PMID- 30875606
OWN - NLM
STAT- MEDLINE
DCOM- 20200706
LR  - 20200706
IS  - 1879-0372 (Electronic)
IS  - 0952-7915 (Linking)
VI  - 58
DP  - 2019 Jun
TI  - Dendritic cells are what they eat: how their metabolism shapes T helper cell 
      polarization.
PG  - 16-23
LID - S0952-7915(18)30108-0 [pii]
LID - 10.1016/j.coi.2019.02.003 [doi]
AB  - Dendritic cells (DCs) are professional antigen-presenting cells that play a 
      crucial role in the priming and differentiation of CD4(+) T cells into several 
      distinct subsets including effector T helper (Th) 1, Th17 and Th2 cells, as well 
      as regulatory T cells (Tregs). It is becoming increasingly clear that cellular 
      metabolism shapes the functional properties of DCs. Specifically, the ability of 
      DCs to drive polarization of different Th cell subsets may be orchestrated by the 
      engagement of distinct metabolic pathways. In this review, we will discuss the 
      recent advances in the DC metabolism field, by focusing on how cellular 
      metabolism of DCs shapes their priming and polarization of distinct Th cell 
      responses.
CI  - Copyright (c) 2019 Elsevier Ltd. All rights reserved.
FAU - Patente, Thiago A
AU  - Patente TA
AD  - Department of Parasitology, Leiden University Medical Center, Leiden, The 
      Netherlands; Laboratory of Tumor Immunology, Department of Immunology, Institute 
      of Biomedical Sciences, University of Sao Paulo, SP, Brazil.
FAU - Pelgrom, Leonard R
AU  - Pelgrom LR
AD  - Department of Parasitology, Leiden University Medical Center, Leiden, The 
      Netherlands.
FAU - Everts, Bart
AU  - Everts B
AD  - Department of Parasitology, Leiden University Medical Center, Leiden, The 
      Netherlands. Electronic address: b.everts@lumc.nl.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20190312
PL  - England
TA  - Curr Opin Immunol
JT  - Current opinion in immunology
JID - 8900118
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Animals
MH  - Antigen Presentation/immunology
MH  - CD4-Positive T-Lymphocytes/*immunology/metabolism
MH  - Cell Differentiation/*immunology
MH  - Dendritic Cells/*immunology/metabolism
MH  - Histocompatibility Antigens Class II/immunology
MH  - Humans
MH  - Lymphocyte Activation/*immunology
MH  - T-Lymphocytes, Helper-Inducer/*immunology/metabolism
MH  - T-Lymphocytes, Regulatory/*immunology/metabolism
EDAT- 2019/03/16 06:00
MHDA- 2020/07/07 06:00
CRDT- 2019/03/16 06:00
PHST- 2018/11/25 00:00 [received]
PHST- 2019/02/05 00:00 [revised]
PHST- 2019/02/14 00:00 [accepted]
PHST- 2019/03/16 06:00 [pubmed]
PHST- 2020/07/07 06:00 [medline]
PHST- 2019/03/16 06:00 [entrez]
AID - S0952-7915(18)30108-0 [pii]
AID - 10.1016/j.coi.2019.02.003 [doi]
PST - ppublish
SO  - Curr Opin Immunol. 2019 Jun;58:16-23. doi: 10.1016/j.coi.2019.02.003. Epub 2019 
      Mar 12.