PMID- 30875061
OWN - NLM
STAT- MEDLINE
DCOM- 20191226
LR  - 20191226
IS  - 1699-3055 (Electronic)
IS  - 1699-048X (Linking)
VI  - 21
IP  - 11
DP  - 2019 Nov
TI  - Skin and lung toxicity in synchronous bilateral breast cancer treated with 
      volumetric-modulated arc radiotherapy: a mono-institutional experience.
PG  - 1492-1498
LID - 10.1007/s12094-019-02077-z [doi]
AB  - PURPOSE: To evaluate acute and late skin/subcutaneous toxicities and 
      radiation-induced lung fibrosis (RILF) in patients treated with adjuvant 
      radiotherapy (RT) for synchronous bilateral breast cancers (SBBC), after 
      conservative surgery. METHODS/PATIENTS: Twenty-five patients were treated with 
      volumetric-modulated arc therapy (VMAT/RapidArc((R))) on both breasts, and checked 
      clinically for detecting RT toxicities during and after treatment. A 
      high-resolution computed tomography (HRCT) was performed, for detecting RILF 
      during follow-up. RESULTS: We registered acute Grade-1 skin toxicity in 18 
      patients (72%), while six patients (24%) experienced Grade-2 toxicity. No breath 
      symptoms were reported during and after RT. Late Grade-1 subcutaneous toxicity 
      and late Grade-2 skin toxicity were registered in four patients (16%) and one 
      patient (4%), respectively, at a mean follow-up of 36 months. Grade-1 RILF was 
      detected in six patients (30%). The median volume of fibrosis area was 6.5 cc 
      (range 1.3-21.5 cc). The partial volumes receiving a specified dose (V20, V30, 
      V40, and V50) in patients who developed lung fibrosis were significantly bigger 
      than who did not (p < 0.01). We showed that the mean volume of the tumour boost 
      of patients who developed fibrosis (77.7 cc) was not significantly different from 
      the other patients (90.8 cc) (p = 0.5). CONCLUSION: The clinical impact of this 
      technique is favourable, and this is the first clinical study showing RILF by 
      HRCT in a setting of SBBC. Further study with larger accrual is mandatory.
FAU - Valli, M
AU  - Valli M
AUID- ORCID: 0000-0002-7880-4645
AD  - Radiation Oncology Clinic, Oncology Institute of Southern Switzerland, 
      Bellinzona-Lugano, Via Ospedale, 6500, Bellinzona, Switzerland. 
      mariacarla.valli@eoc.ch.
FAU - Cima, S
AU  - Cima S
AD  - Radiation Oncology Clinic, Oncology Institute of Southern Switzerland, 
      Bellinzona-Lugano, Via Ospedale, 6500, Bellinzona, Switzerland.
FAU - Gaudino, D
AU  - Gaudino D
AD  - Medical Physics Service, Ente Ospedaliero Cantonale, Bellinzona, Switzerland.
FAU - Cartolari, R
AU  - Cartolari R
AD  - Radiology Service, Ente Ospedaliero Cantonale, Bellinzona, Switzerland.
FAU - Deantonio, L
AU  - Deantonio L
AD  - Radiation Oncology Clinic, Oncology Institute of Southern Switzerland, 
      Bellinzona-Lugano, Via Ospedale, 6500, Bellinzona, Switzerland.
FAU - Frapolli, M
AU  - Frapolli M
AD  - Radiation Oncology Clinic, Oncology Institute of Southern Switzerland, 
      Bellinzona-Lugano, Via Ospedale, 6500, Bellinzona, Switzerland.
FAU - Daniele, D
AU  - Daniele D
AD  - Radiation Oncology Clinic, Oncology Institute of Southern Switzerland, 
      Bellinzona-Lugano, Via Ospedale, 6500, Bellinzona, Switzerland.
FAU - Pesce, G A
AU  - Pesce GA
AD  - Radiation Oncology Clinic, Oncology Institute of Southern Switzerland, 
      Bellinzona-Lugano, Via Ospedale, 6500, Bellinzona, Switzerland.
FAU - Martucci, F
AU  - Martucci F
AD  - Radiation Oncology Clinic, Oncology Institute of Southern Switzerland, 
      Bellinzona-Lugano, Via Ospedale, 6500, Bellinzona, Switzerland.
FAU - Azinwi, N C
AU  - Azinwi NC
AD  - Radiation Oncology Clinic, Oncology Institute of Southern Switzerland, 
      Bellinzona-Lugano, Via Ospedale, 6500, Bellinzona, Switzerland.
FAU - Bosetti, D
AU  - Bosetti D
AD  - Radiation Oncology Clinic, Oncology Institute of Southern Switzerland, 
      Bellinzona-Lugano, Via Ospedale, 6500, Bellinzona, Switzerland.
FAU - Presilla, S
AU  - Presilla S
AD  - Medical Physics Service, Ente Ospedaliero Cantonale, Bellinzona, Switzerland.
FAU - Richetti, A
AU  - Richetti A
AD  - Radiation Oncology Clinic, Oncology Institute of Southern Switzerland, 
      Bellinzona-Lugano, Via Ospedale, 6500, Bellinzona, Switzerland.
LA  - eng
PT  - Journal Article
DEP - 20190314
PL  - Italy
TA  - Clin Transl Oncol
JT  - Clinical & translational oncology : official publication of the Federation of 
      Spanish Oncology Societies and of the National Cancer Institute of Mexico
JID - 101247119
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Breast Neoplasms/diagnostic imaging/*radiotherapy
MH  - Feasibility Studies
MH  - Female
MH  - Humans
MH  - Lung/diagnostic imaging/*radiation effects
MH  - Middle Aged
MH  - Neoplasms, Multiple Primary/diagnostic imaging/*radiotherapy
MH  - Organs at Risk/diagnostic imaging/radiation effects
MH  - Radiation Pneumonitis/diagnostic imaging/*etiology
MH  - Radiotherapy Planning, Computer-Assisted/methods
MH  - Radiotherapy, Adjuvant/adverse effects
MH  - Radiotherapy, Intensity-Modulated/*adverse effects
MH  - Retrospective Studies
MH  - Skin/*radiation effects
MH  - Tomography, X-Ray Computed/methods
OTO - NOTNLM
OT  - Radiation-induced lung fibrosis
OT  - Synchronous bilateral breast cancer
OT  - Volumetric-modulated arc therapy
EDAT- 2019/03/16 06:00
MHDA- 2019/12/27 06:00
CRDT- 2019/03/16 06:00
PHST- 2018/12/04 00:00 [received]
PHST- 2019/02/27 00:00 [accepted]
PHST- 2019/03/16 06:00 [pubmed]
PHST- 2019/12/27 06:00 [medline]
PHST- 2019/03/16 06:00 [entrez]
AID - 10.1007/s12094-019-02077-z [pii]
AID - 10.1007/s12094-019-02077-z [doi]
PST - ppublish
SO  - Clin Transl Oncol. 2019 Nov;21(11):1492-1498. doi: 10.1007/s12094-019-02077-z. 
      Epub 2019 Mar 14.