PMID- 3086676
OWN - NLM
STAT- MEDLINE
DCOM- 19860714
LR  - 20190820
IS  - 0385-5600 (Print)
IS  - 0385-5600 (Linking)
VI  - 30
IP  - 2
DP  - 1986
TI  - The production of a cytotoxic factor by mouse peritoneal macrophages and 
      macrophage hybridomas treated with various stimulating agents.
PG  - 143-54
AB  - Murine peritoneal macrophages elicited with a streptococcal preparation, OK-432, 
      produced as much of a cytotoxic factor after stimulation with lipopolysaccharide 
      (LPS) as BCG-elicited macrophages did. Proteose peptone-elicited macrophages 
      produced a very small amount, if any, of the factor, and resident peritoneal 
      macrophages did not release it at all even after LPS-stimulation. A newly 
      established macrophage hybridoma, D/O-3.3, produced the factor after 
      LPS-stimulation, but another hybridoma, D/O-3.2, did not. Experiments using these 
      peritoneal macrophages and macrophage hybridomas demonstrated that macrophages 
      can be divided into three subpopulations with regard to stages of activation for 
      production of the cytotoxic factor. The first is fully activated macrophages 
      which produce the factor after stimulation with LPS or MAF-C alone, the second is 
      partially activated macrophages which produce the factor only after stimulation 
      with a combination of recombinant interferon-gamma (rIFN-gamma) and LPS or 
      rIFN-gamma and macrophage activating factor for cytotoxicity (MAF-C), and the 
      third is nonactivated macrophages which cannot produce the factor at all.
FAU - Takeda, Y
AU  - Takeda Y
FAU - Higuchi, M
AU  - Higuchi M
FAU - Sugimoto, M
AU  - Sugimoto M
FAU - Shimoda, O
AU  - Shimoda O
FAU - Woo, H J
AU  - Woo HJ
FAU - Shimada, S
AU  - Shimada S
FAU - Osawa, T
AU  - Osawa T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Australia
TA  - Microbiol Immunol
JT  - Microbiology and immunology
JID - 7703966
RN  - 0 (Cytotoxins)
RN  - 0 (Glycoproteins)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Lymphokines)
RN  - 0 (Macrophage-Activating Factors)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 39325-01-4 (Picibanil)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Animals
MH  - Cell Line
MH  - Cytotoxicity, Immunologic
MH  - Cytotoxins/*biosynthesis
MH  - Glycoproteins/biosynthesis
MH  - Hybridomas/metabolism
MH  - Interferon-gamma/pharmacology
MH  - Lipopolysaccharides/pharmacology
MH  - Lymphokines/pharmacology
MH  - Macrophage Activation
MH  - Macrophage-Activating Factors
MH  - Macrophages/immunology/*metabolism
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Picibanil/pharmacology
MH  - Tumor Necrosis Factor-alpha
EDAT- 1986/01/01 00:00
MHDA- 1986/01/01 00:01
CRDT- 1986/01/01 00:00
PHST- 1986/01/01 00:00 [pubmed]
PHST- 1986/01/01 00:01 [medline]
PHST- 1986/01/01 00:00 [entrez]
AID - 10.1111/j.1348-0421.1986.tb00929.x [doi]
PST - ppublish
SO  - Microbiol Immunol. 1986;30(2):143-54. doi: 10.1111/j.1348-0421.1986.tb00929.x.