PMID- 30875143
OWN - NLM
STAT- MEDLINE
DCOM- 20190802
LR  - 20190802
IS  - 1399-3062 (Electronic)
IS  - 1398-2273 (Linking)
VI  - 21
IP  - 3
DP  - 2019 Jun
TI  - Low incidence of HHV-6 reactivation in haploidentical hematopoietic stem cell 
      transplantation with corticosteroid as graft-vs-host disease prophylaxis compared 
      with cord blood transplantation.
PG  - e13073
LID - 10.1111/tid.13073 [doi]
AB  - BACKGROUND: Human leukocyte antigen (HLA) mismatch and the administration of 
      immunosuppressive agents are considered risks for human herpesvirus 6 (HHV-6) 
      reactivation after stem cell transplantation (SCT). However, the incidence of 
      HHV-6 reactivation in HLA-mismatched related SCT remains unknown. METHODS: We 
      monitored plasma HHV-6 DNA loads weekly using real-time quantitative polymerase 
      chain reaction for 5 weeks after SCT and compared serum IL-6 levels in 
      HLA-mismatched SCT groups. RESULTS: Compared with detection in all 11 umbilical 
      cord blood transplantation (CBT) patients (100%), plasma HHV-6 DNA was detected 
      in only 3 of 42 haplo-SCT patients (7.1%) despite the use of methylprednisolone 
      and antithymocyte globulin as graft-vs-host disease prophylaxis and a 
      reduced-intensity conditioning regimen, respectively. Correspondingly, serum IL-6 
      levels in haplo-SCT patients were significantly lower than those in CBT patients. 
      No HHV-6-associated encephalitis developed in either groups. CONCLUSIONS: Neither 
      HLA disparity nor the use of methylprednisolone and antithymocyte globulin were 
      risk factors for HHV-6 reactivation in our haplo-SCT patients. Rather than 
      increasing risk, the administration of immunosuppressive agents potentially 
      prevented HHV-6 reactivation after haplo-SCT by suppressing IL-6 production.
CI  - (c) 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Tamaki, Hiroya
AU  - Tamaki H
AUID- ORCID: 0000-0003-3348-7110
AD  - Division of Hematology, Department of Internal Medicine, Hyogo College of 
      Medicine, Nishinomiya, Japan.
FAU - Ikegame, Kazuhiro
AU  - Ikegame K
AD  - Division of Hematology, Department of Internal Medicine, Hyogo College of 
      Medicine, Nishinomiya, Japan.
FAU - Yoshihara, Satoshi
AU  - Yoshihara S
AD  - Division of Hematology, Department of Internal Medicine, Hyogo College of 
      Medicine, Nishinomiya, Japan.
FAU - Kaida, Katsuji
AU  - Kaida K
AD  - Division of Hematology, Department of Internal Medicine, Hyogo College of 
      Medicine, Nishinomiya, Japan.
FAU - Yoshihara, Kyoko
AU  - Yoshihara K
AD  - Division of Hematology, Department of Internal Medicine, Hyogo College of 
      Medicine, Nishinomiya, Japan.
FAU - Inoue, Takayuki
AU  - Inoue T
AD  - Division of Hematology, Department of Internal Medicine, Hyogo College of 
      Medicine, Nishinomiya, Japan.
FAU - Kato, Ruri
AU  - Kato R
AD  - Division of Hematology, Department of Internal Medicine, Hyogo College of 
      Medicine, Nishinomiya, Japan.
FAU - Nakata, Jun
AU  - Nakata J
AD  - Division of Hematology, Department of Internal Medicine, Hyogo College of 
      Medicine, Nishinomiya, Japan.
FAU - Fujioka, Tatsuya
AU  - Fujioka T
AD  - Division of Hematology, Department of Internal Medicine, Hyogo College of 
      Medicine, Nishinomiya, Japan.
FAU - Soma, Toshihiro
AU  - Soma T
AD  - Division of Hematology, Department of Internal Medicine, Hyogo College of 
      Medicine, Nishinomiya, Japan.
AD  - Laboratory of Cell Transplantation, Institute for Advanced Medical Sciences, 
      Hyogo College of Medicine, Nishinomiya, Japan.
FAU - Okada, Masaya
AU  - Okada M
AD  - Division of Hematology, Department of Internal Medicine, Hyogo College of 
      Medicine, Nishinomiya, Japan.
FAU - Ogawa, Hiroyasu
AU  - Ogawa H
AD  - Division of Hematology, Department of Internal Medicine, Hyogo College of 
      Medicine, Nishinomiya, Japan.
AD  - Laboratory of Cell Transplantation, Institute for Advanced Medical Sciences, 
      Hyogo College of Medicine, Nishinomiya, Japan.
LA  - eng
GR  - 2017/Hyogo College of Medicine/
PT  - Comparative Study
PT  - Journal Article
DEP - 20190401
PL  - Denmark
TA  - Transpl Infect Dis
JT  - Transplant infectious disease : an official journal of the Transplantation 
      Society
JID - 100883688
RN  - 0 (Adrenal Cortex Hormones)
RN  - 0 (Antilymphocyte Serum)
RN  - 0 (DNA, Viral)
RN  - 0 (HLA Antigens)
RN  - 0 (IL6 protein, human)
RN  - 0 (Immunosuppressive Agents)
RN  - 0 (Interleukin-6)
RN  - X4W7ZR7023 (Methylprednisolone)
MH  - Adolescent
MH  - Adrenal Cortex Hormones/*therapeutic use
MH  - Adult
MH  - Aged
MH  - Antilymphocyte Serum/therapeutic use
MH  - Cord Blood Stem Cell Transplantation/*adverse effects
MH  - DNA, Viral/blood
MH  - Female
MH  - Graft vs Host Disease/*prevention & control
MH  - HLA Antigens/genetics
MH  - Hematopoietic Stem Cell Transplantation/*adverse effects
MH  - Herpesvirus 6, Human/physiology
MH  - Histocompatibility
MH  - Humans
MH  - Immunosuppressive Agents/*therapeutic use
MH  - Incidence
MH  - Interleukin-6/blood
MH  - Male
MH  - Methylprednisolone/therapeutic use
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Roseolovirus Infections/*diagnosis
MH  - Transplantation Conditioning
MH  - Virus Activation/*drug effects
MH  - Young Adult
OTO - NOTNLM
OT  - HHV-6 reactivation
OT  - HLA-mismatched/haploidentical transplantation
OT  - cord blood transplantation
OT  - encephalitis
OT  - interleukin-6
EDAT- 2019/03/16 06:00
MHDA- 2019/08/03 06:00
CRDT- 2019/03/16 06:00
PHST- 2018/10/19 00:00 [received]
PHST- 2019/01/31 00:00 [revised]
PHST- 2019/02/24 00:00 [accepted]
PHST- 2019/03/16 06:00 [pubmed]
PHST- 2019/08/03 06:00 [medline]
PHST- 2019/03/16 06:00 [entrez]
AID - 10.1111/tid.13073 [doi]
PST - ppublish
SO  - Transpl Infect Dis. 2019 Jun;21(3):e13073. doi: 10.1111/tid.13073. Epub 2019 Apr 
      1.