PMID- 30866076
OWN - NLM
STAT- MEDLINE
DCOM- 20200602
LR  - 20200602
IS  - 1096-9071 (Electronic)
IS  - 0146-6615 (Linking)
VI  - 91
IP  - 8
DP  - 2019 Aug
TI  - Rhinoviruses in infancy and risk of immunoglobulin E sensitization.
PG  - 1470-1478
LID - 10.1002/jmv.25455 [doi]
AB  - Previous data about the role of viruses in the development of allergic 
      immunoglobulin E (IgE) sensitization are contradictory. The aim of this study was 
      to determine the possible associations between exposure to different viruses 
      (rhinovirus, enterovirus, norovirus, and parechovirus) during the first year of 
      life and IgE sensitization. Viruses were analyzed from stool samples collected 
      monthly from infants participating in a prospective birth cohort study. From that 
      study, 244 IgE sensitized case children and 244 nonsensitized control children 
      were identified based on their allergen-specific IgE antibody levels at the age 
      of 6, 18, and 36 months. Stool samples (n = 4576) from the case and control 
      children were screened for the presence of rhinovirus, enterovirus, norovirus, 
      and parechovirus RNA by reverse transcription quantitative polymerase chain 
      reaction. The study showed that rhinovirus was the most prevalent virus detected, 
      present in 921 (20%) samples. None of the viruses were associated with IgE 
      sensitization in the full cohort but after stratifying by sex, the number of 
      rhinovirus positive samples was inversely associated with IgE sensitization in 
      boys (odds ratio [OR]: 0.81; 95% confidence interval [CI]: 0.69-0.94; P = 0.006). 
      There was also a temporal relation between rhinoviruses and IgE sensitization, as 
      rhinovirus exposure during the first 6 months of life was associated with a 
      reduced risk of subsequent IgE sensitization in boys (OR: 0.76; 95% CI: 0.6-0.94; 
      P = 0.016). In conclusion, early exposure to rhinoviruses was inversely 
      associated with IgE sensitization but this protective association was restricted 
      to boys.
CI  - (c) 2019 Wiley Periodicals, Inc.
FAU - Korhonen, Laura
AU  - Korhonen L
AUID- ORCID: 0000-0002-5566-8054
AD  - Department of Virology, Faculty of Medical Sciences and Biotechnology, Tampere 
      University, Tampere, Finland.
AD  - Department of Dermatology, Tampere University Hospital, Tampere, Finland.
AD  - Allergy Centre, Tampere University Hospital, Tampere, Finland.
FAU - Oikarinen, Sami
AU  - Oikarinen S
AD  - Department of Virology, Faculty of Medical Sciences and Biotechnology, Tampere 
      University, Tampere, Finland.
AD  - Department of Clinical Microbiology, Fimlab Laboratories Ltd, Tampere, Finland.
FAU - Lehtonen, Jussi
AU  - Lehtonen J
AD  - Department of Virology, Faculty of Medical Sciences and Biotechnology, Tampere 
      University, Tampere, Finland.
FAU - Mustonen, Neea
AU  - Mustonen N
AD  - Children's Hospital, University of Helsinki and Helsinki University Hospital, 
      Helsinki, Finland.
AD  - Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, 
      Finland.
FAU - Tyni, Iiris
AU  - Tyni I
AD  - Department of Virology, Faculty of Medical Sciences and Biotechnology, Tampere 
      University, Tampere, Finland.
FAU - Niemela, Onni
AU  - Niemela O
AD  - Department of Laboratory Medicine and Medical Research Unit, Seinajoki Central 
      Hospital and University of Tampere, Seinajoki, Finland.
FAU - Honkanen, Hanna
AU  - Honkanen H
AD  - Department of Virology, Faculty of Medical Sciences and Biotechnology, Tampere 
      University, Tampere, Finland.
FAU - Huhtala, Heini
AU  - Huhtala H
AD  - Faculty of Social Sciences, Tampere University, Tampere, Finland.
FAU - Ilonen, Jorma
AU  - Ilonen J
AD  - Immunogenetics Laboratory, University of Turku and Turku University Hospital, 
      Turku, Finland.
