PMID- 30866835 OWN - NLM STAT- MEDLINE DCOM- 20190426 LR - 20200225 IS - 1471-2334 (Electronic) IS - 1471-2334 (Linking) VI - 19 IP - 1 DP - 2019 Mar 12 TI - Chikungunya virus infection in Indonesia: a systematic review and evolutionary analysis. PG - 243 LID - 10.1186/s12879-019-3857-y [doi] LID - 243 AB - BACKGROUND: Despite the high number of chikungunya cases in Indonesia in recent years, comprehensive epidemiological data are lacking. The systematic review was undertaken to provide data on incidence, the seroprevalence of anti-Chikungunya virus (CHIKV) IgM and IgG antibodies, mortality, the genotypes of circulating CHIKV and travel-related cases of chikungunya in the country. In addition, a phylogenetic and evolutionary analysis of Indonesian CHIKV was conducted. METHODS: A systematic review was conducted to identify eligible studies from EMBASE, MEDLINE, PubMed and Web of Science as of October 16th 2017. Studies describing the incidence, seroprevalence of IgM and IgG, mortality, genotypes and travel-associated chikungunya were systematically reviewed. The maximum likelihood phylogenetic and evolutionary rate was estimated using Randomized Axelerated Maximum Likelihood (RAxML), and the Bayesian Markov chain Monte Carlo (MCMC) method identified the Time to Most Recent Common Ancestors (TMRCA) of Indonesian CHIKV. The systematic review was registered in the PROSPERO database (CRD42017078205). RESULTS: Chikungunya incidence ranged between 0.16-36.2 cases per 100,000 person-year. Overall, the median seroprevalence of anti-CHIKV IgM antibodies in both outbreak and non-outbreak scenarios was 13.3% (17.7 and 7.3% for outbreak and non-outbreak events, respectively). The median seroprevalence of IgG antibodies in both outbreak and non-outbreak settings was 18.5% (range 0.0-73.1%). There were 130 Indonesian CHIKV sequences available, of which 120 (92.3%) were of the Asian genotype and 10 (7.7%) belonged to the East/Central/South African (ECSA) genotype. The ECSA genotype was first isolated in Indonesia in 2008 and was continually sampled until 2011. All ECSA viruses sampled in Indonesia appear to be closely related to viruses that caused massive outbreaks in Southeast Asia countries during the same period. Massive nationwide chikungunya outbreaks in Indonesia were reported during 2009-2010 with a total of 137,655 cases. Our spatio-temporal, phylogenetic and evolutionary data suggest that these outbreaks were likely associated with the introduction of the ECSA genotype of CHIKV to Indonesia. CONCLUSIONS: Although no deaths have been recorded, the seroprevalence of anti-CHIKV IgM and IgG in the Indonesian population have been relatively high in recent years following re-emergence in early 2001. There is sufficient evidence to suggest that the introduction of ECSA into Indonesia was likely associated with massive chikungunya outbreaks during 2009-2010. FAU - Harapan, Harapan AU - Harapan H AUID- ORCID: 0000-0001-7630-8413 AD - Medical Research Unit, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia. harapan@unsyiah.ac.id. AD - School of Biomedical Sciences, University of Western Australia, 35 Stirling Highway, Crawley, 6009, Australia. harapan@unsyiah.ac.id. FAU - Michie, Alice AU - Michie A AD - School of Biomedical Sciences, University of Western Australia, 35 Stirling Highway, Crawley, 6009, Australia. FAU - Mudatsir, Mudatsir AU - Mudatsir M AD - Medical Research Unit, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia. mudatsir@unsyiah.ac.id. AD - Department of Microbiology, School of Medicine, Universitas Syiah Kuala, Jl. T. Tanoeh Abe, Darussalam, Banda Aceh, 23111, Indonesia. mudatsir@unsyiah.ac.id. FAU - Nusa, Roy AU - Nusa R AD - Vector Borne Disease Control, Research and Development Council, Ministry of Health of the Republic of Indonesia, Jakarta, Indonesia. FAU - Yohan, Benediktus AU - Yohan B AD - Eijkman Institute for Molecular Biology, Jakarta, Indonesia. FAU - Wagner, Abram Luther AU - Wagner AL AD - Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA. FAU - Sasmono, R Tedjo AU - Sasmono RT AD - Eijkman Institute for Molecular Biology, Jakarta, Indonesia. FAU - Imrie, Allison AU - Imrie A AD - School of Biomedical Sciences, University of Western Australia, 35 Stirling Highway, Crawley, 6009, Australia. allison.imrie@uwa.edu.au. AD - Pathwest Laboratory Medicine Western Australia, Nedlands, Western Australia, Australia. allison.imrie@uwa.edu.au. LA - eng GR - ST000DMX2/Department of Foreign Affairs and Trade, Australian Government/ GR - F51416/The University of Western Australia/ GR - N/A/National Health and Medical Research Council/ PT - Journal Article PT - Systematic Review DEP - 20190312 PL - England TA - BMC Infect Dis JT - BMC infectious diseases JID - 100968551 SB - IM MH - *Chikungunya Fever/epidemiology/mortality/virology MH - *Chikungunya virus MH - Humans MH - Indonesia/epidemiology MH - Phylogeny MH - Seroepidemiologic Studies PMC - PMC6417237 OTO - NOTNLM OT - Chikungunya OT - Chikungunya virus OT - ECSA genotype OT - Indonesia OT - Systematic review COIS- ETHICS APPROVAL AND CONSENT TO PARTICIPATE: Not applicable. CONSENT FOR PUBLICATION: Not applicable. COMPETING INTERESTS: The authors declare that they have no competing interests. PUBLISHER'S NOTE: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. EDAT- 2019/03/15 06:00 MHDA- 2019/04/27 06:00 PMCR- 2019/03/12 CRDT- 2019/03/15 06:00 PHST- 2018/12/21 00:00 [received] PHST- 2019/02/27 00:00 [accepted] PHST- 2019/03/15 06:00 [entrez] PHST- 2019/03/15 06:00 [pubmed] PHST- 2019/04/27 06:00 [medline] PHST- 2019/03/12 00:00 [pmc-release] AID - 10.1186/s12879-019-3857-y [pii] AID - 3857 [pii] AID - 10.1186/s12879-019-3857-y [doi] PST - epublish SO - BMC Infect Dis. 2019 Mar 12;19(1):243. doi: 10.1186/s12879-019-3857-y.