PMID- 30870631
OWN - NLM
STAT- MEDLINE
DCOM- 20190605
LR  - 20190605
IS  - 1879-1298 (Electronic)
IS  - 0045-6535 (Linking)
VI  - 225
DP  - 2019 Jun
TI  - Biochemical and molecular biomarkers in integument biopsies of free-ranging 
      coastal bottlenose dolphins from southern Brazil.
PG  - 139-149
LID - S0045-6535(19)30403-5 [pii]
LID - 10.1016/j.chemosphere.2019.02.179 [doi]
AB  - Adverse effects of exposure to persistent organic pollutants (POPs) threaten the 
      maintenance of odontocete populations. In southern Brazil, coastal bottlenose 
      dolphins from the Laguna Estuarine System (LES) and Patos Lagoon Estuary (PLE) 
      were sampled using remote biopsies during the winter and summer months. Levels of 
      bioaccumulated POPs were measured in the blubber. The activities of glutathione 
      S-transferase (GST), glutathione reductase (GR), glutathione peroxidase (GPx), 
      and superoxide dismutase (SOD) were also quantified, as were the mRNA transcript 
      levels of aryl hydrocarbon receptor (AhR), AhR nuclear translocator (ARNT), 
      cytochrome P450 1A1-like (CYP1A1), metallothionein 2A (MT2A), GST-pi, GPx-4, GR, 
      interleukin 1 alpha (IL-1alpha), and major histocompatibility complex II (MHCII) in 
      the skin. In general, levels of POPs were similar among sites, sexes, ages and 
      seasons. For most animals, total polychlorinated biphenyl (SigmaPCBs) levels were 
      above the threshold level have physiological effects and pose risks to cetaceans. 
      The best-fitting generalized linear models (GLMs) found significant associations 
      between GR, IL-1alpha and GPx-4 transcript levels, SOD and GST activities, and total 
      polybrominated diphenyl ether (SigmaPBDEs) and pesticide levels. GLMs and 
      Kruskal-Wallis analyses also indicated that there were higher transcript levels 
      for most genes and lower GST activity in the winter. These results reinforce the 
      need to consider the influence of environmental traits on biomarker values in 
      wildlife assessments.
CI  - Copyright (c) 2019 Elsevier Ltd. All rights reserved.
FAU - Righetti, Barbara Pacheco Harrison
AU  - Righetti BPH
AD  - Laboratorio de Biomarcadores de Contaminacao Aquatica e Imunoquimica, 
      Departamento de Bioquimica, Universidade Federal de Santa Catarina, 
      Florianopolis, Brazil.
FAU - Mattos, Jaco Joaquim
AU  - Mattos JJ
AD  - Laboratorio de Biomarcadores de Contaminacao Aquatica e Imunoquimica, 
      Departamento de Bioquimica, Universidade Federal de Santa Catarina, 
      Florianopolis, Brazil.
FAU - Siebert, Marilia Nardelli
AU  - Siebert MN
AD  - Laboratorio de Biomarcadores de Contaminacao Aquatica e Imunoquimica, 
      Departamento de Bioquimica, Universidade Federal de Santa Catarina, 
      Florianopolis, Brazil.
FAU - Daura-Jorge, Fabio Goncalves
AU  - Daura-Jorge FG
AD  - Laboratorio de Mamiferos Aquaticos, Departamento de Ecologia e Zoologia, 
      Universidade Federal de Santa Catarina, Florianopolis, Brazil.
FAU - Bezamat, Carolina
AU  - Bezamat C
AD  - Laboratorio de Mamiferos Aquaticos, Departamento de Ecologia e Zoologia, 
      Universidade Federal de Santa Catarina, Florianopolis, Brazil.
FAU - Fruet, Pedro Friedrich
AU  - Fruet PF
AD  - Museu Oceanografico, Universidade Federal de Rio Grande, Rio Grande, Brazil; 
      Kaosa, Rio Grade, Brazil; Centro Nacional de Pesquisa e Conservacao de Mamiferos 
      Aquaticos - ICMBio/CMA, Santos, SP, Brazil.
FAU - Genoves, Rodrigo Cezar
AU  - Genoves RC
AD  - Museu Oceanografico, Universidade Federal de Rio Grande, Rio Grande, Brazil; 
      Kaosa, Rio Grade, Brazil.
FAU - Taniguchi, Satie
AU  - Taniguchi S
AD  - Laboratorio de Quimica Organica, Universidade de Sao Paulo, Sao Paulo, Brazil.
FAU - da Silva, Josilene
AU  - da Silva J
AD  - Laboratorio de Quimica Organica, Universidade de Sao Paulo, Sao Paulo, Brazil.
FAU - Montone, Rosalinda Carmela
AU  - Montone RC
AD  - Laboratorio de Quimica Organica, Universidade de Sao Paulo, Sao Paulo, Brazil.
FAU - Simoes-Lopes, Paulo Cesar de Azevedo
AU  - Simoes-Lopes PCA
AD  - Laboratorio de Mamiferos Aquaticos, Departamento de Ecologia e Zoologia, 
      Universidade Federal de Santa Catarina, Florianopolis, Brazil.
FAU - Bainy, Afonso Celso Dias
AU  - Bainy ACD
AD  - Laboratorio de Biomarcadores de Contaminacao Aquatica e Imunoquimica, 
      Departamento de Bioquimica, Universidade Federal de Santa Catarina, 
      Florianopolis, Brazil.
FAU - Luchmann, Karim Hahn
AU  - Luchmann KH
AD  - Departamento de Educacao Cientifica e Tecnologica, Universidade do Estado de 
      Santa Catarina, Florianopolis, Brazil. Electronic address: 
      karim.luchmann@udesc.br.
LA  - eng
PT  - Journal Article
DEP - 20190302
PL  - England
TA  - Chemosphere
JT  - Chemosphere
JID - 0320657
RN  - 0 (Biomarkers)
RN  - 0 (RNA, Messenger)
RN  - 0 (Water Pollutants, Chemical)
SB  - IM
MH  - Adipose Tissue/drug effects/metabolism
MH  - Animals
MH  - Biomarkers/metabolism
MH  - Biopsy
MH  - Bottle-Nosed Dolphin/*genetics/*metabolism
MH  - Brazil
MH  - Environmental Monitoring/*methods
MH  - Gene Expression Regulation, Enzymologic/drug effects
MH  - RNA, Messenger/genetics/metabolism
MH  - Water Pollutants, Chemical/toxicity
OTO - NOTNLM
OT  - Biomarker response
OT  - Bottlenose dolphins
OT  - Organic contaminants
EDAT- 2019/03/15 06:00
MHDA- 2019/06/06 06:00
CRDT- 2019/03/15 06:00
PHST- 2018/11/13 00:00 [received]
PHST- 2019/02/24 00:00 [revised]
PHST- 2019/02/25 00:00 [accepted]
PHST- 2019/03/15 06:00 [pubmed]
PHST- 2019/06/06 06:00 [medline]
PHST- 2019/03/15 06:00 [entrez]
AID - S0045-6535(19)30403-5 [pii]
AID - 10.1016/j.chemosphere.2019.02.179 [doi]
PST - ppublish
SO  - Chemosphere. 2019 Jun;225:139-149. doi: 10.1016/j.chemosphere.2019.02.179. Epub 
      2019 Mar 2.