PMID- 30867693
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 17
IP  - 3
DP  - 2019 Mar
TI  - Effect of baicalin on renal function in patients with diabetic nephropathy and 
      its therapeutic mechanism.
PG  - 2071-2076
LID - 10.3892/etm.2019.7181 [doi]
AB  - The present study observed the effect of baicalin on blood glucose and renal 
      function in patients with diabetic nephropathy and explored its mechanism of 
      action. A total of 95 patients diagnosed with diabetic nephropathy by clinical 
      and laboratory examinations were selected and randomly divided into a control and 
      treatment group. The control group included 45 patients who were treated with 
      routine symptomatic treatment. The remaining 50 patients in the treatment group 
      received baicalin, in addition to routine symptomatic treatment. The treatment 
      course was 6 months. Following this, the changes of indicators such as fasting 
      plasma glucose (FPG), glycosylated hemoglobin (HBA1c), aldose reductase (AR) 
      activity, 24-h urinary microalbumin, urinary beta2-microglobulin (beta2-MG) and urinary 
      albumin excretion rate (UAER) were compared before and after treatment; at the 
      same time, the variations of indexes, including superoxide dismutase (SOD), 
      glutathione peroxidase (GSH-px), nuclear factor kappa-light-chain-enhancer of 
      activated B cells (NF-kappaB), transforming growth factor-beta1 (TGF-beta1) and vascular 
      endothelial growth factor (VEGF) were detected. Compared with those in the 
      control group, baicalin had little effect on the treatment group's FPG and HBA1c, 
      but it clearly reduced the AR activity and the difference was significant 
      (P<0.05). Baicalin visibly decreased the 24-h urinary microalbumin, urinary beta2-MG 
      and UAER (P<0.05) and had notable effect on improving renal function. Following 
      treatment, compared with those in the control group, baicalin distinctly 
      increased the levels of SOD and GSH-px (P<0.05) and decreased the content of 
      NF-kappaB and VEGF (P<0.05), however, its impact on the expression of TGF-beta1 was not 
      statistically significant (P>0.05). The results showed that baicalin may improve 
      the renal function in patients with diabetic nephropathy and delay the 
      progression of diabetic nephropathy through various ways, including 
      anti-inflammation and anti-oxidation.
FAU - Yang, Mingzheng
AU  - Yang M
AD  - Department of Nephrology, Qingpu Branch of Zhongshan Hospital Affiliated to Fudan 
      University, Shanghai 201700, P.R. China.
FAU - Kan, Lin
AU  - Kan L
AD  - Department of Clinical Laboratory, Qingpu Branch of Zhongshan Hospital Affiliated 
      to Fudan University, Shanghai 201700, P.R. China.
FAU - Wu, Lianye
AU  - Wu L
AD  - Department of Nephrology, Qingpu Branch of Zhongshan Hospital Affiliated to Fudan 
      University, Shanghai 201700, P.R. China.
FAU - Zhu, Yingchun
AU  - Zhu Y
AD  - Department of Nephrology, Qingpu Branch of Zhongshan Hospital Affiliated to Fudan 
      University, Shanghai 201700, P.R. China.
FAU - Wang, Qing
AU  - Wang Q
AD  - Department of Nephrology, Qingpu Branch of Zhongshan Hospital Affiliated to Fudan 
      University, Shanghai 201700, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20190117
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC6396004
OTO - NOTNLM
OT  - baicalin
OT  - diabetic nephropathy
OT  - renal function
OT  - therapeutic mechanism
EDAT- 2019/03/15 06:00
MHDA- 2019/03/15 06:01
PMCR- 2019/01/17
CRDT- 2019/03/15 06:00
PHST- 2017/09/17 00:00 [received]
PHST- 2018/11/28 00:00 [accepted]
PHST- 2019/03/15 06:00 [entrez]
PHST- 2019/03/15 06:00 [pubmed]
PHST- 2019/03/15 06:01 [medline]
PHST- 2019/01/17 00:00 [pmc-release]
AID - ETM-0-0-7181 [pii]
AID - 10.3892/etm.2019.7181 [doi]
PST - ppublish
SO  - Exp Ther Med. 2019 Mar;17(3):2071-2076. doi: 10.3892/etm.2019.7181. Epub 2019 Jan 
      17.