril/valsartan improves both functional and echocardiographic parameters in 
      patients with chronic heart failure with reduced ejection fraction.
PG  - 9-12
LID - 10.1080/03007995.2019.1576481 [doi]
AB  - OBJECTIVE: We evaluated the clinical efficacy of sacubitril/valsartan in a group 
      of ambulatory patients with heart failure (HF) with reduced ejection fraction 
      (HFrEF) referred to our HF clinic. METHODS: Patients (n = 29; 72% males; mean age 
      76 years) with HFrEF in New York Heart Association (NYHA) classes II-III were 
      included in the present study. We evaluated clinical as well as echocardiographic 
      parameters (e.g. haemodynamics, such as blood pressure and heart rate, metabolic 
      status, echocardiographic ventricular volumes and ejection fraction [EF]), at 
      baseline and after 6 months of treatment with sacubitril/valsartan. RESULTS: 
      After 6 months of sacubitril/valsartan treatment, several parameters were 
      significantly improved. For example, EF and ventricular volumes (both diastolic 
      and systolic) and atrial dimensions, as well as NYHA functional class (only 1 
      patient was still in NYHA class III) and renal impairment improved. There was no 
      hospitalization for HF or other causes during the 6 month follow-up and no 
      patient died. CONCLUSIONS: Based on our real-life experience, in HFrEF patients 
      with NYHA class II-III, the new angiotensin receptor-neprilysin inhibitor (ARNi) 
      sacubitril/valsartan was effective in improving HF management, both from the 
      clinical and the echocardiographic perspective.
FAU - Cosentino, Eugenio Roberto
AU  - Cosentino ER
AD  - a Cardio-Thoraco-Vascular Department , University Hospital of Bologna , Bologna , 
      Italy.
FAU - Degli Esposti, Daniela
AU  - Degli Esposti D
AD  - a Cardio-Thoraco-Vascular Department , University Hospital of Bologna , Bologna , 
      Italy.
FAU - Miceli, Rinaldo
AU  - Miceli R
AD  - a Cardio-Thoraco-Vascular Department , University Hospital of Bologna , Bologna , 
      Italy.
FAU - Bentivenga, Crescenzio
AU  - Bentivenga C
AD  - a Cardio-Thoraco-Vascular Department , University Hospital of Bologna , Bologna , 
      Italy.
FAU - Landolfo, Matteo
AU  - Landolfo M
AD  - a Cardio-Thoraco-Vascular Department , University Hospital of Bologna , Bologna , 
      Italy.
FAU - Fg Cicero, Arrigo
AU  - Fg Cicero A
AUID- ORCID: 0000-0002-4367-3884
AD  - a Cardio-Thoraco-Vascular Department , University Hospital of Bologna , Bologna , 
      Italy.
FAU - Berardi, Emanuela
AU  - Berardi E
AD  - b UOC Cardiologia Ospedale Civile San Valentino-Montebelluna , Treviso , Italy.
FAU - Spinardi, Luca
AU  - Spinardi L
AD  - a Cardio-Thoraco-Vascular Department , University Hospital of Bologna , Bologna , 
      Italy.
FAU - Magri, Gianluigi
AU  - Magri G
AD  - a Cardio-Thoraco-Vascular Department , University Hospital of Bologna , Bologna , 
      Italy.
FAU - Dugato, Vittorio
AU  - Dugato V
AD  - a Cardio-Thoraco-Vascular Department , University Hospital of Bologna , Bologna , 
      Italy.
FAU - Borghi, Claudio
AU  - Borghi C
AUID- ORCID: 0000-0001-8039-8781
AD  - a Cardio-Thoraco-Vascular Department , University Hospital of Bologna , Bologna , 
      Italy.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Curr Med Res Opin
JT  - Current medical research and opinion
JID - 0351014
RN  - 0 (Aminobutyrates)
RN  - 0 (Angiotensin Receptor Antagonists)
RN  - 0 (Biphenyl Compounds)
RN  - 0 (Drug Combinations)
RN  - 0 (Tetrazoles)
RN  - 80M03YXJ7I (Valsartan)
RN  - WB8FT61183 (sacubitril and valsartan sodium hydrate drug combination)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Aminobutyrates/*therapeutic use
MH  - Angiotensin Receptor Antagonists/*therapeutic use
MH  - Biphenyl Compounds
MH  - Chronic Disease
MH  - Drug Combinations
MH  - Echocardiography/*methods
MH  - Female
MH  - Heart Failure/diagnostic imaging/*drug therapy/physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Stroke Volume/*drug effects
MH  - Tetrazoles/*therapeutic use
MH  - Valsartan
OTO - NOTNLM
OT  - Sacubitril/valsartan
OT  - echocardiography
OT  - heart failure
EDAT- 2019/03/14 06:00
MHDA- 2020/03/14 06:00
CRDT- 2019/03/14 06:00
PHST- 2019/03/14 06:00 [entrez]
PHST- 2019/03/14 06:00 [pubmed]
PHST- 2020/03/14 06:00 [medline]
AID - 10.1080/03007995.2019.1576481 [doi]
PST - ppublish
SO  - Curr Med Res Opin. 2019 Mar;35(sup1):9-12. doi: 10.1080/03007995.2019.1576481.