PMID- 30872258
OWN - NLM
STAT- MEDLINE
DCOM- 20190813
LR  - 20190813
IS  - 0253-9772 (Print)
IS  - 0253-9772 (Linking)
VI  - 41
IP  - 3
DP  - 2019 Mar 20
TI  - [Advances in mammalian three-dimensional genome by using Hi-C technology 
      approach].
PG  - 215-233
LID - 10.16288/j.yczz.18-317 [doi]
AB  - Mammalian genomic DNA in the cell nucleus doesn't exist in linear form but is 
      highly folded and condensed into chromatin with a three-dimensional (3D) 
      structure possessing a specific spatial structure and conformation. Hi-C, the 
      high-throughput chromosome conformation capture technology, was first published 
      in 2009, and it provides an in-depth view of 3D genomics. According to the size 
      of DNA unit, the 3D hierarchical units of mammalian genome can be categorized 
      sequentially as chromosome territory (CT), chromatin compartment A/B, topological 
      associated domain (TAD), and chromatin loop. These hierarchical structural units 
      play vital roles in gene transcription and regulation. In this review, we 
      summarize the 3D hierarchical division of chromosomes, the effects of 
      hierarchical units and the applications of Hi-C technology in development and 
      disease. This review is intended to provide insights for the further study of 3D 
      genomics in mammals.
FAU - Ning, Chun You
AU  - Ning CY
AD  - Institute of Animal Genetics and Breeding, College of Animal Science and 
      Technology, Sichuan Agricultural University, Chengdu 611130, China.
FAU - He, Meng Nan
AU  - He MN
AD  - Institute of Animal Genetics and Breeding, College of Animal Science and 
      Technology, Sichuan Agricultural University, Chengdu 611130, China.
FAU - Tang, Qian Zi
AU  - Tang QZ
AD  - Institute of Animal Genetics and Breeding, College of Animal Science and 
      Technology, Sichuan Agricultural University, Chengdu 611130, China.
FAU - Zhu, Qing
AU  - Zhu Q
AD  - Institute of Animal Genetics and Breeding, College of Animal Science and 
      Technology, Sichuan Agricultural University, Chengdu 611130, China.
FAU - Li, Ming Zhou
AU  - Li MZ
AD  - Institute of Animal Genetics and Breeding, College of Animal Science and 
      Technology, Sichuan Agricultural University, Chengdu 611130, China.
FAU - Li, Di Yan
AU  - Li DY
AD  - Institute of Animal Genetics and Breeding, College of Animal Science and 
      Technology, Sichuan Agricultural University, Chengdu 611130, China.
LA  - chi
PT  - Journal Article
PT  - Review
PL  - China
TA  - Yi Chuan
JT  - Yi chuan = Hereditas
JID - 9436478
RN  - 0 (Chromatin)
MH  - Animals
MH  - *Chromatin
MH  - *Chromosomes
MH  - *Genome
MH  - Genomics
MH  - Mammals/*genetics
MH  - Nucleic Acid Conformation
EDAT- 2019/03/16 06:00
MHDA- 2019/08/14 06:00
CRDT- 2019/03/16 06:00
PHST- 2019/03/16 06:00 [entrez]
PHST- 2019/03/16 06:00 [pubmed]
PHST- 2019/08/14 06:00 [medline]
AID - 10.16288/j.yczz.18-317 [doi]
PST - ppublish
SO  - Yi Chuan. 2019 Mar 20;41(3):215-233. doi: 10.16288/j.yczz.18-317.