PMID- 30866136
OWN - NLM
STAT- MEDLINE
DCOM- 20191212
LR  - 20200108
IS  - 1399-3062 (Electronic)
IS  - 1398-2273 (Linking)
VI  - 21
IP  - 4
DP  - 2019 Aug
TI  - Impact of human leukocyte antigen and calculated panel reactive antibody on BK 
      viremia in kidney transplant recipients: A single-center experience and 
      literature review.
PG  - e13071
LID - 10.1111/tid.13071 [doi]
AB  - BACKGROUND: The aim of this retrospective analysis was to investigate the effect 
      of human leukocyte antigen (HLA) and calculated panel reactive antibody (cPRA) on 
      BK virus activation as evidenced by BK viremia (BKV). PATIENTS AND METHODS: At 
      our institution, 649 kidney transplant patients were screened for BKV from 2009 
      to 2017. Patients were considered to have BKV if they had >10 000 copies/mL of BK 
      DNA in their blood. Donor and recipient HLA and cPRA, demographic, clinical and 
      laboratory data, as well as immunosuppressive medications were collected. 
      RESULTS: We identified 122 BK positive and 527 BK negative patients. Only 25% of 
      the patients had cPRA of 20% or more, and 64% had more than three HLA-A, -B, and 
      -DR mismatches. In both univariate and multivariate analyses, male gender, age, 
      and maintenance of steroid therapy significantly increased the risk of BKV 
      (P = 0.005, 0.005 and <0.001, respectively). The degree of cPRA and the 
      individual HLA allele and HLA allele matching did not significantly affect BKV. 
      CONCLUSION: Neither the degree of HLA mismatching nor cPRA appears to affect BKV. 
      Moreover, no specific HLA allele, HLA allele matching, or cPRA were associated 
      with BKV.
CI  - (c) 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - El-Husseini, Amr
AU  - El-Husseini A
AUID- ORCID: 0000-0001-9072-5029
AD  - Division of Nephrology and Transplant Program, University of Kentucky, Lexington, 
      Kentucky.
FAU - Hassan, Waleed
AU  - Hassan W
AD  - Division of Nephrology and Transplant Program, University of Kentucky, Lexington, 
      Kentucky.
FAU - Yaseen, Maria
AU  - Yaseen M
AD  - Division of Nephrology and Transplant Program, University of Kentucky, Lexington, 
      Kentucky.
FAU - Suleiman, Belal
AU  - Suleiman B
AD  - Division of Nephrology and Transplant Program, University of Kentucky, Lexington, 
      Kentucky.
FAU - Saleh, Sherif
AU  - Saleh S
AD  - Division of Nephrology and Transplant Program, University of Kentucky, Lexington, 
      Kentucky.
FAU - Malik, Omar
AU  - Malik O
AD  - Division of Nephrology and Transplant Program, University of Kentucky, Lexington, 
      Kentucky.
FAU - Ashqar, Hasan
AU  - Ashqar H
AD  - Division of Nephrology and Transplant Program, University of Kentucky, Lexington, 
      Kentucky.
FAU - Maibam, Amita
AU  - Maibam A
AD  - Division of Nephrology and Transplant Program, University of Kentucky, Lexington, 
      Kentucky.
FAU - Mei, Xiaonan
AU  - Mei X
AD  - Division of Nephrology and Transplant Program, University of Kentucky, Lexington, 
      Kentucky.
FAU - Castellanos, Ana L
AU  - Castellanos AL
AD  - Division of Nephrology and Transplant Program, University of Kentucky, Lexington, 
      Kentucky.
FAU - Cornea, Virgilius
AU  - Cornea V
AD  - Department of Surgical Pathology, University of Kentucky, Lexington, Kentucky.
FAU - Gedaly, Roberto
AU  - Gedaly R
AD  - Division of Nephrology and Transplant Program, University of Kentucky, Lexington, 
      Kentucky.
FAU - Waid, Thomas
AU  - Waid T
AD  - Division of Nephrology and Transplant Program, University of Kentucky, Lexington, 
      Kentucky.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20190518
PL  - Denmark
TA  - Transpl Infect Dis
JT  - Transplant infectious disease : an official journal of the Transplantation 
      Society
JID - 100883688
RN  - 0 (DNA, Viral)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adult
MH  - Aged
MH  - BK Virus/*immunology
MH  - DNA, Viral
MH  - Electronic Health Records
MH  - Female
MH  - HLA Antigens/*immunology
MH  - Humans
MH  - Kidney/pathology/virology
MH  - Male
MH  - Middle Aged
MH  - Polyomavirus Infections/*immunology
MH  - Retrospective Studies
MH  - *Transplant Recipients
MH  - Tumor Virus Infections/*immunology
MH  - Viremia/*immunology
OTO - NOTNLM
OT  - BK viremia
OT  - calculated panel reactive antibody
OT  - human leukocyte antigen
OT  - immunology
OT  - renal transplantation
EDAT- 2019/03/14 06:00
MHDA- 2019/12/18 06:00
CRDT- 2019/03/14 06:00
PHST- 2018/10/08 00:00 [received]
PHST- 2019/01/25 00:00 [revised]
PHST- 2019/02/15 00:00 [accepted]
PHST- 2019/03/14 06:00 [pubmed]
PHST- 2019/12/18 06:00 [medline]
PHST- 2019/03/14 06:00 [entrez]
AID - 10.1111/tid.13071 [doi]
PST - ppublish
SO  - Transpl Infect Dis. 2019 Aug;21(4):e13071. doi: 10.1111/tid.13071. Epub 2019 May 
      18.