PMID- 30871339
OWN - NLM
STAT- MEDLINE
DCOM- 20200224
LR  - 20200224
IS  - 1535-4970 (Electronic)
IS  - 1073-449X (Linking)
VI  - 200
IP  - 1
DP  - 2019 Jul 1
TI  - Short-Term Exposure to Ambient Air Pollution and Asthma Mortality.
PG  - 24-32
LID - 10.1164/rccm.201810-1823OC [doi]
AB  - Rationale: Short-term exposure to air pollution has been associated with asthma 
      exacerbation and increased healthcare use caused by asthma, but its effect on 
      asthma mortality remains largely unknown. Objectives: To quantitatively assess 
      the association between short-term exposure to air pollution and asthma 
      mortality. Methods: We investigated 4,454 individuals who lived in Hubei 
      province, China, and died from asthma between 2013 and 2018. A case-crossover 
      design and conditional logistic regression models were applied for data analyses. 
      Exposures to particulate matter </=2.5 mum in aerodynamic diameter (PM(2.5)), 
      particulate matter </=10 mum in aerodynamic diameter (PM(10)), sulfur dioxide 
      (SO(2)), nitrogen dioxide (NO(2)), carbon monoxide (CO), and ozone (O(3)) were 
      estimated by inverse distance weighted averages of all monitoring stations within 
      50 km from each case's home address. Measurements and Main Results: Each 
      interquartile range (IQR) increase of PM(2.5) (lag 3; IQR, 47.1 mug/m(3)), NO(2) 
      (lag 03; IQR, 26.3 mug/m(3)), and O(3) (lag 3; IQR, 52.9 mug/m(3)) were positively 
      associated with asthma mortality, with odds ratios of 1.07 (95% confidence 
      interval, 1.01-1.12), 1.11 (95% confidence interval, 1.01-1.22), and 1.09 (95% 
      confidence interval, 1.01-1.18), respectively. There was no evidence of departure 
      from linearity for these associations. Further adjustment for other pollutants 
      did not change the associations materially. We did not observe significant 
      associations between PM(10), SO(2), and CO exposures and asthma mortality. 
      Overall, the estimates remained consistent in various sensitivity analyses. 
      Conclusions: Our results provide new evidence that short-term exposures to 
      PM(2.5), NO(2), and O(3) may increase asthma mortality risk. Further studies are 
      needed to confirm our findings in other populations.
FAU - Liu, Yuewei
AU  - Liu Y
AUID- ORCID: 0000-0001-5970-4262
AD  - 1 Department of Epidemiology, School of Public Health, Sun Yat-sen University, 
      Guangzhou, China.
AD  - 2 Hubei Provincial Key Laboratory for Applied Toxicology and.
FAU - Pan, Jingju
AU  - Pan J
AUID- ORCID: 0000-0002-0099-7985
AD  - 3 Institute of Chronic Noncommunicable Disease Control and Prevention, Hubei 
      Provincial Center for Disease Control and Prevention, Wuhan, China.
FAU - Zhang, Hai
AU  - Zhang H
AD  - 2 Hubei Provincial Key Laboratory for Applied Toxicology and.
FAU - Shi, Chunxiang
AU  - Shi C
AD  - 4 National Meteorological Information Center, Beijing, China; and.
FAU - Li, Guo
AU  - Li G
AD  - 5 Department of Neurology, Tongji Hospital, and.
FAU - Peng, Zhe
AU  - Peng Z
AD  - 2 Hubei Provincial Key Laboratory for Applied Toxicology and.
FAU - Ma, Jixuan
AU  - Ma J
AD  - 6 Department of Occupational and Environmental Health, School of Public Health, 
      Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 
      China.
FAU - Zhou, Yun
AU  - Zhou Y
AUID- ORCID: 0000-0002-1758-7499
AD  - 6 Department of Occupational and Environmental Health, School of Public Health, 
      Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 
      China.
FAU - Zhang, Lan
AU  - Zhang L
AUID- ORCID: 0000-0001-7603-4045
AD  - 3 Institute of Chronic Noncommunicable Disease Control and Prevention, Hubei 
      Provincial Center for Disease Control and Prevention, Wuhan, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Respir Crit Care Med
JT  - American journal of respiratory and critical care medicine
JID - 9421642
RN  - 0 (Air Pollutants)
RN  - 0 (Particulate Matter)
RN  - 0UZA3422Q4 (Sulfur Dioxide)
RN  - 66H7ZZK23N (Ozone)
RN  - 7U1EE4V452 (Carbon Monoxide)
RN  - S7G510RUBH (Nitrogen Dioxide)
SB  - IM
CIN - Am J Respir Crit Care Med. 2019 Jul 1;200(1):1-2. PMID: 30912954
MH  - Aged
MH  - Aged, 80 and over
MH  - Air Pollutants
MH  - Air Pollution/*statistics & numerical data
MH  - Asthma/*mortality
MH  - Carbon Monoxide
MH  - China/epidemiology
MH  - Environmental Exposure/*statistics & numerical data
MH  - Environmental Monitoring
MH  - Female
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Nitrogen Dioxide
MH  - Odds Ratio
MH  - Ozone
MH  - *Particulate Matter
MH  - Sulfur Dioxide
OTO - NOTNLM
OT  - air pollutants
OT  - nitrogen dioxide
OT  - ozone
OT  - particulate matter
EDAT- 2019/03/16 06:00
MHDA- 2020/02/25 06:00
CRDT- 2019/03/16 06:00
PHST- 2019/03/16 06:00 [pubmed]
PHST- 2020/02/25 06:00 [medline]
PHST- 2019/03/16 06:00 [entrez]
AID - 10.1164/rccm.201810-1823OC [doi]
PST - ppublish
SO  - Am J Respir Crit Care Med. 2019 Jul 1;200(1):24-32. doi: 
      10.1164/rccm.201810-1823OC.