FAU - Hamalainen, Anu-Maaria
AU  - Hamalainen AM
AD  - Department of Pediatrics, Jorvi Hospital, Helsinki University Hospital, Espoo, 
      Finland.
FAU - Peet, Aleksandr
AU  - Peet A
AD  - Department of Pediatrics, University of Tartu, Tartu, Estonia.
AD  - Children's Clinic of Tartu University Hospital, Tartu, Estonia.
FAU - Tillmann, Vallo
AU  - Tillmann V
AD  - Department of Pediatrics, University of Tartu, Tartu, Estonia.
AD  - Children's Clinic of Tartu University Hospital, Tartu, Estonia.
FAU - Siljander, Heli
AU  - Siljander H
AD  - Children's Hospital, University of Helsinki and Helsinki University Hospital, 
      Helsinki, Finland.
AD  - Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, 
      Finland.
FAU - Knip, Mikael
AU  - Knip M
AD  - Children's Hospital, University of Helsinki and Helsinki University Hospital, 
      Helsinki, Finland.
AD  - Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, 
      Finland.
AD  - Folkhalsan Research Center, Helsinki, Finland.
AD  - Department of Pediatrics, Tampere University Hospital, Tampere, Finland.
FAU - Lonnrot, Maria
AU  - Lonnrot M
AD  - Department of Virology, Faculty of Medical Sciences and Biotechnology, Tampere 
      University, Tampere, Finland.
AD  - Department of Dermatology, Tampere University Hospital, Tampere, Finland.
AD  - Allergy Centre, Tampere University Hospital, Tampere, Finland.
FAU - Hyoty, Heikki
AU  - Hyoty H
AD  - Department of Virology, Faculty of Medical Sciences and Biotechnology, Tampere 
      University, Tampere, Finland.
AD  - Department of Clinical Microbiology, Fimlab Laboratories Ltd, Tampere, Finland.
CN  - DIABIMMUNE Study Group
LA  - eng
GR  - Tampere Tuberculosis Foundation/International
GR  - PUT 1382/Estonia Research Council/International
GR  - 250114 2012-2017/Suomen Akatemia/International
GR  - 132362-2009/Suomen Akatemia/International
GR  - 129448-2008/Suomen Akatemia/International
GR  - Sigrid Juselius Foundation/International
GR  - The National Technology Agency in Finland (TEKES)/International
GR  - Orion-Farmos Research Foundation/International
GR  - Paivikki ja Sakari Sohlbergin Saatio/International
GR  - 202063/European Union Seventh Framework Program FP7/2007-2013/International
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190325
PL  - United States
TA  - J Med Virol
JT  - Journal of medical virology
JID - 7705876
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Age Factors
MH  - Child, Preschool
MH  - *Disease Susceptibility
MH  - Enterovirus/isolation & purification
MH  - Feces/virology
MH  - Female
MH  - Humans
MH  - Hypersensitivity/*epidemiology
MH  - Immunoglobulin E/*blood
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Norovirus/isolation & purification
MH  - Parechovirus/isolation & purification
MH  - Picornaviridae Infections/*complications
MH  - Prospective Studies
MH  - Rhinovirus/*immunology/isolation & purification
MH  - Risk
MH  - Sex Factors
OTO - NOTNLM
OT  - allergy
OT  - atopy
OT  - sex
OT  - stool
OT  - virus
EDAT- 2019/03/14 06:00
MHDA- 2020/06/03 06:00
CRDT- 2019/03/14 06:00
PHST- 2018/11/26 00:00 [received]
PHST- 2019/02/20 00:00 [revised]
PHST- 2019/03/09 00:00 [accepted]
PHST- 2019/03/14 06:00 [pubmed]
PHST- 2020/06/03 06:00 [medline]
PHST- 2019/03/14 06:00 [entrez]
AID - 10.1002/jmv.25455 [doi]
PST - ppublish
SO  - J Med Virol. 2019 Aug;91(8):1470-1478. doi: 10.1002/jmv.25455. Epub 2019 Mar 25.